Peter wrote:
> Using both SQL and subsumption you can automatically find things like this: 
> "find all disorders that are a kind of adverse drug reaction where drug is a 
> subtype of antibiotic and was given for a kind of gram negative bacterial 
> infection of the digestive system". 

Simple subsumption such as that can be inferred by basic, RDFS-type reasoning. 
I don't see any potential problems caused by OWL's open world assumption here 
(please point them out if there are any).
Indeed, the open-world assumption of OWL can make creating expressive 
ontologies and using reasoners tricky. However, I do not see why the same 
should be true for using RDF, basic RDFS subsumptions and SPARQL. Could you 
provide some examples?

If we wanted to use more expressive ontologies with "intensional" entities 
(i.e., defined classes) in the overall system, we could simply run a reasoner 
and materialize the inferred statements for each ontology before it is 
'shipped' for use by other systems. These other systems could then use simple 
RDF(S) and SPARQL (and maybe SPARQL rules), without the performance issues and 
potential unexpected consequences of open-world reasoning with expressive OWL 
ontologies. Specifying if and how exactly each specific node should be reasoned 
upon sounds so complex that I cannot imagine it working in any practical 
setting.

Best,
Matthias

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