This is informative. Thank you! -D
> On Sep 15, 2020, at 10:04 AM, Buggered Benzmail via Mercedes > <mercedes@okiebenz.com> wrote: > > Vaccine trials going on now. 3 friends (One immunologist prof who developed > her own antibody tests and is on the biosafety committee at the hospital, > another who is MD/PhD on boards of various drug companies and affiliated with > drug development efforts at the hospital, and his wife) got the first Astra > Zeneca doses (maybe, 2/3 chance in this trial, others are 50/50) 2 weeks ago > locally. Trials were briefly suspended last week after a possibly (but not > likely)-related illness in U.K. But will likely resume maybe this week after > NIH give the go-ahead. A/Z are doing trials in U.K. US and Brazil. > > I had some beers with my MD/PhD buddy last night and we discussed this in > some detail. They get a second dose likely next week, and blood draws to > monitor responses. > > There are 2 other trials going on locally too for other vaccines. (The > different vaccines address different biological aspects of the virus, I > forget the specific chemistry he told me but it has to do with the structure > and function of the virus, which is actually pretty nasty and unique, hence > the vaccine challenges and possibly different effectivenesses). > > He says one vaccine would likely give 50-70% immunity, you can take 2 or 3 > different types and that would boost your likely immunity up pretty high (flu > shots are like 70% effective for a comparison) and would last maybe a coupla > years as your biology kinda winds down after awhile and forgets about it. > > My immunologist friend is tempted to run her own antibody test on herself to > see if she got the dose or placebo. Or maybe a friend might do it... > > I signed up for the A/Z trial with the higher (2/3) dose probability and am > waiting to hear in the next coupla weeks after the initial tranche (60 > people) are observed and the trial resumes. They had 3000 people sign up , he > thinks I have a pretty good chance (nudge nudge wink wink) of getting invited > in. If you get the actual dose, and it actually works, your immunity would > develop over a month or two, it is not necessarily immediate, which is how > these things work. And even if tests don’t show you have the antibodies, you > might still have immunity because humans have different mechanisms (I think > he told me there are 3 mechanisms) for immunity not all of which will show up > on the easier tests. So a lot of it is biology and not really “testable” for > immediate results. > > He figures there should be some strong clinical results over the next 3-4 > months and vaccines should start becoming available in 4-6 months if all goes > well. And again you could take 2 or 3 different vaccines if available. Yes > it takes time but this is actually pretty accelerated given the biology of it > all. > > So that is probably as much as anyone knows (dumbed down a bit for my > consumption) coming from someone right in the middle of it all. I think I > got most of it right, there was beer involved... It was all quite > informative and encouraging, but practically drug development takes time and > this is being accelerated but still trying to maintain safety. > > --FT > Sent from iPhone > >> On Sep 15, 2020, at 7:59 AM, Curt Raymond via Mercedes >> <mercedes@okiebenz.com> wrote: >> >> What do you give the odds of a vaccine in the next year or so? I know a >> lot of folks are busting hump to get one but it seems unlikely to me >> considering the fastest vaccine ever took 4 years... >> -Curt >> >> On Tuesday, September 15, 2020, 12:49:57 AM EDT, archer75--- via Mercedes >> <mercedes@okiebenz.com> wrote: >> >>> On Sun, 13 Sep 2020 16:08:21 +0000 >>> Rick Knoble via Mercedes <mercedes@okiebenz.com> wrote: >>> >>> Long time, no hear... >> >>> Rick >>> _______________________________________ >> >> Hi Rick, >> I'm still here; enjoying all the activity on Okiebenz. >> Looking forward to an effective vaccine. >> Thanks for your concern. >> Gerry >> >> -- >> This email has been checked for viruses by AVG. >> https://www.avg.com >> >> >> _______________________________________ >> http://www.okiebenz.com >> >> To search list archives http://www.okiebenz.com/archive/ >> >> To Unsubscribe or change delivery options go to: >> http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com >> >> >> _______________________________________ >> http://www.okiebenz.com >> >> To search list archives http://www.okiebenz.com/archive/ >> >> To Unsubscribe or change delivery options go to: >> http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com >> > > _______________________________________ > http://www.okiebenz.com > > To search list archives http://www.okiebenz.com/archive/ > > To Unsubscribe or change delivery options go to: > http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com > _______________________________________ http://www.okiebenz.com To search list archives http://www.okiebenz.com/archive/ To Unsubscribe or change delivery options go to: http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com
