The first instance
myhostname = mail.mysever.com
inet_interfaces = 192.168.56.102
The second instance 

myhostname = mail.mysever2.com
inet_interfaces = 192.168.1.60



> I have also error when reloading the second instance 
> fatal: bind 192.168.1.60 port 25: Address already in use
> but each one of instances has different myhostname ans inet_interfaces
> settings

The error message "Address already in use" PROVES that you have
multiple mail servers instances with the SAME IP address.

If you want real help, then you must show real evidence of your
myhostname and inet_interfaces settings, not "yes they are different".

        Wietse

> 
> > When I try to send mail to account from the second instance I get this
> error
> > in mallog where myserver2 is virtual domain in the second postfix
instance
> > 
> > relay=none, delay=13, delays=13/0.03/0/0, dsn=5.4.6, status=bounced
(mail
> > for myserver2.com loops back to myself)
> 
> Each instance MUST have a unique myhostname setting.
> 
> Each instance MUST have a unique inet_interfaces address list.
> 
> Otherwise, the Postfix SMTP client will report "mail loops back to
> myself" errors.
> 
>       Wietse
> 
> 

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