try an additive IIV and/or RV, depending on your MOA and measurement error pattern.
-------------------------------------------------------------------------- Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful. -----Original Message----- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Vinogradova Svetlana Sent: Wednesday, September 21, 2011 8:26 AM To: nmusers@globomaxnm.com Subject: [NMusers] analysis of non-positive DV Dear NONMEM users, I'm analyzing a dataset of 4 patients, there are 2 types of observations for each patient - vehicle (say baseline) and dose (treatment). We want to analyze our dataset in terms of (treatment-baseline). So I've modified my dataset, and now I have only one "column" of observations for each patient: DV= (treatment-baseline). But now I have some problems because I have some negitive values in DV column. In case of some models it results in problems, for example: TEFF = TBAS + (TSLP*CP)**TALP so TSLP should be positive but it's not that right... Maybe there are some common methods to deal with this case? Thanks a lot, Svetlana
