Thank you, Those are the studies I read and took notice of. Seems to be a promising line of investigation to the problem.
On Tue, Mar 13, 2018 at 1:18 AM, archer75--- via Mercedes < mercedes@okiebenz.com> wrote: > As G Mann wrote: The involvement of the brain is now a major interest of > those researching the cause and treatment of tinnitus. Following is one > interesting approach. Research on the cause(s) of tinnitus are interesting, > but since Andrew is probably most interested in treatment and relief, he > might be better off going to a clinic that specializes in treatment and > relief. Then, if that clinic affords no relief, he still has the option of > going to a clinic doing research on tinnitus. Of course, that is just a > guess since there is no way of knowing which clinic in the DC area would > help Andrew the most. > Gerry > > Neuroscientists Identify Brain Mechanism Responsible for Tinnitus, Chronic > Pain > > Neuroscientists at Georgetown University Medical Center (GUMC) and > Germany’s Technische Universität München report that they’ve identified the > brain mechanism responsible for tinnitus and chronic pain — the symptoms > that can persist long after an initial injury. > > In an article slated to appear in the October 2015 issue of Trends in > Cognitive Sciences, researchers explain that identifying the underlying > problem is the first step to developing effective therapies for tinnitus > and chronic pain. In their article, the scientists describe how the neural > mechanisms that normally “gate” or control noise and pain signals can > become dysfunctional, leading to a chronic perception of these sensations. > In their study, the researchers traced the flow of these signals through > the brain and showed where “circuit breakers” should be working, but aren’t. > > In both disorders, according to the research team, the brain has been > reorganized in response to an injury in its sensory apparatus. Tinnitus can > occur after the ears are damaged by loud noise or other issue, but even > after the brain reorganizes itself, it continues to “hear” a constant hum > or drum. Chronic pain can occur from an injury that often is healed > elsewhere in the body but persists inside the brain. > > Josef Rauschecker, PhD, DSc, Georgetown University Medical Center wrote: > > “Some people call these phantom sensations, but they are real, produced by > a brain that continues to ‘feel’ the initial injury because it cannot > down-regulate the sensations enough,” said Josef Rauschecker, PhD, DSc, > director of the Laboratory for Integrative Neuroscience and Cognition at > GUMC. “Both conditions are extraordinarily common, yet no treatment gets to > the root of these disorders.” > > The researchers report that areas of the brain responsible for these > errant sensations are the nucleus accumbens, the reward and learning > center, as well as other brain regions that serve “executive” or > administrative roles, such as the ventromedial prefrontal cortex (VNPFC), > and the anterior cingulate cortex. All of these areas are also important > for evaluating and modulating emotional experiences, according to > Rauschecker. > > “These areas act as a central gatekeeping system for perceptual > sensations, which evaluate the affective meaning of sensory stimuli — > whether produced externally or internally — and modulate information flow > in the brain. Tinnitus and chronic pain occur when this system is > compromised,” Rauschecker says. He notes that other issues often arise in > concert with tinnitus and/or chronic pain, such as depression and anxiety, > which are also modulated by the nucleus accumbens. Uncontrollable or > long-term stress is another important factor in these symptoms. > > The brain plasticity that produces some of these changes provides hope > that this gatekeeping role can be restored. Because these systems rely on > transmission of dopamine and serotonin between neurons, drugs that modulate > dopamine may help restore sensory gating. > > > Markus Ploner, MD, PhD, TUM School of Medicine > “Better understanding could also lead to standardized assessment of > individuals’ risk to develop chronic tinnitus and chronic pain, which in > turn might allow for earlier and more targeted treatment,” said Markus > Ploner, MD, PhD, a consultant neurologist and Heisenberg Professor of Human > Pain Research at the Technische Universität München (TUM) in Germany. > > Rauschecker, an expert in tinnitus, collaborated with Ploner, who studies > chronic pain, during his senior fellowship at the Institute of Advanced > Study at TUM. Co-authors include Audrey Maudoux, MD, PhD, from GUMC and > Elisabeth May, PhD, from TUM. > > Source: Newswise; Trends in Cognitive Sciences; Georgetown University > Medical Center > > For a related story, read this article describing a research study from > McGill University Medical Centre that looks at the neuropathic pathways of > pain–or, “pain in the brain.” > ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ > G Mann wrote: > > The latest research I've come across identifies the source of Tinnitus to > > be located in the brain, rather than in the ear. The sounds you are > hearing > > are "electrical discharge" located in the brain cells, according to the > > latest investigations. > > > > I didn't do the research... just read the results... your mileage may > vary. > > > > On Mon, Mar 12, 2018 at 11:58 AM, Andrew Strasfogel via Mercedes < > > mercedes@okiebenz.com> wrote: > > > > > Thanks for the awesome