[ccp4bb] postdoctoral position in structural biology of the tubulin code

2022-06-15 Thread Antonina Roll-Mecak
A postdoctoral fellowship opportunity is available in the Cell Biology and
Biophysics Unit headed by Dr. Antonina Roll-Mecak to work on the tubulin
code using in vitro reconstitution and superresolution microscopy to
capture the dynamic behavior of cytoskeletal complexes coupled with
cryo-EM, single particle, and tomography to obtain structural information
in vitro and in cells. For more information please visit:
https://research.ninds.nih.gov/roll-mecak-lab*. * We are looking for Ph.D.
graduates with a strong record of accomplishments and expertise in
biochemistry and cell biology. Expertise with cryo-EM is not needed. We are
happy to teach!  The NIH has an outstanding cell and structural biology
community, and the lab has regular access to state-of-the-art resources
such as a Chameleon, Krios with K3 camera, Glacios, TIRF and lattice sheet
microscopes, as well as cryo-FIB SEM. Please send your CV, a one-page
research experience summary and contact information of three references to
anton...@nih.gov  Please write “Tubulin code fellowship” in the subject
header.



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[ccp4bb] Postdoctoral Position Available

2022-06-15 Thread Troy Johnson
Hi All, 
This post is to bring your attention to a postdoctoral position currently 
available in the Structural Chemistry group, part of the Institute for Applied 
Cancer Science (IACS) within the Therapeutics Discovery Division of MD Anderson 
Cancer Center. The highly collaborative teams within IACS are focused on 
discovering and developing the next generation of small-molecule therapeutics 
targeting unmet medical needs in oncology and neurodegeneration. 

This is a unique opportunity to learn how structural biology contributes to the 
development of novel therapeutics by participating in the drug discovery 
process as a team member. The postdoctoral researcher will have the opportunity 
to work in a project-driven environment with a multi-disciplinary team of 
scientists from several functional groups (eg. in vitro pharmacology, medicinal 
and computational chemistry) all within a highly respected academic and 
clinical setting.

We are seeking an individual with a background in structural biology, including 
protein expression and purification, protein crystallization, and X-ray 
crystallography structure determination. Experience with biophysical techniques 
to measure binding interactions (eg. ITC, SPR, MST), fragment based drug 
discovery and/or structure determination of membrane proteins is not required, 
but would be advantageous. We want a motivated individual to join us in our 
quest to discover, develop, and deliver more effective treatments to our 
patients.

Interested individuals should send an introductory email and CV to 
therapeut...@mdanderson.org

To apply visit the link below:
https://www.mdanderson.org/about-md-anderson/careers/open-trainee-positions.html
Applied Cancer Science - Req #: 600140-202204261644



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Re: [ccp4bb] X-ray crystallography defense questions

2022-06-15 Thread John R Helliwell
Dear Jessica,
The opening question from your external examiner I expect to be “Your 
studentship funder is interested in your training and competence in research 
methods, your university however, in deciding to award your degree, has to know 
what your contribution to knowledge is?” PhD theses require an abstract but 
what you need to answer that question is a shorter synopsis. A synopsis can be 
quite tricky to get right whilst being succinct.

I realise I have not answered your precise question, on Xray crystallography 
questions that may arise. So, on that point, the topical question seems to be 
“What is your view on being able to predict what you have found out by Xray 
crystallography?
 
Best wishes,
John
Emeritus Professor John R Helliwell DSc




> On 14 Jun 2022, at 16:58, Jessica Besaw  wrote:
> 
> 
> Hello CCP4!
> 
> I am preparing for my PhD defense on X-ray crystallography of membrane 
> proteins.
> 
> So my ask from you folks is: What X-ray crystallography questions would you 
> ask in a PhD defense? 
> 
> All questions - easy, tough, tricky - are welcome.
> 
> Thank you kindly,
> 
> Jessica Besaw
> 
> 
> 
> 
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