Hi,
Let me explain what my observations are and I hope that with your help I'll go further to resolve my issue.
From time to time I got many errors in messages:

[ns]~$ tail /var/log/messages
Feb 28 23:23:27 ns /bsd: com1: 25 silo overflows, 0 ibuf overflows
Feb 28 23:24:34 ns /bsd: com1: 28 silo overflows, 0 ibuf overflows
Feb 28 23:25:42 ns /bsd: com1: 30 silo overflows, 0 ibuf overflows
Feb 28 23:26:50 ns /bsd: com1: 23 silo overflows, 0 ibuf overflows
Feb 28 23:27:57 ns /bsd: com1: 23 silo overflows, 0 ibuf overflows
Feb 28 23:29:09 ns /bsd: com1: 20 silo overflows, 0 ibuf overflows
Feb 28 23:30:16 ns /bsd: com1: 12 silo overflows, 0 ibuf overflows
Feb 28 23:31:23 ns /bsd: com1: 12 silo overflows, 0 ibuf overflows
Feb 28 23:32:28 ns /bsd: com1: 10 silo overflows, 0 ibuf overflows
Feb 28 23:33:34 ns /bsd: com1: 16 silo overflows, 0 ibuf overflows

I have NMEA sensor (Garmin GPS 18x Lvc) which is used for time source for OpenNTPD

/etc/ttys:
...
tty01   "/sbin/ldattach -t dcd nmea"    unknown on  mdmbuf
...

[ns]~$ cat /etc/ntpd.conf
# Addresses to listen on (ntpd does not listen by default)
listen on *

servers 1.bg.pool.ntp.org
servers 2.bg.pool.ntp.org
servers 3.europe.pool.ntp.org

# use a specific local timedelta sensor (radio clock, etc)
sensor nmea0 correction 600 weight 10 refid GPS

# get the time constraint from a well-known HTTPS site
constraints from "https://www.google.com/search?q=openntpd";

From man com:
com0: N silo overflows The input ``silo'' has overflowed and incoming
             data has been lost.
As I understand the buffer of UART (16 byte) has been overflowed because UART can't interrupt the CPU, or I'm wrong.

You may see that some GPRMC sentences weren't whole because of data loss:
[ns]~$ sudo cu -l /dev/cua01 -s 4800
Connected to /dev/cua01 (speed 4800)
$GPRMC,215204,A,4241.2899,N,02319.6677,E,000.0,079.5,280215,004.5,E*70
$GPRMC,215205,A,4241.2899,N,02319.6676,E,000.0,079.5,280*70
$GPRMC,215206,A,4241.2898,N,02319.6680,E,000.0,05,004.5,E*7B
$GPRMC,215207,A,4241.2895,N,02319.6671,E,000.0,079.5,280215,004.5,E*79
$GPRMC,215208,A,4241.2894,N,02319.6670,E,000.0,079.5,280215,004.5,E*76
$GPRMC,215209,A,4241.2894,N,02319.6670,E,000.0,079.5,280215,004.5,E*77
$GPRMC,215210,A,4241.2895,N,02319.6670,E,000.0,079.5,280215,004.5,E*7E
$GPRMC,215211,A,4241.2896,N,02319.6670,E9.5,280215,004.5,E*7C
$GPRMC,215212,A,4241.2897,N,02319.6670,E,000.0,079.5,280215,004.5,E*7E
$GPRMC,215213,A,4241.2897,N,02319.6670,E,000.0,05,004.5,E*7F
$GPRMC,215214,A,4241.2897,N,02319.6669,E,000.0,079.5,280215,004.5,E*70
$GPRMC,215215,A,41.2898,N,02319.6669,E,000.0,079.5,280215,004.5,E*7E
$GPRMC,215216,A,4241.2909,N,02319.6669,E,001.3,348.7,280215,004.5,E*75
$GPRMC,215217,A,4241.2920,N,02319.6673,E,001.3,354.6,2808
$GPRMC,215218,A,4241.2932,N,02319.6676,E80215,004.5,E*73
$GPRMC,215219,A,241.2943,N,02319.6680,E,001.8,356.6,280215,004.5,E*76
$GPRMC,215220,A,4241.2954,N,02319.6683,E,002.0,359.7,280215,004.5,E*7C
$GPRMC,215221,A,4241.2964,N,02319.6684,E,002.0,356.6,280*77
$GPRMC,215222,A,4241.2977,N,02319.6689,E,002.1,358.2,280215,004.5,E*70
$GPRMC,215223,A,4241.2981,N,02319.6700,E,001.6,009.3,280215,004.5,E*7A

I also observed that kern.netlivelocks are increasing with one or two every two/three seconds.
[ns]~$ sysctl -a | grep livelock
kern.netlivelocks=2720

Here my knowledge ends but I can provide more details if you tell me how.

