As a former XO-1 owner I can tell you the smaller wheels accelerate faster and are probably a little easier on a slow grinding climb while loaded, but in the other end of the spectrum the larger wheels seem to maintain momentum better. I might go 26" if traveling to somewhere outof tge way, but otherwise I would choose a wheel size proportional to you height. I rode 26" almost exclusively for 25 years, but I am loving 650B now & that is one thing I look for, but it might not make sense touring China or South America.
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