Dear Winnie,
it is not advisable to "normalize" the data to body weight or body
surface area.
Instead, you should build a basic model without weight/BSA and try to
use weight or BSA as covariate for the pharmacokinetic parameters. Also,
you should test the allometric scaling approach (see Anderson et al.
Clin Pharmacokin 33(5): 313-327 (1997).
With best regards
Georg
--
Hochschuldozent Dr. Georg Hempel
Institut fuer Pharmazeutische und Medizinische Chemie
- Klinische Pharmazie -
Hittorfstr. 58-62
48149 Muenster, Germany
E-mail: [EMAIL PROTECTED]
