Now why does the skeptic in me want to say, after reading this, "How long has this been on the back shelf?"
On Mon, Jul 5, 2010 at 6:11 PM, Mr. Worf <hellomahog...@gmail.com> wrote: > > > Nanoparticle vaccine cures type 1 diabetes in mice > > By Darren Quick <http://www.gizmag.com/author/darren-quick/> > > *00:10 April 9, 2010* > > 5 Comments <http://www.gizmag.com/type-1-diabetes-vaccine/14762/#comments> > [image: A new nanotechnology-based vaccine offers the hope of curing > type 1 diabetes in > humans]<http://www.gizmag.com/type-1-diabetes-vaccine/14762/picture/113268/> > > A new nanotechnology-based vaccine offers the hope of curing type 1 > diabetes in humans > The Diabetes > Lies<http://googleads.g.doubleclick.net/aclk?sa=l&ai=BUPTkMFgyTIWcNIqWjQTjiIT0A73Fj-MBtY2S7hLAjbcBsPpPEAEYASCz3PoBKAQ4AFC9zez8A2DJjvCGyKOgGaABzfqy7wOyAQ53d3cuZ2l6bWFnLmNvbboBCjMwMHgyNTBfanPIAQHaATRodHRwOi8vd3d3Lmdpem1hZy5jb20vdHlwZS0xLWRpYWJldGVzLXZhY2NpbmUvMTQ3NjIvgAIBqAMB6AP2BOgDLegD_AHoA_8B9QMCAABE&num=1&sig=AGiWqtxBObJ8_wIxjIwtrj2MB8jouN1OKQ&client=ca-pub-1607124478120364&adurl=http://www.offeredby.net/silver/rdm.cfm%3Ftrkid%3D21726S205993600>- > DrWhitaker.com<http://googleads.g.doubleclick.net/aclk?sa=l&ai=BUPTkMFgyTIWcNIqWjQTjiIT0A73Fj-MBtY2S7hLAjbcBsPpPEAEYASCz3PoBKAQ4AFC9zez8A2DJjvCGyKOgGaABzfqy7wOyAQ53d3cuZ2l6bWFnLmNvbboBCjMwMHgyNTBfanPIAQHaATRodHRwOi8vd3d3Lmdpem1hZy5jb20vdHlwZS0xLWRpYWJldGVzLXZhY2NpbmUvMTQ3NjIvgAIBqAMB6AP2BOgDLegD_AHoA_8B9QMCAABE&num=1&sig=AGiWqtxBObJ8_wIxjIwtrj2MB8jouN1OKQ&client=ca-pub-1607124478120364&adurl=http://www.offeredby.net/silver/rdm.cfm%3Ftrkid%3D21726S205993600> > Learn About The 7 Deadly Diabetes Lies from Dr. Julian Whitaker. > Diabetes > Treatment<http://googleads.g.doubleclick.net/aclk?sa=l&ai=BkoF6MFgyTIWcNIqWjQTjiIT0A828rscBld26oBLAjbcBwO5tEAIYAiCz3PoBKAQ4AFC59Yn_B2DJjvCGyKOgGbIBDnd3dy5naXptYWcuY29tugEKMzAweDI1MF9qc8gBAdoBNGh0dHA6Ly93d3cuZ2l6bWFnLmNvbS90eXBlLTEtZGlhYmV0ZXMtdmFjY2luZS8xNDc2Mi-AAgHIAsOkkguoAwHoA_YE6AMt6AP8AegD_wH1AwIAAEQ&num=2&sig=AGiWqtyADlYSFC3oxwARgsz_SOcR5jmACA&client=ca-pub-1607124478120364&adurl=http://ad.doubleclick.net/clk%3B206168028%3B22459019%3Be%3Fhttp://www.lantus.com/why_lantus/why_lantus.aspx%3FWT.mc_id%3DLNWB558%26WT.srch%3D1>- > 24HourInsulin.com<http://googleads.g.doubleclick.net/aclk?sa=l&ai=BkoF6MFgyTIWcNIqWjQTjiIT0A828rscBld26oBLAjbcBwO5tEAIYAiCz3PoBKAQ4AFC59Yn_B2DJjvCGyKOgGbIBDnd3dy5naXptYWcuY29tugEKMzAweDI1MF9qc8gBAdoBNGh0dHA6Ly93d3cuZ2l6bWFnLmNvbS90eXBlLTEtZGlhYmV0ZXMtdmFjY2luZS8xNDc2Mi-AAgHIAsOkkguoAwHoA_YE6AMt6AP8AegD_wH1AwIAAEQ&num=2&sig=AGiWqtyADlYSFC3oxwARgsz_SOcR5jmACA&client=ca-pub-1607124478120364&adurl=http://ad.doubleclick.net/clk%3B206168028%3B22459019%3Be%3Fhttp://www.lantus.com/why_lantus/why_lantus.aspx%3FWT.mc_id%3DLNWB558%26WT.srch%3D1> > Blood Sugar Levels Matter. 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Find Out What Your Doctor Isn't Telling You About Diabetes! > Ads by > Google<http://www.google.com/url?ct=abg&q=https://www.google.com/adsense/support/bin/request.py%3Fcontact%3Dabg_afc%26url%3Dhttp://www.gizmag.com/type-1-diabetes-vaccine/14762/%26hl%3Den%26client%3Dca-pub-1607124478120364%26adU%3DDrWhitaker.com%26adT%3DThe%2BDiabetes%2BLies%26adU%3D24HourInsulin.com%26adT%3DDiabetes%2BTreatment%26adU%3Dwww.DiabetesTrialNet.org/%26adT%3DType%2B1%2BDiabetes%26adU%3Dtcoyd.org%26adT%3D%257BDealing%2BWith%2BDiabetes%253F%257D%26gl%3DUS&usg=AFQjCNFhD7fyOEcONHNF8H7GGZtGT2vVhA> > > According to the American Diabetes > Association<http://www.diabetes.org/diabetes-basics/diabetes-statistics/>around > one in every 400 to 600 children and adolescents has type 1 diabetes > – also known as IDDM, or juvenile diabetes. Currently there is no known way > to prevent the disease which requires sufferers to administer insulin > usually via injection or a pump. Using a nanotechnology-based "vaccine," > researchers were able to successfully cure mice with type 1 diabetes and > slow the onset of the disease. > > Type 1 diabetes is caused when certain white