[ccp4bb] Postdoc position at the Institute of Cancer Research, London
Post Doctoral Training Fellow Section of Structural Biology, The Institute of Cancer Research The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organization with HEFCE RAE ratings of international excellence across all of its research programmes. In partnership with The Royal Marsden NHS Foundation Trust, we form the largest comprehensive cancer centre in Europe, dedicated to research that extends from epidemiology, genetics and molecular biology, through drug discovery and development, to cancer diagnosis and patient treatment. This makes us uniquely placed to work towards our vision that people may live their lives free from the fear of cancer as a life threatening disease. This Cancer Research UK Development Committee funded position will provide structural biology support for the hit-to-lead development of small molecule inhibitors of a protein kinase. The successful applicant will determine crystal structures of the kinase bound to small molecule inhibitors and contribute to the structure-based design of more potent, more specific inhibitors. The project will be carried out in the laboratory of Dr Richard Bayliss (Structural Biology), in collaboration with chemists at the Institute (Centre for Cancer Therapeutics), and the University of Newcastle. Applicants must hold a PhD, or be close to completing their PhD studies, in biochemistry, molecular biology or structural biology. An ability to independently determine X-ray crystal structures of proteins is essential. Experience in high-throughput crystallography for drug discovery would be considered an asset. The position is offered on a fixed term contract of up to two years in the first instance with a starting salary in the range £26,597 to £29,256 p.a. inclusive. Informal enquires may be made to Dr Richard Bayliss (Tel: +44 (0)20 7153 5557 / Email: [EMAIL PROTECTED]). Please DO NOT send your application to Dr Bayliss; CVs must be submitted in line with the instructions below. For further particulars and details of how to apply, please visit our website at www.icr.ac.uk. Alternatively you may call our 24 hour recruitment line on 020 7153 5475 quoting reference number C137. Closing date: 2 May 2008 The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
Re: [ccp4bb] Installing coot on MacOSX 10.5
An update, in case this is still a burning issue for anybody. The fink package maintainer for Ruby updated the package over the weekend. Coot now builds fine from scratch on 10.4.11. I haven't tested 10.5, but it should also be okay. On 17 Apr 2008, at 20:23, Paul Emsley wrote: The mind boggles as to why you'd need ruby to install Coot... Ruby is a dependency of SWIG (in Fink, at least). Chris -- Dr Chris Richardson - sysadmin, Structural Biology Section, icr.ac.uk The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
Re: [ccp4bb] pH-ing Jeffamine ED-2001
Hi Amit, Changing the pH of Jeffamine is not so easy . I would keep the pH of Jeffamine constant and rather change the pH of buffer. Anyway if Jeffamine concentration is too low as compare to the buffer you are using, it would not change the final pH much. This is what my experience with Jeffamine is. Cheers, Yogesh On Mon, Apr 21, 2008 at 9:20 AM, amit sharma [EMAIL PROTECTED] wrote: Dear CCP4ers, Apologies for a non-CCP4 query. I intend to set up an optimization grid around one of the crystallization conditions (containing Jeffamine ED-2001pH 7.0 and HEPES pH 7.0) by varying the buffer pH from 5.5 to 7.5. In such a case, is it recommmended that the pH of Jeffamine ED-2001(pH 7.0) also be changed to match the different buffer pHs(5.5-7.5)? Cheers, Amit -- Yogesh K. Gupta, Ph.D. Post Doctoral Fellow Molecular Physiology Biophysics Mount Sinai School of Medicine 1425, Madison Av. (East Bldg. 16-26) Box 1677, New York, NY 10029-6574 Tel:+1 212-659-8639 Fax:+1 212-849-2456 E-mail: [EMAIL PROTECTED] -
[ccp4bb] hydrodynamic radius from atomic coordinates
Dear colleagues, Does anyone know of a program to calculate hydrodynamic radius of a protein from atomic coordinates? Thanks. Mike Colaneri
[ccp4bb] Kay Diederichs and Novel_R source?