[ns]~$ uptime
11:28PM  up 8 days,  1:28, 1 user, load averages: 0.36, 0.35, 0.33

[ns]~$ vmstat -i
interrupt                       total     rate
irq0/clock                  276233041      396
irq0/ipi                     40525429       58
irq101/uhci0                 69369194       99
irq104/ehci0                        2        0
irq112/em0                  378518877      543
irq113/em1                  319490873      458
irq108/ahci0                 10221709       14
irq104/ichiic0                4545480        6
irq145/com0                       154        0
irq146/com1                   7527171       10
Total                      1106431930     1588

dmesg:

OpenBSD 5.7-beta (GENERIC.MP) #858: Fri Feb 20 06:47:16 MST 2015
    t...@amd64.openbsd.org:/usr/src/sys/arch/amd64/compile/GENERIC.MP
real mem = 6416760832 (6119MB)
avail mem = 6242033664 (5952MB)
mpath0 at root
scsibus0 at mpath0: 256 targets
mainbus0 at root
bios0 at mainbus0: SMBIOS rev. 2.6 @ 0x9ac00 (37 entries)
bios0: vendor American Megatrends Inc. version "2.0b" date 11/07/2013
bios0: Supermicro X8ST3
acpi0 at bios0: rev 2
acpi0: sleep states S0 S1 S4 S5
acpi0: tables DSDT FACP APIC MCFG OEMB HPET DMAR SSDT EINJ BERT ERST HEST acpi0: wakeup devices P0P1(S4) PS2K(S4) PS2M(S4) USB0(S4) USB1(S4) USB2(S4) USB5(S4) EUSB(S4) USB3(S4) USB4(S4) USB6(S4) USBE(S4) GBE_(S4) P0P4(S4) P0P5(S4) P0P6(S4) [...]
acpitimer0 at acpi0: 3579545 Hz, 24 bits
acpimadt0 at acpi0 addr 0xfee00000: PC-AT compat
cpu0 at mainbus0: apid 0 (boot processor)
cpu0: Intel(R) Core(TM) i7 CPU 950 @ 3.07GHz, 3067.11 MHz
cpu0: FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DTES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,SSE4.1,SSE4.2,POPCNT,NXE,LONG,LAHF,PERF,ITSC
cpu0: 256KB 64b/line 8-way L2 cache
cpu0: smt 0, core 0, package 0
mtrr: Pentium Pro MTRR support, 8 var ranges, 88 fixed ranges
cpu0: apic clock running at 133MHz
cpu0: mwait min=64, max=64, C-substates=0.2.1.1.0, IBE
cpu1 at mainbus0: apid 2 (application processor)
cpu1: Intel(R) Core(TM) i7 CPU 950 @ 3.07GHz, 3066.67 MHz
cpu1: FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DTES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,SSE4.1,SSE4.2,POPCNT,NXE,LONG,LAHF,PERF,ITSC
cpu1: 256KB 64b/line 8-way L2 cache
cpu1: smt 0, core 1, package 0
cpu2 at mainbus0: apid 4 (application processor)
cpu2: Intel(R) Core(TM) i7 CPU 950 @ 3.07GHz, 3066.67 MHz
cpu2: FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DTES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,SSE4.1,SSE4.2,POPCNT,NXE,LONG,LAHF,PERF,ITSC
cpu2: 256KB 64b/line 8-way L2 cache
cpu2: smt 0, core 2, package 0
cpu3 at mainbus0: apid 6 (application processor)
cpu3: Intel(R) Core(TM) i7 CPU 950 @ 3.07GHz, 3066.67 MHz
cpu3: FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DTES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,SSE4.1,SSE4.2,POPCNT,NXE,LONG,LAHF,PERF,ITSC
cpu3: 256KB 64b/line 8-way L2 cache
cpu3: smt 0, core 3, package 0
ioapic0 at mainbus0: apid 1 pa 0xfec00000, version 20, 24 pins
