[ccp4bb] PhD studentship at the University of Konstanz

[Olga Mayans]

*PhD studentship at the University of Konstanz*
 
We have a vacancy for a PhD student to join our laboratory at the Department of 
Biology, University of Konstanz, Germany. 

Our laboratory studies the molecular mechanisms underpinning the stress 
response, adaptation and disease process of striated muscle. The focus of the 
available PhD project is on identifying and characterizing protein complexes 
that mediate the communication of the contractile sarcomere with other cellular 
organelles, in particular the nucleus, thereby regulating the gene expression 
programme and adaptive metabolism of the myofibril in function of mechanical 
activity. Mechanistic hypotheses are to be developed and tested at the 
molecular level. We apply an integrative approach to structural biology that 
combines a rich variety of biochemical, biophysical, computational and 
structural methodologies, with emphasis on X-ray crystallography. 

*Qualifications*
Applicants should hold (or be in the process of obtaining) a Master's degree in 
biochemistry or related discipline, and be interested in learning both 
laboratory-based and computational methods as applicable to the study of 
biomolecules. A strong motivation to understand and discover the molecular 
mechanisms that enable function in living cells is required. Preliminary 
experience in cloning and recombinant protein production is expected. Good 
command of written and spoken English, the ability to work in a team, and good 
communication and organizational skills are required. 

*Application* 
Applications should contain the following documents in PDF format: 
1. Applicant's CV
2. Copies of original degree transcripts displaying marks obtained
2. A statement of motivation for pursuing PhD studies in molecular sciences 
3. Contact details of two referees
 
Informal enquiries and application materials should be submitted by email to: 
olga.may...@uni-konstanz.de

The position is fully-funded. The starting date is flexible, but a prompt start 
is desirable. 


Prof. Olga Mayans
Biophysics and Structural Biology
Department of Biology
Universität Konstanz
D-78457 Konstanz, 
Germany 




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[ccp4bb] Protein Sciences Job opportunity in Boston MA

[Yanfeng Zhou]

Dear all,

We are looking for a protein chemist / structural biologist to join our
protein sciences team.  Please check the link below, if you or you know
candidates who are looking for opportunities in protein engineering with
leading edge tools and protein sciences with high throughput capabilities.

https://www.linkedin.com/jobs/view/3454279480

*Senior to Principal Scientist, Protein Sciences*

ABio-X is a biotech incubator that incubates companies at the convergence
of disruptive technologies and innovative science, bringing transformative
medicines and solutions to the global market. Backed by CBC group, ABio-X
will have wholly-owned subsidiaries or make investments into certain
controlled companies, which will each have its own product portfolio and
operations managed by a separate leadership team.

ABio-X (NewCo) is a young startup built under Abio-X Holdings, Inc. (
https://www.abio-x.com) of CBC Group (http://www.cbridgecap.com), one of
the largest healthcare investment funds with $5B+ asset under management.
The company will leverage its proprietary library-based display and machine
learning platform to design and discover novel biotherapeutics for human
genetic diseases.

*Key Responsibilities*:

   - Design and implement protein engineering, production and molecular
   assessment experiments, including expression, purification, QC, and
   analytical characterization.
   - Design and optimize biophysical and biochemical studies of
   biotherapeutic molecules using high throughput and/or automated methods for
   candidate optimization and development.
   - Collaborate with other protein biochemists and biologists on major
   scientific breakthroughs
   - by designing experiments and optimizing strategies
   - Work closely with machine learning engineers and data scientists to
   advance ML/AI platform
   - Manage and direct CROs and direct reports.
   - Ensure effective and timely documentation in electronic laboratory
   notebooks.
   - Present/communicate research findings with cross-functional colleagues
   internally and at scientific meetings/conferences.
   - Stay scientifically current and contribute to the implementation of
   new technology and instrumentation.

*Qualifications*:

· PhD in structural biology, chemistry, biology, biochemistry, biomedical
engineering, or related field

· 5-10 years hands on industrial experience in protein construct design,
protein expression in mammalian cells and purification with AKTA, protein
QC (aSEC-HPLC), and biochemical biophysical characterizations (SPR, BLI,
DSF, CE-SDS, cIEF, DLS, MALS, mass spec, etc).

· Experience with automation and/or library based screening is a plus

· Solid experience with protein sequence/structure analysis and
characterization of sequence-structure-function relationship.

· Strong collaborative, organizational, and presentation skills

· Ability to direct Research Associates, Technicians and CROs

· Ability to document, maintain, and share an organized account of lab work
and results

MLAB Biosciences *is an Equal Opportunity employer and does not
discriminate against an applicant or employee because of race, creed,
color, religion, sex, national origin, ancestry, age, sexual orientation,
physical or mental disability, or veteran status.*


The duties listed in this job description are intended only as
illustrations of the various types of work that may be performed. The
omission of specific statements of duties does not exclude them from the
position if the work is similar, related, or a logical assignment to the
position.

