Hi Albert,

You are using a very old version of samtools, can you try
samtools v0.1.19 (last release before the htslib changes)
or try the current release samtools v1.2 (but be careful
as some of the options were changed).

Peter


On Mon, Jul 6, 2015 at 9:29 AM, Albert Vilella <[email protected]> wrote:
> Hi,
>
> I am just reporting on something I saw over the weekend. A samtools
> sort command executed on Friday was still running this morning on a
> file that should have taken a relatively short time to sort.
>
> The input file is about 241M, and this morning, samtools-0.1.18 sort
> was producing a file that was 1000x bigger, 236G and growing when I
> killed it.
>
> samtools
>
> Program: samtools (Tools for alignments in the SAM format)
> Version: 0.1.18 (r982:295)
>
> Usage:   samtools <command> [options]
>
> Command: view        SAM<->BAM conversion
>          sort        sort alignment file
>          mpileup     multi-way pileup
>          depth       compute the depth
>          faidx       index/extract FASTA
>          tview       text alignment viewer
>          index       index alignment
>          idxstats    BAM index stats (r595 or later)
>          fixmate     fix mate information
>          flagstat    simple stats
>          calmd       recalculate MD/NM tags and '=' bases
>          merge       merge sorted alignments
>          rmdup       remove PCR duplicates
>          reheader    replace BAM header
>          cat         concatenate BAMs
>          targetcut   cut fosmid regions (for fosmid pool only)
>          phase       phase heterozygotes
>
>
> Not sure if this weird behaviour has been seen before, I am just
> reporting it here to log what happened. I will try the same file with
> a newer version of samtools as well as sambamba to see if it's
> something inherent to the file.
>
> Thanks,
>
> Albert Vilella, PhD.
>
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