Firstly, I only do direct-drive.

I dont use driver chips. Instead, I use either NPN or NMOS discrete 
devices, because I can ensure constant-current thru the cathode.
Using a dropping-resistor will result in some current-variation due to the 
tube's characteristics, or supply voltage variation.

For larger tubes, you may want to tweak the cathode-current. For example, a 
'1' numeral will require less current than an '8'. This is possible with 
per-cathode drivers. Basically, the current-limiting resistor is placed 
between source and ground for an NMOS driver, or emitter and ground for an 
NPN driver. The resistor provides current-feedback.

NPN Driver. I use this on my neon watch because the supply voltage of 3.7V 
is too low for high-voltage NMOS devices. To calculate the emitter resistor 
value, R=(Vsupply-0.7)/current.  If current is in mA, R is in k-ohms. If 
you want 335uA for a 3.7V supply, then use 8.9K (the recommended current 
for an SP-151 display). Be aware that most of the heat will be dissipated 
by the NPN device, not the resistor.

NMOS driver. The topology is similar, but the gate-source threshold voltage 
has more variation than Vbe for an NPN transistor. I use 12V for my 
big-clock, and Vgs is around 3.4V. The driver logic runs at 12V, so 
variations in Vgs have relatively small effect on the cathode current.

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