Hi,

I am just reporting on something I saw over the weekend. A samtools
sort command executed on Friday was still running this morning on a
file that should have taken a relatively short time to sort.

The input file is about 241M, and this morning, samtools-0.1.18 sort
was producing a file that was 1000x bigger, 236G and growing when I
killed it.

samtools

Program: samtools (Tools for alignments in the SAM format)
Version: 0.1.18 (r982:295)

Usage:   samtools <command> [options]

Command: view        SAM<->BAM conversion
         sort        sort alignment file
         mpileup     multi-way pileup
         depth       compute the depth
         faidx       index/extract FASTA
         tview       text alignment viewer
         index       index alignment
         idxstats    BAM index stats (r595 or later)
         fixmate     fix mate information
         flagstat    simple stats
         calmd       recalculate MD/NM tags and '=' bases
         merge       merge sorted alignments
         rmdup       remove PCR duplicates
         reheader    replace BAM header
         cat         concatenate BAMs
         targetcut   cut fosmid regions (for fosmid pool only)
         phase       phase heterozygotes


Not sure if this weird behaviour has been seen before, I am just
reporting it here to log what happened. I will try the same file with
a newer version of samtools as well as sambamba to see if it's
something inherent to the file.

Thanks,

Albert Vilella, PhD.

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