Well, we can't say "sitting there"... it's probably always been available for those with the ducats.
On Tue, Jul 6, 2010 at 3:46 PM, Mr. Worf <hellomahog...@gmail.com> wrote: > > > Good question. 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Using a nanotechnology-based "vaccine," >>> researchers were able to successfully cure mice with type 1 diabetes and >>> slow the onset of the disease. >>> >>> Type 1 diabetes is caused when certain white blood cells (called T cells) >>> mistakenly attack and destroy the insulin-producing beta cells in the >>> pancreas. The subsequent lack of insulin leads to increased blood and urine >>> glucose and is fatal unless treated with insulin. >>> >>> "Essentially there is an internal tug-of-war between aggressive T-cells >>> that want to cause the disease and weaker T cells that want to stop it from >>> occurring," said Dr. Santamaria from the Julia McFarlane Diabetes >>> Researchers Center at the University of Calgary<http://www.ucalgary.ca/>, >>> Alberta, who is a Juvenile Diabetes Research >>> Foundation<http://www.jdrf.org/>(JDRF) Scholar. >>> >>> The researchers were looking to specifically stop the autoimmune response >>> that causes type 1 diabetes without damaging the immune cells that provide >>> protection against infections – what is called an "antigen-specific" >>> immunotherapy. They developed a unique vaccine comprised of nanoparticles, >>> which are thousands of times smaller than the size of a cell. These >>> nanoparticles are coated with protein fragments – peptides – specific to >>> type 1 diabetes that are bound to molecules (MHC molecules) that play a >>> critical role in presenting peptides to T cells. >>> >>> The nanoparticle vaccine worked by expanding the number of >>> peptide-specific regulatory T cells that suppressed the aggressive immune >>> attack that destroys beta cells. The expanded peptide-specific regulatory >>> cells shut down the autoimmune attack by preventing aggressive autoimmune >>> cells from being stimulated by either the peptide contained in the vaccine >>> or by any other type 1 diabetes autoantigen presented simultaneously on the >>> same antigen presenting cell. >>> >>> The research also provided an important insight into the ability to >>> translate these findings in mice into therapeutics for people with diabetes: >>> nanoparticles that contained human diabetes-related molecules were able to >>> restore normal blood sugar levels in a humanized mouse model of diabetes. >>> >>> According to Teodora Staeva, Ph.D., JDRF Program Director of Immune >>> Therapies, a key finding from the Alberta study is that only the immune >>> cells specifically focused on aggressively destroying beta cells (or, >>> alternatively, regulating these cells) responded to the antigen-specific >>> nanoparticle vaccine. That means the treatment did not compromise the rest >>> of the immune system – a key consideration for the treatment to be safe and >>> effective in an otherwise healthy person with type 1 diabetes. >>> >>> "The potential that nanoparticle vaccine therapy holds in reversing the >>> immune attack without generally suppressing the immune system is >>> significant," said Dr. Staeva. "Dr. Santamaria's research has provided both >>> insight into pathways for developing new immunotherapies and >>> proof-of-concept of a specific therapy that exploits these pathways for >>> preventing and reversing type 1 diabetes." >>> >>> Dr. Santamaria noted that the study had implications for other autoimmune >>> diseases beyond type 1 diabetes. "If the paradigm on which this nanovaccine >>> is based holds true in other chronic autoimmune diseases, such as multiple >>> sclerosis, rheumatoid arthritis, and others, nanovaccines might find general >>> applicability in autoimmunity," he said. >>> >>> The nanoparticle vaccine technology used in the study has been licensed >>> by Parvus Therapeutics, Inc., a biotechnology company that is focused on the >>> development and commercialization of the technology for the potential >>> treatment of type 1 diabetes. >>> >>> The study, conducted at the University of Calgary in Alberta, Canada, >>> appears in the online edition of the scientific journal >>> *Immunity<http://www.cell.com/immunity/home> >>> *. >>> >>> >>> -- >>> Celebrating 10 years of bringing diversity to perversity! >>> Mahogany at: >>> http://groups.yahoo.com/group/mahogany_pleasures_of_darkness/ >>> >> >> >> >> -- >> "If all the world's a stage and we are merely players, who the bloody hell >> wrote the script?" -- Charles E Grant >> >> http://www.youtube.com/watch?v=fQUxw9aUVik >> >> >> > > > -- > Celebrating 10 years of bringing diversity to perversity! > Mahogany at: http://groups.yahoo.com/group/mahogany_pleasures_of_darkness/ > > -- "If all the world's a stage and we are merely players, who the bloody hell wrote the script?" -- Charles E Grant http://www.youtube.com/watch?v=fQUxw9aUVik
