I'm also experiencing the same issue. Whenever my laptop resumes after have being suspended, the sys-usb is frozen and all USB devices attached to it fail to work. I have to kill the appvm and start it again. This only affects the sys-usb though, the sys-net is working fine during the resume. The issue that describes this problem - https://github.com/QubesOS/qubes-issues/issues/3142 (https://github.com/QubesOS/qubes-issues/issues/3142) - was closed but the problem still persists.
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