Featured benefits


   - Medical insurance
   - Vision insurance
   - Dental insurance
   - 401(k)
   - Paid maternity leave
   - Paid paternity leave
   - Disability insurance



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Re: [ccp4bb] 3d stereo on windows 10/11

[mesters@biochem]

Active stereo support is slowly dying and the hardware will fail in the end 
(sorry to say)…. 

One possible alternative is a passive stereo PluraView 
 , which is expensive 
 but compatible with software such as YASARA, 
ChimeraX, PyMOL, Maestro, SYBYL-X, etc.

Regards

J.

> Am 10.02.2023 um 16:34 schrieb Krishnan Raman :
> 
> What is the best current hardware setup for 3d stereo on windows OS.
> Nividia does not support 3d vision anymore.
> Iam still hanging onto to the old system with p5000 Quadro cards. Would like 
> to know what  other alternatives are available?
> Regards
> Krish
>  
> 
> 
> 
> CONFIDENTIALITY NOTICE 
> 
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> attachment is strictly prohibited. If you have received this email in error, 
> please reply to the sender so that BioCryst Pharmaceuticals, Inc. can take 
> corrective measures and then permanently delete this email and any 
> attachment, including any printed copies. Thank you.
> 
> 
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> 



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Re: [ccp4bb] 3d stereo on windows 10/11

[Wim Burmeister]

Hello, 
you won't find anything better than the old system with the p5000 quadro cards. 
Just keep a linux computer running Debian 10 or Ubuntu 20 using the xfce 
desktop and hope that the hardware doesn't fail for the next few years. 
Best regards 
Wim 


De: "Krishnan Raman"  
À: "CCP4BB"  
Envoyé: Vendredi 10 Février 2023 16:34:05 
Objet: [ccp4bb] 3d stereo on windows 10/11 



What is the best current hardware setup for 3d stereo on windows OS. 

Nividia does not support 3d vision anymore. 

Iam still hanging onto to the old system with p5000 Quadro cards. Would like to 
know what other alternatives are available? 

Regards 

Krish 












CONFIDENTIALITY NOTICE 

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please reply to the sender so that BioCryst Pharmaceuticals, Inc. can take 
corrective measures and then permanently delete this email and any attachment, 
including any printed copies. Thank you. 




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-- 
Wim Burmeister 
Professor 
Institut de Biologie Structurale (IBS) CIBB 
71 avenue des Martyrs / CS 20192 
38044 Grenoble Cedex 9, FRANCE 
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 | website ] 




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[ccp4bb] Call for Serial Crystallography proposals at Diamond I24 as part of iNEXT Discovery funded access

[Owen, Robin (DLSLtd,RAL,LSCI)]

Dear all,



I would like to let you know that we are accepting new applications for serial 
beamtime at I24, Diamond, for access through the 
iNEXT-Discovery project.



This access route provides funded access to Diamond for EU users. Existing 
users do not need to reapply but should contact I24 staff for details on how 
they apply for iNEXT-Discovery funding.



The deadline for proposals in the current submission period is Sunday 5th March.



I24 can offer both extruder 
and fixed target serial synchrotron crystallography (SSX), with the majority of 
our experiments making use of fixed targets. We can offer both static and 
dynamic experiments with a range of excitation techniques, from laser light 
using a pharos laser system to substrate driven using acoustic droplet 
delivery. We are able to assist with sample preparation and optimisation if you 
currently have small numbers of single crystals and/or are new to serial 
crystallography.



For further information about serial crystallography at I24 please see the link 
below

https://www.diamond.ac.uk/Instruments/Mx/I24/I24-serial.html



For how to apply please see

https://www.diamond.ac.uk/Users/Support-for-European-Access-to-Life-Sciences/How-to-apply0.html



If you would like any further information or have questions, please contact 
myself or another member of beamline 
staff.



All the best,

Robin




Dr Robin Owen
Principal Beamline Scientist
I24, Microfocus Macromolecular Crystallography
Diamond Light Source, UK
Tel: +44 1235 778522
http://www.diamond.ac.uk/Beamlines/Mx/I24.html


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[ccp4bb] 3d stereo on windows 10/11

[Krishnan Raman]

What is the best current hardware setup for 3d stereo on windows OS.
Nividia does not support 3d vision anymore.
Iam still hanging onto to the old system with p5000 Quadro cards. Would like to 
know what  other alternatives are available?
Regards
Krish


CONFIDENTIALITY NOTICE

This email, including any attachments, may contain confidential or legally 
privileged information that is intended only for the individual or entity to 
whom it is addressed. If you are not the intended recipient, please be advised 
that any dissemination, distribution or copying of this email and any 
attachment is strictly prohibited. If you have received this email in error, 
please reply to the sender so that BioCryst Pharmaceuticals, Inc. can take 
corrective measures and then permanently delete this email and any attachment, 
including any printed copies. Thank you.



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