So I was originally looking at the Microchip HV513 
<https://www.microchip.com/wwwproducts/en/HV513>.  It's a 250V totem pole 
driver with 5V input logic and a latch.  Was going to do a quick sketch of 
what I had in mind for the output, but haven't had the time to get round to 
it.

I was planning to not multiplex my nixies, probably leaving all cathodes 
connected directly to the HV line, and placing current liming resistors on 
the cathodes.  Was interested to see if I'd need to tweak any of the 
individual resistor values uniform current/brightness.

If I implemented only a low side switch, I was looking at something like 
the MMBTA42, available from a few manufacturers and is good for 300V, but I 
haven't yet found any information about leakage currents when the device is 
off.  Alternatively I think I found a mosfet or two with sufficient V(DS) 
and logic level switching, but I need to recheck the D-S leakage.

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