Hello all I work with small number of pediatric inpatients with few samples from each patient of various age and weights.
I am a novice in using NONMEM. I would appreciate advice on fitting the data using various dose inputs - should we normalize the dose and other parameters by weights ? Since the range is large in my datasets, the variability could be quite large without using /kg dosing. Example 24 patients with different age and size (paediatrics) on Cyclosporin IV infusion over 2 hours with 5 levels taken at similar times post 1st (and only dose). Although dose at 1.5mg/kg, the actual amount of dose given for each patient varies. Looking at the raw data and log conc vs time graphs, it appeared 2-compartment would be suitable. However, Volume of distributions and clearances varies with units without normalization to body weight (kg) or body size (BSA). Any thoughts or suggestions would be much appreciated. Thank You! Winnie Winnie Seto, BScPhm, PharmD, MSc, ACPR, R.Ph. Therapeutic Drug Monitoring Coordinator & Critical Care Unit Pharmacist The Hospital for Sick Children 555 University Avenue Toronto, Ontario Canada M5G 1X8 phone: 416-813-6236 fax: 416-813-5880 This is a medical communication. This e-mail message is for the sole use of the intended recipient(s) and may contain privileged and confidential information. Any unauthorized review, use, disclosure or distribution is prohibited. If you are not the intended recipient, please contact the author by reply email and destroy all original and copies of this email message.