I would like to get a hold of the program Novel_R, the source code for which is supposed to be available on Kay Diederichs' web site. However, the links I have seem to be outdated. Does Diederichs have a new web site, and is the Novel_R source still available? The outdated link: http://strucbio.biologie.uni-konstanz.de/~kay Thanks, -- === With the single exception of Cornell, there is not a college in the United States where truth has ever been a welcome guest - R.G. Ingersoll === David J. Schuller modern man in a post-modern world MacCHESS, Cornell University [EMAIL PROTECTED]
Re: [ccp4bb] hydrodynamic radius from atomic coordinates
I guess Hydro fits your needs: http://www.biophysj.org/cgi/content/abstract/67/2/530 http://www.sciencedirect.com/science?_ob=MImg_imagekey=B6TFB-3V5N9WY-2W-M_cdi=5222_user=5674961_orig=search_coverDate=08%2F24%2F1998_sk=999259997view=cwchp=dGLbVlb-zSkWWmd5=89c6e850ab49c3ecac6c19ec00414525ie=/sdarticle.pdf and finally http://leonardo.fcu.um.es/macromol/programs/programs.htm HTH, --asn On Mon, Apr 21, 2008 at 7:43 PM, Michael Colaneri [EMAIL PROTECTED] wrote: Dear colleagues, Does anyone know of a program to calculate hydrodynamic radius of a protein from atomic coordinates? Thanks. Mike Colaneri -- [ ]s --alessandro
Re: [ccp4bb] Kay Diederichs and Novel_R source?
David J. Schuller wrote: I would like to get a hold of the program Novel_R, the source code for which is supposed to be available on Kay Diederichs' web site. However, the links I have seem to be outdated. Does Diederichs have a new web site, and is the Novel_R source still available? The outdated link: http://strucbio.biologie.uni-konstanz.de/~kay Thanks, Try here: http://strucbio.biologie.uni-konstanz.de/strucbio/index.php?article_id=53clang=0 Juergen -- Jürgen Bosch University of Washington Dept. of Biochemistry, K-426 1705 NE Pacific Street Seattle, WA 98195 Box 357742 Phone: +1-206-616-4510 FAX: +1-206-685-7002 Web: http://faculty.washington.edu/jbosch
[ccp4bb] density_modify.inp is not running in cns1.2 but runs in cns1.1
Hi All, I am trying to run density_modify.inp in cns 1.2. it stops
with the error enclosed below. But, it runs with cns 1.1 perfectly. I am using
the same two data files(e.g. p65_se_rdey.hkl.cv and combine.hkl). Does anyone
have experience like this? Any solution is well appreciated.
Regards...
Raja
ANOMalous=TRUE {ON}
Program version= 1.2 File version= 1.2
%XMAPASU-AUTOmem: increasing memory allocation to200
Minimum brick that covers asymmetric unit:
A= 0,...,64 B= 0,...,64 C= 0,...,25
Sum of 5287 elements = 5287.
SHOW: average of102400 elements= 0.
ANOMalous=TRUE {ON}
XMPST: average = 0. minimum = 0. maximum = 0.
XMPST: r.m.s. = 0. norm = 0.
XMHISTO: (default from map) RHOMIN and RHOMAX = 0. 0.
%XMHISTO-ERR: a complete flat map.
XMHISTO: (default from map) SLOT width = 0.00
%XMHISTO-ERR: the SLOT width is too small 0.0
XMHISTO: the number of slots MBINS=1 and width SLOT= 0.
%XDOTYPE-ERR: Variable/type mismatch:
do (masksol=1) (real(automap) = $cutoff)
^
%DO-ERR: Data type mismatch. Selection must be a logical expression.:
do (masksol=1) (real(automap) = $cutoff)
^
%SHOW error encountered: There were errors in DO expression.
(CNS is in mode: SET ABORT=NORMal END)
*
ABORT mode will terminate program execution.
*
Program will stop immediately.
Maximum dynamic memory allocation:18336916 bytes
Maximum dynamic memory overhead: 360 bytes
Program started at : 18:01:44 on 21-Apr-2008
Program stopped at : 18:01:46 on 21-Apr-2008
CPU time used : 1.9700 seconds
Total runtime : 0. seconds
Program compiled by David Gohara
Regards...
Raja
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