MTB 11-speed cassettes with 40t large cog are pretty common these days, and 
I've found you don't even need an MTB RD to use them. The latest Ultegra 
GS R8000 RD will change across an 11-40 no problem with the B-screw most of 
the way in. Also, using the MTB cassettes has the advantage that you don't 
need a new hub with the longer 11-speed freehub body and more wheel dish to 
fit an 11-speed cassette - the large 11-speed cassettes fit on older 
8/9/10-speed hubs because the large inner cog can overhang the freehub more 
to the inside without the RD hitting the spokes in bottom gear. I fitted 
one of these cassettes and a Sugino OX crank with 39-26 chainrings to my 
wife's road bike, which gives her gears from 93" down to 17". She spins up 
the hills and annoys a few of the big beefy blokes who are grunting up in 
their hero gearing...

YT video showing the Ultegra RD and 40t cassette: 
https://www.youtube.com/watch?v=roUXWvAN-9k.

Nick

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