For what it's worth, I've maintained a local area network of 20-or-so  
Macs for about 15 years now (with remarkably few problems, I might  
add), and I have only used an anti-virus program for a brief time in  
the late 1990s, when some of our computers got infected with a Word  
macro virus (non-destructive). I ran the Sophos anti-virus program on  
all computers until we got rid of that.

Since moving to OS X several years ago we have not installed any anti- 
virus programs nor encountered any viruses. And I'm sure the users are  
surfing all manner of web sites and downloading all manner of files.  
If harmful Mac viruses start appearing, we will start using anti-virus  
programs; until then, I don't see any point in doing so.

I have not defragged any Mac hard drives since moving to OS X, and  
have not found any reason to do so.

Dan




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