ioapic0: misconfigured as apic 8, remapped to apid 1
acpimcfg0 at acpi0 addr 0xe0000000, bus 0-255
acpihpet0 at acpi0: 14318179 Hz
acpiprt0 at acpi0: bus 0 (PCI0)
acpiprt1 at acpi0: bus 8 (P0P1)
acpiprt2 at acpi0: bus 6 (P0P4)
acpiprt3 at acpi0: bus 7 (P0P5)
acpiprt4 at acpi0: bus -1 (P0P6)
acpiprt5 at acpi0: bus -1 (P0P7)
acpiprt6 at acpi0: bus -1 (P0P8)
acpiprt7 at acpi0: bus -1 (P0P9)
acpiprt8 at acpi0: bus 1 (NPE1)
acpiprt9 at acpi0: bus -1 (NPE2)
acpiprt10 at acpi0: bus 2 (NPE3)
acpiprt11 at acpi0: bus -1 (NPE4)
acpiprt12 at acpi0: bus 3 (NPE5)
acpiprt13 at acpi0: bus -1 (NPE6)
acpiprt14 at acpi0: bus 4 (NPE7)
acpiprt15 at acpi0: bus -1 (NPE8)
acpiprt16 at acpi0: bus 5 (NPE9)
acpiprt17 at acpi0: bus -1 (NPEA)
acpicpu0 at acpi0: C3, C1, PSS
acpicpu1 at acpi0: C3, C1, PSS
acpicpu2 at acpi0: C3, C1, PSS
acpicpu3 at acpi0: C3, C1, PSS
acpibtn0 at acpi0: SLPB
acpibtn1 at acpi0: PWRB
ipmi at mainbus0 not configured
cpu0: Enhanced SpeedStep 3067 MHz: speeds: 3068, 3067, 2933, 2800, 2667, 2533, 2400, 2267, 2133, 2000, 1867, 1733, 1600 MHz
pci0 at mainbus0 bus 0
pchb0 at pci0 dev 0 function 0 "Intel X58 Host" rev 0x22
ppb0 at pci0 dev 1 function 0 "Intel X58 PCIE" rev 0x22: msi
pci1 at ppb0 bus 1
ppb1 at pci0 dev 3 function 0 "Intel X58 PCIE" rev 0x22: msi
pci2 at ppb1 bus 2
ppb2 at pci0 dev 5 function 0 "Intel X58 PCIE" rev 0x22: msi
pci3 at ppb2 bus 3
ppb3 at pci0 dev 7 function 0 "Intel X58 PCIE" rev 0x22: msi
pci4 at ppb3 bus 4
ppb4 at pci0 dev 9 function 0 "Intel X58 PCIE" rev 0x22: msi
pci5 at ppb4 bus 5
"Intel X58 Misc" rev 0x22 at pci0 dev 20 function 0 not configured
"Intel X58 GPIO" rev 0x22 at pci0 dev 20 function 1 not configured
"Intel X58 RAS" rev 0x22 at pci0 dev 20 function 2 not configured
"Intel X58 Throttle" rev 0x22 at pci0 dev 20 function 3 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 0 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 1 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 2 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 3 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 4 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 5 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 6 not configured
"Intel X58 QuickData" rev 0x22 at pci0 dev 22 function 7 not configured
uhci0 at pci0 dev 26 function 0 "Intel 82801JI USB" rev 0x00: apic 1 int 16 uhci1 at pci0 dev 26 function 1 "Intel 82801JI USB" rev 0x00: apic 1 int 21 uhci2 at pci0 dev 26 function 2 "Intel 82801JI USB" rev 0x00: apic 1 int 19 ehci0 at pci0 dev 26 function 7 "Intel 82801JI USB" rev 0x00: apic 1 int 18
usb0 at ehci0: USB revision 2.0
uhub0 at usb0 "Intel EHCI root hub" rev 2.00/1.00 addr 1
ppb5 at pci0 dev 28 function 0 "Intel 82801JI PCIE" rev 0x00: msi
pci6 at ppb5 bus 6
em0 at pci6 dev 0 function 0 "Intel 82574L" rev 0x00: msi, address 00:25:90:14:43:54
ppb6 at pci0 dev 28 function 1 "Intel 82801JI PCIE" rev 0x00: msi
pci7 at ppb6 bus 7
