I forgot to mention another (architectural) option: split an application into 
frontend provided by JS in the browser and a backend, which takes care of the 
business logic and handles tokens and API access. Replay detection at the 
interface between SPA and backend can utilize standard web techniques (see 
OWASP). The backend in turn can use mTLS for sender constraining.

> Am 01.12.2018 um 15:34 schrieb Torsten Lodderstedt <tors...@lodderstedt.net>:
> 
> IMHO the best mechanism at hand currently to cope with token leakage/replay 
> in SPAs is to use refresh tokens (rotating w/ replay detection) and issue 
> short living and privilege restricted access tokens.
> 
> Sender constrained access tokens in SPAs need adoption of token binding or 
> alternative mechanism. mtls could potentially work in deployments with 
> automated cert rollout but browser UX and interplay with fetch needs some 
> work. We potentially must consider to warm up application level PoP 
> mechanisms in conjunction with web crypto. Another path to be evaluated could 
> be web auth.
> 
>> Am 01.12.2018 um 10:15 schrieb Hannes Tschofenig <hannes.tschofe...@arm.com>:
>> 
>> I share the concern Brian has, which is also the conclusion I came up with 
>> in my other email sent a few minutes ago.
>>  
>> From: OAuth <oauth-boun...@ietf.org> On Behalf Of Brian Campbell
>> Sent: Friday, November 30, 2018 11:43 PM
>> To: Torsten Lodderstedt <tors...@lodderstedt.net>
>> Cc: oauth <oauth@ietf.org>
>> Subject: Re: [OAUTH-WG] draft-parecki-oauth-browser-based-apps-00
>>  
>>  
>> 
>> On Sat, Nov 17, 2018 at 4:07 AM Torsten Lodderstedt 
>> <tors...@lodderstedt.net> wrote:
>> > Am 15.11.2018 um 23:01 schrieb Brock Allen <brockal...@gmail.com>:
>> > 
>> > So you mean at the resource server ensuring the token was really issued to 
>> > the client? Isn't that an inherent limitation of all bearer tokens (modulo 
>> > HTTP token binding, which is still some time off)?
>> 
>> Sure. That’s why the Security BCP recommends use of TLS-based methods for 
>> sender constraining access tokens 
>> (https://tools.ietf.org/html/draft-ietf-oauth-security-topics-09#section-2..2).
>>  Token Binding for OAuth 
>> (https://tools.ietf.org/html/draft-ietf-oauth-token-binding-08) as well as 
>> Mutual TLS for OAuth (https://tools.ietf.org/html/draft-ietf-oauth-mtls-12) 
>> are the options available.
>>  
>> Unfortunately even when using the token endpoint, for SPA / in-browser 
>> client applications, the potential mechanisms for sender/key-constraining 
>> access tokens don't work very well or maybe don't work at all. So I don't 
>> know that the recommendation is very realistic.
>>  
>> 
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