It depends on how much time do you want to spend fighting with the framework. I usually do not recommend Zope, unless you want to make a career as a Zope consultant. If you have to interact with a relational database, your life with Zope may be hard: http://www.jrandolph.com/blog/?p=23
For easy of use nothing beats CherryPy, but I am not sure how stable it is. Quixote is nice and small, and pretty easy to use too. Many likes Django and TurboGears. Zope and Twisted are for people who have a lot of time to invest. Michele Simionato -- http://mail.python.org/mailman/listinfo/python-list