em1 at pci7 dev 0 function 0 "Intel 82574L" rev 0x00: msi, address 00:25:90:14:43:55 uhci3 at pci0 dev 29 function 0 "Intel 82801JI USB" rev 0x00: apic 1 int 23 uhci4 at pci0 dev 29 function 1 "Intel 82801JI USB" rev 0x00: apic 1 int 19 uhci5 at pci0 dev 29 function 2 "Intel 82801JI USB" rev 0x00: apic 1 int 18 ehci1 at pci0 dev 29 function 7 "Intel 82801JI USB" rev 0x00: apic 1 int 23
usb1 at ehci1: USB revision 2.0
uhub1 at usb1 "Intel EHCI root hub" rev 2.00/1.00 addr 1
ppb7 at pci0 dev 30 function 0 "Intel 82801BA Hub-to-PCI" rev 0x90
pci8 at ppb7 bus 8
vga1 at pci8 dev 4 function 0 "Matrox MGA G200eW" rev 0x0a
wsdisplay0 at vga1 mux 1: console (80x25, vt100 emulation)
wsdisplay0: screen 1-5 added (80x25, vt100 emulation)
pcib0 at pci0 dev 31 function 0 "Intel 82801JIR LPC" rev 0x00
ahci0 at pci0 dev 31 function 2 "Intel 82801JI AHCI" rev 0x00: msi, AHCI 1.2
scsibus1 at ahci0: 32 targets
sd0 at scsibus1 targ 0 lun 0: <ATA, HITACHI HTS54168, SB2I> SCSI3 0/direct fixed naa.5000cca51cdb01e3
sd0: 76319MB, 512 bytes/sector, 156301488 sectors
sd1 at scsibus1 targ 2 lun 0: <ATA, SAMSUNG MZMPA016, AXM2> SCSI3 0/direct fixed t10.ATA_SAMSUNG_MZMPA016HMCD-000L1_S11BNEACB03878_
sd1: 15272MB, 512 bytes/sector, 31277232 sectors, thin
ichiic0 at pci0 dev 31 function 3 "Intel 82801JI SMBus" rev 0x00: apic 1 int 18
iic0 at ichiic0
nvt0 at iic0 addr 0x2e: W83795ADG
spdmem0 at iic0 addr 0x50: 1GB DDR3 SDRAM PC3-10600
spdmem1 at iic0 addr 0x51: 1GB DDR3 SDRAM PC3-10600
spdmem2 at iic0 addr 0x52: 1GB DDR3 SDRAM PC3-10600
spdmem3 at iic0 addr 0x53: 1GB DDR3 SDRAM PC3-10600
spdmem4 at iic0 addr 0x54: 1GB DDR3 SDRAM PC3-10600
spdmem5 at iic0 addr 0x55: 1GB DDR3 SDRAM PC3-10600
usb2 at uhci0: USB revision 1.0
uhub2 at usb2 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb3 at uhci1: USB revision 1.0
uhub3 at usb3 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb4 at uhci2: USB revision 1.0
uhub4 at usb4 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb5 at uhci3: USB revision 1.0
uhub5 at usb5 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb6 at uhci4: USB revision 1.0
uhub6 at usb6 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb7 at uhci5: USB revision 1.0
uhub7 at usb7 "Intel UHCI root hub" rev 1.00/1.00 addr 1
isa0 at pcib0
isadma0 at isa0
com0 at isa0 port 0x3f8/8 irq 4: ns16550a, 16 byte fifo
com0: console
com1 at isa0 port 0x2f8/8 irq 3: ns16550a, 16 byte fifo
pckbc0 at isa0 port 0x60/5
pckbd0 at pckbc0 (kbd slot)
pckbc0: using irq 1 for kbd slot
wskbd0 at pckbd0: console keyboard, using wsdisplay0
pcppi0 at isa0 port 0x61
spkr0 at pcppi0
wbsio0 at isa0 port 0x2e/2: W83627DHG-P rev 0x73
lm1 at wbsio0 port 0xca0/8: W83627DHG
uftdi0 at uhub2 port 2 "FTDI FT232R USB UART" rev 2.00/6.00 addr 2
ucom0 at uftdi0 portno 1
vscsi0 at root
scsibus2 at vscsi0: 256 targets
softraid0 at root
scsibus3 at softraid0: 256 targets
sd2 at scsibus3 targ 1 lun 0: <OPENBSD, SR RAID 1, 005> SCSI2 0/direct fixed
sd2: 15264MB, 512 bytes/sector, 31261898 sectors
root on sd2a (84fdd34aaf0b5d78.a) swap on sd2b dump on sd2b

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