I was able to install nessy sucessfully on my CentOS 5 machines using the rpm (which already have Python 2.7 installed in /usr/local/) using the following steps as root. Then you just have to make sure that the python2.7 executable is first in your path and chmod +x /usr/bin/nessy

cd /usr/local/src
wget 
http://downloads.sourceforge.net/project/numpy/NumPy/1.6.1/numpy-1.6.1.tar.gz?r=http%3A%2F%2Fsourceforge.net%2Fprojects%2Fnumpy%2Ffiles%2FNumPy%2F&ts=1322731932&use_mirror=kent
wget 
http://downloads.sourceforge.net/project/scipy/scipy/0.10.0/scipy-0.10.0.tar.gz?r=http%3A%2F%2Fsourceforge.net%2Fprojects%2Fscipy%2Ffiles%2F&ts=1322731959&use_mirror=kent
wget 
http://downloads.sourceforge.net/project/matplotlib/matplotlib/matplotlib-1.1.0/matplotlib-1.1.0.tar.gz?r=http%3A%2F%2Fsourceforge.net%2Fprojects%2Fmatplotlib%2Ffiles%2Fmatplotlib%2Fmatplotlib-1.1.0%2F&ts=1322741534&use_mirror=kent
wget http://downloads.sourceforge.net/wxpython/wxPython-src-2.9.2.4.tar.bz2


yum install blas-devel lapack-devel atlas-devel

tar xzvf numpy-1.6.1.tar.gz
cd numpy-1.6.1
/usr/local/bin/python2.7 setup.py install
cd ../

tar xzvf scipy-0.10.0.tar.gz
cd scipy-0.10.0
/usr/local/bin/python2.7 setup.py install
cd ../

tar xzvf matplotlib-1.1.0.tar.gz
cd matplotlib-1.1.0
/usr/local/bin/python2.7 setup.py install
cd ../


#yum install gstreamer-devel gconfmm26-devel #does not appear to fix gstreamer dependency
tar xjvf wxPython-src-2.9.2.4.tar.bz2
cd wxPython-src-2.9.2.4/wxPython
/usr/local/bin/python2.7 build-wxpython.py --build_dir=../bld --install
# if gstreamer error appears
nedit ../build/tools/build-wxwidgets.py &
# remove --enable-mediactrl line
/usr/local/bin/python2.7 build-wxpython.py --build_dir=../bld --install
# create an /etc/ld.so.conf.d/wxPython.conf containing /usr/local/lib
# and run ldconfig to pick up the libraries


Dr. Brian O. Smith --------------------------- Brian Smith at glasgow ac uk
Institute of Molecular, Cell and Systems Biology & School of Life Sciences,
          College of Medical, Veterinary & Life Sciences,
  Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
Tel: 0141 330 5167/6459/3089                        Fax: 0141 330 4600
----------------------------------------------------------------------
The University of Glasgow, charity number SC004401

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