Thank you so much for sharing this wonderful news. It will be very useful.
El viernes, 2 de junio de 2023, Matthew Fidler
escribió:
> The nlmixr2/rxode2 team is excited to announce a tool to help conversion
> of NONMEM to rxode2 or nlmixr2 fits with nonmem2rx and babelmixr2.
>
> With nonmem2rx
t; >
> > Executive Director
> >
> > Pharmacokinetics, Modeling, and Simulation (PKMS)
> >
> > Clinical Pharmacology and Exploratory Development (CPED)
> >
> > Astellas
> >
> > 1 Astellas Way
> >
> > Northbrook, IL 60062
> >
&g
Dear nmusers,
I'm working on the population PK of a therapeutic peptide candidate for
rheumatoid arthritis. Three dose levels of the peptide were administered as
a single subcutaneous injection.
We have some limitations, for instance, the dataset is very sparse and is
lacking in the information of
record so CL(TIME) is constant
>> between records, while in the DES block T (time) changes continuously,
>> thus implementing time dependence CL(T) exactly rather than
>> approximately. The rest is fine.
>> Thanks
>> Leonid
>>
>> On 7/22/2021 4:19 PM,
= CL2*EXP(-KDES*T)
> CL_TOTAL = CL2_TIME + CL1 ; total clearance
> ...
>
> Thanks
> Leonid
>
>
> On 7/22/2021 3:30 PM, Niurys.CS wrote:
>
>> Dear nmusers,
>> I'm working on the pharmacokinetics of an antiCD20 mAb; I suspect the
>> clearance of th
Dear nmusers,
I'm working on the pharmacokinetics of an antiCD20 mAb; I suspect the
clearance of this mAb should be time dependent as rituximab’s clearance do.
I tried to model this behavior but I’m not sure if the ODEs are correct.
Please can you help? I share part of the code.
$SUBROUTINE ADVAN
Do you know why the math book was sad?
> Answer: Because it had so many problems
>
>
> -Original Message-
> From: Leonid Gibiansky
> Sent: Thursday, April 29, 2021 11:42 AM
> To: Justin Wilkins ; Bill Denney <
> wden...@humanpredictions.com>; Bonate, Peter ;
> Niurys.CS
>
e
> washout time. During this time, concentrations drop approximately 2^5=32
> times. So one can simulate the desired dosing (single dose or steady
> state), find the time from Cmax to Cmax/32 and call it washout time (or
> time to Cmax/64 to be conservative)
>
> Thanks
> Leonid
>
>
Dear all
I need some help to assess the elimination half life of a monoclonal
antibody.
The model that describes the data is a QSS aproximation of TMDD with Rmax
constant. The model includes two binding process of mAb to its target: in
central and peripheral compartments.
Is there any specific equa
Dear Wenping and nlmixr team,
Thanks for sharing with us your work!!!
Hugs,
Niurys
27;t help, giving more info will help. (What tool are you using
> for bootstrap? What command line are you running? Can you share the model
> and a snippet of the data?)
>
> Thanks,
>
> Bill
>
> -Original Message-
> From: owner-nmus...@globomaxnm.com On Beh
Dear nmusers,
I have a big doubt. When I used the bootstrap to evaluate my model, I
had some bugs. In my code I use IGNORE statements based on FLAGS for
some outliers. I don't know if I remove these IGNORE statements, the
bootstrap will run well. Can you give me some suggestions???
Regards
rt of
> the code was not shown, and it depends on the assay (for QSS part of the
> model).
>
> Thanks
> Leonid
>
>
> On 4/23/2019 8:34 AM, Niurys.CS wrote:
>> Dear All,
>>
>> I'm working on the population pharmacokinetics of a mAb, in this stud
Dear All,
I'm working on the population pharmacokinetics of a mAb, in this study
4 dose levels (50, 100, 200 and 400 mg) were evaluated. I tested
different models, but none of them fit well; that's why I decided to
find for each dose level the best model. I found the two lower dose
levels fitted
Dear All,
I'm working on the population pharmacokinetics of a mAb, in this study
4 dose levels (50, 100, 200 and 400 mg) were evaluated. I tested
different models, but none of them fit well; that's why I decided to
find for each dose level the best model. I found the two lower dose
levels fitted
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