Hi Martin,

Martin Turcotte wrote:
Hi I am running some linear and non-linear mixed effect models and would like 
to do some planned contrasts (a priori contrasts)

I have looked in the help and in many forums and it seems possible to do so but don't understand how to write the function and I couldn't find an example in Pinheiro and Bates. lme {nlme} has a contrasts argument but I can't understand how to code it.
Here is a simple example of my working lme model:
dependent variable: APHIDS: log (number of aphids)
Fixed effects: DAY (time)   and  TREATMENT ( 6 different aphid treatments)
Random effects: POPULATION (each population is counted through time)

lme.fit<-lme(log(APHIDS)~ DAY*TREATMENT, random = ~ DAY|                     
POPULATION,data= aphid.data)

My hypothesis testing focuses on comparing Treatments ~ 1 and 4 , and eventually 2 vs 5, and 3 vs 6. Q1: How can I do planned contrasts on these pairs for the main effect of TREATMENT?
Q2: Can I also do this for the interaction term (DAY*TREATMENT)?

Q3: Would this code work for a non-linear mixed effect model    nlme( )

I would have a look at the multcomp package which allows for
defining contrasts in a very convenient way and can deal a.o.
with lme (from nlme) and mer (from lme4) objects.

http://cran.r-project.org/web/packages/multcomp/index.html

The package comes with several vignettes with example uses
(also an lmer one IIRC).

Best,
Tobias

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