Michel_Dumontier wrote:
Darren,
Also, while we recognize
that there are different qualities that can be ascribed to a basically
identical biochemical entity in different structural conformations or
states of ligand binding, we are not attempting (at least in the
beginning) to describe these structural conformations or bound vs
unbound forms.
Indeed, while conformation is an important quality of molecular
structure, it does not fundamentally change the nature of the molecule.
i.e. a protein in a bound or unbound state should still be considered
the same protein.
what about denaturation? is the nature (what nature, by the way?) of a
protein not fundamentally different in its native vs. denaturated state?
vQ
