I'd go along with what Ronald said, especially the bit about your publisher/printer's tastes (if you're lucky, you'll find one that accepts a straightforward TeX document, but this is a rarity outside academic publishing). I still think Knuth's Computer Modern fonts provide the most elegant solution, though, since the different faces are designed to go well together. OTOH, if your printer asks for copy in PDF format (as apparently most do these days) you may have problems using non-Adobe fonts.
BTW, I heard on another list that printers aren't keen on the PDF output from ps2pdf. Anybody know what the problem is? Robin