feedback. What a learned group! I will > definitely > > > check out the clinic at the U of M. > > > > > > The only logical explanation I can come up with is that the blood > rushing > > > past some misaligned cilia (hairs) deep In the inner air are making the > > > hissing sound. This might account for its constancy. > > > > > > On Mon, Mar 12, 2018 at 12:09 PM, Floyd Thursby via Mercedes < > > > mercedes@okiebenz.com> wrote: > > > > > > > That would be the tuning aspect, somehow to generate an out-of-phase > > > > signal. More research needed! > > > > > > > > --FT > > > > > > > > > > > > > > > > On 3/12/18 11:55 AM, Greg Fiorentino via Mercedes wrote: > > > > > > > >> I can't think of a way the headphones could sample the "noise", much > > > less > > > >> generate an out-of-phase countering signal. > > > >> > > > >> Greg > > > >> > > > >> -----Original Message----- > > > >> From: Mercedes [mailto:mercedes-boun...@okiebenz.com] On Behalf Of > > > Floyd > > > >> Thursby via Mercedes > > > >> Sent: Monday, March 12, 2018 7:41 AM > > > >> To: mercedes@okiebenz.com > > > >> Cc: Floyd Thursby > > > >> Subject: Re: [MBZ] Way OT: Tinnitus > > > >> > > > >> I wonder if something similar to noise-canceling headphones could > work > > > to > > > >> generate anti-tinnitus sounds. One would have to tune them to > > > individual > > > >> circumstances but the question is if the noise would cancel out > whatever > > > >> the nerves or brain are doing, or if it would just add to the > overall > > > >> sensation of more noise. > > > >> > > > >> --FT > > > >> > > > >> > > > >> On 3/12/18 5:30 AM, Dan Penoff via Mercedes wrote: > > > >> > > > >>> Had it for some time, no doubt due to loud music and working around > > > >>> industrial engines. Pitch can change as can the intensity. It’s a > > > >>> nuisance, but not debilitating, fortunately. > > > >>> > > > >>> One of my former business partners had it so bad that it could lay > him > > > >>> out. I consider myself lucky. > > > >>> > > > >>> -D > > > >>> > > > >>> > > > >>> On Mar 12, 2018, at 3:05 AM, Rick Knoble via Mercedes < > > > >>>> mercedes@okiebenz.com> wrote: > > > >>>> > > > >>>> Andrew says: > > > >>>> > > > >>>> I recently noticed a persistent background >hissing noise that is > > > >>>>> not ambient but exists >inside my head > > > >>>>> > > > >>>> Mine is the same frequency as the 18khz oscillator in old CRT > > > >>>> televisions. Actually, it's a tritone, all around the same > frequency. > > > >>>> Sounds like a cricket chirp, except continuous. I've had it for > many > > > >>>> decades. > > > >>>> > > > >>>> It never goes away. Ever. > > > >>>> > > > >>>> At least you're not hearing voices in your head... > > > >>>> > > > >>>> Rick > > > >>>> > > > >>>> _______________________________________ > > > >>>> http://www.okiebenz.com > > > >>>> > > > >>>> To search list archives http://www.okiebenz.com/archive/ > > > >>>> > > > >>>> To Unsubscribe or change delivery options go to: > > > >>>> http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > > >>>> > > > >>>> > > > >>>> _______________________________________ > > > >>> http://www.okiebenz.com > > > >>> > > > >>> To search list archives http://www.okiebenz.com/archive/ > > > >>> > > > >>> To Unsubscribe or change delivery options go to: > > > >>> http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > > >>> > > > >>> -- > > > >> --FT > > > >> > > > >> > > > >> _______________________________________ > > > >> http://www.okiebenz.com > > > >> > > > >> To search list archives http://www.okiebenz.com/archive/ > > > >> > > > >> To Unsubscribe or change delivery options go to: > > > >> http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > > >> > > > >> > > > >> > > > >> _______________________________________ > > > >> http://www.okiebenz.com > > > >> > > > >> To search list archives http://www.okiebenz.com/archive/ > > > >> > > > >> To Unsubscribe or change delivery options go to: > > > >> http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > > >> > > > >> > > > > -- > > > > --FT > > > > > > > > > > > > _______________________________________ > > > > http://www.okiebenz.com > > > > > > > > To search list archives http://www.okiebenz.com/archive/ > > > > > > > > To Unsubscribe or change delivery options go to: > > > > http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > > > > > > > > > > _______________________________________ > > > http://www.okiebenz.com > > > > > > To search list archives http://www.okiebenz.com/archive/ > > > > > > To Unsubscribe or change delivery options go to: > > > http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > > > > > > > _______________________________________ > > http://www.okiebenz.com > > > > To search list archives http://www.okiebenz.com/archive/ > > > > To Unsubscribe or change delivery options go to: > > http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > > > > -- > arche...@embarqmail.com <arche...@embarqmail.com> > > --- > This email has been checked for viruses by AVG. > http://www.avg.com > > > _______________________________________ > http://www.okiebenz.com > > To search list archives http://www.okiebenz.com/archive/ > > To Unsubscribe or change delivery options go to: > http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > > _______________________________________ http://www.okiebenz.com To search list archives http://www.okiebenz.com/archive/ To Unsubscribe or change delivery options go to: http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com
