It sounds like your mail file.

Mac Mail uses one file per message.
Old unix mbox format is one file with all of your messages.

This sounds like outlook/citrix is using unix mail format, rather than one 
message per file format.

On 2017-04-18, at 8:00 AM, Dinse, Gregg (NIH/NIEHS) [C] <di...@niehs.nih.gov> 
wrote:

> Hi,
> 
> I have been using Time Machine for many years, but lately the backups seem to 
> be much larger than usual (i.e., hundreds of MB rather than just a few MB), 
> even when I have not done anything.
> 
> This problem is on my Mac at work, where the only things that have changed 
> lately (that I recall) are:
> 
> 1. We were forced to switch to Outlook (I had always used Apple Mail before).
> 
> 2. Citrix was installed, so that I could access my work email in Outlook from 
> home.
> 
> Is there some large file (e.g., a database) associated with Outlook that 
> keeps getting updated and thus backed up again and again?  If so, what is it 
> called and where is it located?  This reminds me of the time when I used 
> Parallels, which kept the virtual Windows machine in a large file and every 
> time something changed in Windows, even something small, the entire large 
> Parallels file would get backed up again in Time Machine.  Eventually I 
> excluded that file from my backups.
> 
> Currently I only backup part of my main system drive.  I exclude 
> /Applications, /Library, and System Files and Applications.  Essentially I 
> just backup my user files.
> 
> Does anyone have any thoughts about what might be causing my Time Machine 
> backups to be so much larger lately?  It seems like it might be related to me 
> being forced to start using Outlook, since the timing is right.
> 
> Thanks,
> 
> Gregg
> 
> 
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