blood cells (called T cells) > mistakenly attack and destroy the insulin-producing beta cells in the > pancreas. The subsequent lack of insulin leads to increased blood and urine > glucose and is fatal unless treated with insulin. > > "Essentially there is an internal tug-of-war between aggressive T-cells > that want to cause the disease and weaker T cells that want to stop it from > occurring," said Dr. Santamaria from the Julia McFarlane Diabetes > Researchers Center at the University of Calgary <http://www.ucalgary.ca/>, > Alberta, who is a Juvenile Diabetes Research > Foundation<http://www.jdrf.org/>(JDRF) Scholar. > > The researchers were looking to specifically stop the autoimmune response > that causes type 1 diabetes without damaging the immune cells that provide > protection against infections – what is called an "antigen-specific" > immunotherapy. They developed a unique vaccine comprised of nanoparticles, > which are thousands of times smaller than the size of a cell. These > nanoparticles are coated with protein fragments – peptides – specific to > type 1 diabetes that are bound to molecules (MHC molecules) that play a > critical role in presenting peptides to T cells. > > The nanoparticle vaccine worked by expanding the number of peptide-specific > regulatory T cells that suppressed the aggressive immune attack that > destroys beta cells. The expanded peptide-specific regulatory cells shut > down the autoimmune attack by preventing aggressive autoimmune cells from > being stimulated by either the peptide contained in the vaccine or by any > other type 1 diabetes autoantigen presented simultaneously on the same > antigen presenting cell. > > The research also provided an important insight into the ability to > translate these findings in mice into therapeutics for people with diabetes: > nanoparticles that contained human diabetes-related molecules were able to > restore normal blood sugar levels in a humanized mouse model of diabetes. > > According to Teodora Staeva, Ph.D., JDRF Program Director of Immune > Therapies, a key finding from the Alberta study is that only the immune > cells specifically focused on aggressively destroying beta cells (or, > alternatively, regulating these cells) responded to the antigen-specific > nanoparticle vaccine. That means the treatment did not compromise the rest > of the immune system – a key consideration for the treatment to be safe and > effective in an otherwise healthy person with type 1 diabetes. > > "The potential that nanoparticle vaccine therapy holds in reversing the > immune attack without generally suppressing the immune system is > significant," said Dr. Staeva. "Dr. Santamaria's research has provided both > insight into pathways for developing new immunotherapies and > proof-of-concept of a specific therapy that exploits these pathways for > preventing and reversing type 1 diabetes." > > Dr. Santamaria noted that the study had implications for other autoimmune > diseases beyond type 1 diabetes. "If the paradigm on which this nanovaccine > is based holds true in other chronic autoimmune diseases, such as multiple > sclerosis, rheumatoid arthritis, and others, nanovaccines might find general > applicability in autoimmunity," he said. > > The nanoparticle vaccine technology used in the study has been licensed by > Parvus Therapeutics, Inc., a biotechnology company that is focused on the > development and commercialization of the technology for the potential > treatment of type 1 diabetes. > > The study, conducted at the University of Calgary in Alberta, Canada, > appears in the online edition of the scientific journal > *Immunity<http://www.cell.com/immunity/home> > *. > > > -- > Celebrating 10 years of bringing diversity to perversity! > Mahogany at: http://groups.yahoo.com/group/mahogany_pleasures_of_darkness/ > > -- "If all the world's a stage and we are merely players, who the bloody hell wrote the script?" -- Charles E Grant http://www.youtube.com/watch?v=fQUxw9aUVik
