[ccp4bb] Post-doctoral positions available to study signaling complexes

[Peti,Wolfgang]

Postdoctoral positions for the study of signaling complexes



The Peti Laboratory at the University of Connecticut Health Center has an 
immediate opening for two postdoctoral candidates to study eukaryotic signaling 
enzymes, with a focus on the function of phosphatases that form large signaling 
complexes and phosphatase drug/inhibitor development. All studies combine 
cryo-EM/NMR or X-ray crystallography with biochemical and in situ experiments, 
allowing postdocs to augment their training in those techniques that are new. 
Applicants with a strong background in biochemical techniques, and especially 
eukaryotic protein expression and protein crystallization or biomolecular NMR 
spectroscopy, are encouraged to apply.



The Peti laboratory (recent publications see: 
https://pubmed.ncbi.nlm.nih.gov/?term=peti+w=date=100) is housed in a 
newly renovated ~250,000 sq. ft. research laboratory in Farmington, CT. The 
laboratories are open-lab-space facilities and allow close interaction with the 
adjunct structural biology and molecular/cell biology groups at UConn Health. 
The Peti laboratory is equipped with all necessary infrastructure to produce 
(E. coli, mammalian), purify and analyze protein and protein complexes (ITC, 
SPR etc.) and crystallization robotics for crystal production (Art Robbins 
Gryphon LCP nano-liter crystallization robot; Art Robbins CrysCam) as well as 
all needed equipment for cryo-EM sample preparation and data evaluation.



UCHC facilities include a Bruker Venture D8 system (IμS Diamond source) with a 
Photon III M14 detector and cold stream is available for crystal screening and 
data collection for in-house data collection, synchrotron access at NSLS-II, 
SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz NMR 
spectrometers). A new cryo-EM instrument will be installed in spring 2023 that 
will allow for rapid screening of auto-grid/clipped samples of sample 
conditions. Access to Krios instruments for data collection is readily 
available.



UCHC has a welcoming, collaborative and vibrant environment for structural, 
biochemical and translational research. Farmington, CT, is located in New 
England between Boston (90 min.) and New York City (90 min). Starting date, 
salary and project details are negotiable.



Please e-mail a Cover Letter and CV to Wolfgang Peti (p...@uchc.edu)



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[ccp4bb] postdoctoral position

[Phoebe A. Rice]

[Text  Description automatically generated]
Postdoctoral Position in the Rice Lab at the University of Chicago.

Mechanism, Engineering, and Structural Biology of Large Serine Integrases
A postdoctoral position is available immediately the laboratory of Dr. Phoebe 
Rice.


Large serine integrases (LSIs; derived from lysogenic phages) mediate precise 
site-specific DNA recombination (integration, excision, or inversion), leaving 
not a single nick in the DNA backbone.  Control of LSI directionality is 
uniquely simple.  The integrase itself catalyzes phage insertion, but not the 
reverse (excision) reaction. Excision requires a 2nd protein called a 
recombination directionality factor (RDF), that binds its cognate integrase and 
alters its conformation in an unknown manner that somehow inhibits integration 
and activates excision. LSI-RDF pairs can catalyze the insertion of large 
payloads without relying on host DNA repair (unlike CRISPR-Cas-based systems) 
and can scarlessly and controllably reverse those insertions (unlike any other 
system).


This project seeks to (1) understand, through cryo electron microscopy and 
biochemistry, how an RDF interacts with its cognate integrase to control the 
reaction direction; (2) through bioinformatics and protein engineering, 
eliminate the current bottleneck in identifying cognate RDFs for individual 
LSIs and (3) enhance the usefulness of RDFs by engineering new control 
mechanisms into them.  The project is funded by a new large, collaborative NSF 
+ UKRI/BBSRC award to the Rice (https://voices.uchicago.edu/phoebericelab/) and 
Olorunniji (Olorunniji 
lab)
 labs.



Successful applicants will have a Ph.D. or MD/PhD in the broadly defined fields 
of Biochemistry, Biophysics, and/or Molecular Biology.  Experience with the 
tools of structural biology and / or nucleic acid biochemistry is preferred.  
Applicants should be eager to learn new skills and systems, and should have 
effective communication, teamworking and problem-solving skills.



The postdoctoral fellow will be part of the vibrant local structural biology, 
protein engineering and microbiology communities, with access to our 
state-of-the-art electron microscopy facilities 
https://voices.uchicago.edu/advancedem/.  Mentorship will be tailored to the 
fellow’s goals and can include, for instance, participation in the University’s 
MyChoice career development program and guided mentorship of diverse 
undergraduate students.


To apply, email Dr. Rice at pr...@uchicago.edu and include a cover letter 
explaining relevant work experience and interest in this position, a CV and the 
contact information of 2-3 references.

Compensation in the Biological Sciences Division follows the NIH NRSA Stipend 
scale. Additional information on benefits and being a postdoc in the University 
of Chicago Biological Sciences Division can be found at 
https://bsdpostdoc.uchicago.edu/.

