I strongly suggest using the IEC connectors with integrated fuses; it will 
protect against internal wiring shorts or other bad things that can happen. 
My most-recent projects use these, but I have not retrofitted all of my 
older projects.

I have several PCB's that bring raw 120VAC onboard, but the first thing 
that happens is both the hot & neutral lines are fused with the 
lowest-rated fuse that will work reliably. Those fuses are located right 
next to the power connector.

My first nixie clock design also uses 4000 CMOS, with no transformer. 
Everything is run from the AC line. I added a lot of extra protection (RC 
filter, varistor, metal fire-barrier in the case, way-over-rated 
electrolytics). It's worked flawlessly for years.

There's no need to be afraid of line voltage inside your projects; just be 
sure to use good design practices and plenty of paranoia.

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