I'm running mod_perl 2 on RedHat with Apache 2.0.44 and I'm using NamedBased Virtual Hosting in apache (so I have a number of virtual hosts and apache directs properly based on hostname).
also make sure to upgrade your mod_perl 2 to the latest stable version 1.99_08 or even better the cvs one. The one coming with RH is too old. Save yourself troubles.
http://perl.apache.org/download/index.html
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