The University of Chicago is an Affirmative Action/Equal 
Opportunity/Disabled/Veterans Employer and does not discriminate on the basis 
of race, color, religion, sex, sexual orientation, gender identity, national or 
ethnic origin, age, status as an individual with a disability, protected 
veteran status, genetic information, or other protected classes under the law. 
For additional information please see the University's Notice of 
Nondiscrimination at: 
www.uchicago.edu/non-discrimination 
. Job seekers in need of a reasonable accommodation to complete the application 
process should call +1 773-834-6693 or email hmcgu...@bsd.uchicago.edu with 
their request.





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[ccp4bb] CBMS Lecture Series - November 16

[Stojanoff, Vivian]

You are cordially invited to join  the Center for Biomolecular Structure 
Lecture Series ………..





David P. Harper

Center for Renewable Carbon, The University of Tennessee



WEDNESDAY, November 16, 13:30 (EST)



"Engineered Carbon Materials Derived from Lignin for Energy Storage"



Register in advance for this meeting:

  https://bnl.zoomgov.com/meeting/register/vJIsf-GuqjkvHvUBsoAXXwWoAjcRqXR8BPA​​



  Time conversion Link: 
https://www.worldtimebuddy.com/



Abstract:

Lignin’s carbon-dense aromatic structure and abundance promise to replace 
carbon derived from fossil or mined sources. However, lignin’s heterogeneous, 
amorphous structure and difficulty isolating it in high purity from woody 
feedstocks make predicting processing performance and carbon structure 
difficult. Strategies for processing multiple lignin feedstocks from 
organosolv, kraft, and other fractionation technologies into carbon materials, 
along with the relative advantages/disadvantages of carbon from traditional 
sources. Further, the influence of processing and lignin sources on the 
development of carbon structure will be addressed. Preliminary models for 
lignin-based carbon materials will be presented along with potential 
implications for their use in energy storage and beyond.



Bio: Dr. Harper earned a BA in Physics from West Virginia University and a 
Ph.D. in Civil Engineering from Washington State University in 2003, focusing 
on structural composite materials. He was a Post-Doctoral Fellow at the USDA 
Forest Products Laboratory in Madison, WI. Dr. Harper joined the Department of 
Forestry, Wildlife, and Fisheries in 2004 at the University of Tennessee 
located within UT’s Institute of Agriculture and is a joint faculty member in 
UT’s Department of Materials Science and Engineering. Since then, his research 
has focused on making new, high-value materials from renewable, plant-based 
sources. Dr. Harper can be contacted by email: dharp...@utk.edu .




==



Vivian Stojanoff, PhD

Education, Training, Outreach

User Program

p 1(631) 344 8375

e lifesciences@bnl.gov

w https://www.bnl.gov/ps/lifesciences/



Address:

Center for Biomolecular Structure

National Synchrotron Light Source II

Building 745

Brookhaven National Laboratory

Upton NY 11973



Supporting Grants: CBMS is supported by NIH-NIGMS #P30GM133893, and by the 
DOE-BER #KP1605010. Any work performed at NSLS-II is supported by DOE-BES  
under contract # DE-SC0012704.








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[ccp4bb] PostDoc position at the SGC, University of Toronto

[Levon Halabelian]

A PostDoc position is immediately available at the SGC, University of
Toronto. Details can be found in the following link:
https://www.thesgc.org/careers/toronto/postdoctoral-fellows-structural-biology

APPLICATIONS SHOULD BE SENT TO: [hrsgctoro...@thesgc.org] with the subject
line “SGC Postdoc in Structural Biology”.

Regards,
Levon



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[ccp4bb] Postdoc opening - DNA integrases

[Laura Spagnolo]

Hi,

Just a reminder of the upcoming deadline (Nov 26th) to apply for a postdoctoral 
position  in my group, to work on the structure/function study of serine 
integrases.

now with working link :-)

https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.display_form
https://www.jobs.ac.uk/job/CUM478/research-associate

Best wishes,

Laura






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[ccp4bb] Postdoctoral fellowship in experimental structural biology at Uppsala University

[Julia Griese]

Dear all,

I have an opening for a postdoctoral fellow in my group at the Department of 
Cell and Molecular Biology, Uppsala University, Sweden.

The project aims to study the DNA recognition mechanism of a metal-responsive 
transcription factor. The successful candidate should have experience in 
macromolecular X-ray crystallography, single-particle cryo-EM or NMR 
spectroscopy, as well as protein production and purification. Experience of 
complementary techniques in biochemistry and biophysics would be a benefit.

For more information about the position please see the attached document. 
Please note that suitable candidates must have obtained their PhD no earlier 
than 6 years ago and be able to start at the latest in March 2023. Please also 
note that this position is funded by a stipend.

Informal inquiries and applications should be sent to Julia Griese, 
julia.gri...@icm.uu.se, with subject header 
“Postdoc in Structural Biology”, no later than November 30, 2022.

Best regards,

Julia


--
Dr. Julia Griese
Assistant Professor, Docent
Department of Cell and Molecular Biology
Uppsala University
BMC, Box 596
SE-75124 Uppsala
Sweden

email: julia.gri...@icm.uu.se
phone: +46-(0)18-471 4982
http://www.icm.uu.se/structural-biology/griese-lab/








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Postdoc in Structural Biology.pdf
Description: Postdoc in Structural Biology.pdf