Darren,

> Also, while we recognize
> that there are different qualities that can be ascribed to a basically
> identical biochemical entity in different structural conformations or
> states of ligand binding, we are not attempting (at least in the
> beginning) to describe these structural conformations or bound vs
> unbound forms.

Indeed, while conformation is an important quality of molecular
structure, it does not fundamentally change the nature of the molecule.
i.e. a protein in a bound or unbound state should still be considered
the same protein. 

Cheers,

-=Michel=-
 

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