Re: [ccp4bb] About Staraniso

[Pavel Afonine]

Dear All,

What follows below is not very specific to the particular program
(STAIRSANISO) nor the original questions, but nonetheless, I believe it is
relevant.

In the past, performing any adjustments to the diffraction data intended
for solving and refining atomic models was more or less considered taboo.
When cryo-EM emerged as a competitor to x-ray crystallography, the paradigm
began to shift. In cryo-EM, manipulations applied to the data (the map) are
a standard practice. The map can be boxed, filtered (sharpened, blurred,
etc.), modified (e.g., setting something outside the molecular region), and
so forth; you name it. One might wonder why the same isn't done to x-ray
data. Historical analogies include truncating data beyond 6-8Å resolution
to avoid dealing with the bulk solvent or default sharpening (a feature
available in X-plor for some time, then removed for obvious reasons,
AFAIK), choosing resolution limits (PAIRREF), and anisotropic data
massaging by the UCLA server as a more recent example. STAIRSANISO is the
leader in doing things along these lines as of today.

Indeed, why not if this is helpful to solve the structure? However, it's
important that the deposition clearly contains and annotates at least the
following:

- the original unmanipulated data;
- modified data (by whatever method or program);
- accessible information about the data that was used to obtain the final
deposited atomic model.

Note *accessible* above as this is the key for what follows below.

Let's consider this example: https://files.rcsb.org/download/6R72-sf.cif ,
which is representative of the class of problems I'm trying to convey here.

The file has everything, kudos to the authors: The original data, the
manipulated data and a whole lot more.

Are these data accessible?

YES, if you download the file, open it in your favorite text editor, and
carefully scroll and read through its 76,566 lines and use your best guess
to infer what are the original data arrays, what are the modified data
arrays and so on.

NO, absolutely NO, if you parse data files in PDB automatically with a
script, and attempt to extract particular data (eg., original unmanipulated
data). And this is what I find problematic, especially given 215+k entries
in PDB as of today.

Hope someone does something about it!

All the best!
Pavel



On Tue, Feb 13, 2024 at 4:57 PM Arpita Goswami  wrote:

> Dear all,
>
> Good day. Thank you all for the very extensive discussions. Both on- and
> off-list discussions were very helpful.
>
> Thank you and a very happy Valentine's day to all..
>
> Best regards,
> Arpita
>
>
> On Wed, Feb 14, 2024, 01:25 Kay Diederichs 
> wrote:
>
>> Dear readers of CCP4BB,
>>
>> for various reasons I don't feel inclined to reply to this.
>>
>> I'm really sorry,
>> Kay
>>
>> On Tue, 13 Feb 2024 15:25:03 +, Gerard Bricogne <
>> g...@globalphasing.com> wrote:
>>
>> >Dear Kay,
>> >
>> ...
>>
>> 
>>
>> To unsubscribe from the CCP4BB list, click the following link:
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>
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Re: [ccp4bb] Combating disinformation in science and other areas

[Daniel M. Himmel, Ph. D.]

Dear all,


That’s a very nice idea to have an app to combat misinformation that can
undermine the integrity of science and foster mistrust of scientific
inquiry.  But to launch such an app raises the obvious question:


Who is to be the arbiter of what is true and what is “misinformation”?


The way to uphold the integrity of science is with a free exchange of
ideas, not an app or document that decides which publication or which
interpretation of the data is real science and which is misinformation.


Thanks go to Bryan Lepore for pointing out that the work of Herbert Marcuse
(a strong advocate of a brand of Marxism once popular in Germany) led to
much violence in the USA.  Violent revolutions are how a great deal of
science has been lost during the last several thousand years of human
history, which is why we’re first determining atomic and near-atomic
resolution structures in the 20th and 21st centuries, not eons ago.


So, my humble request:  Can we stick to crystallography and allied fields
of structure determination on this e-mail list, and not digress into
divisive politics, please?


Respectfully submitted,

Daniel



Daniel M. Himmel, Ph. D.

Principal, Himmel Sci Med Com, LLC

E-mail:  danielmhim...@gmail.com

URL   :  https://himmelscimedcom.com



On Wed, Feb 14, 2024 at 7:52 AM Bryan Lepore  wrote:

> The idea of "Global Sustainability" can be found in the documents for the
> noted projects, so the United Nations "Sustainable Development Goals"
> appear to be worth reviewing as background - even though it appears the UN
> or UNESCO (below) is irrelevant to them :
>
> “Transformation is the red thread running through all the Sustainable
> Development Goals, the United Nations’ agenda for responding to global
> challenges facing humanity and the planet. Setting our world on a more
> sustainable course requires radical shifts in current development
> paradigms that are exacerbating inequalities and imperilling [sic] our
> common future. This transition is dependent on new knowledge, research and
> competences that only higher education institutions are in a position to
> provide, rooted in their historic role of service to society.”
>
> [...]
>
> “In 1964, inspiring the 1968-student revolt a couple of years later,
> Herbert Marcuse wrote a key text against “one dimensional man”, urging
> universities and campuses around the world to become places that resisted
> reductionism. ”
>
>
> Source:
>
>
> Parr, et. al.
>
>
> “Knowledge-driven actions: transforming higher education for global
> sustainability”
>
>
> 2022
> UNESCO
> https://doi.org/10.54675/YBTV1653
>
> --
>
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>



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Re: [ccp4bb] Truncate / ctruncate / moments of E etc.

[Eleanor Dodson]

That pxmaths document was put together by Maria Turkenburg, with a bit of
input from me long long ago, but then the theory hasn't changed much in
that time.
My old reference was Srinvasen  & Parthasarathy
>From crystallography in India..
Influential books by him and his associates (R. Srinivasan, S.
Parthasarathy) in 1970 and 1976 on methods of solving the phase problem and
crystallographic statistics, are also noteworthy.

On Wed, 14 Feb 2024 at 15:49, Winter, Graeme (DLSLtd,RAL,LSCI) <
6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:

> Thanks Ian, that is much more what I was looking for!
>
> I knew I had seen something like this a long time ago
>
> All the best Graeme
>
> On 14 Feb 2024, at 15:36, Ian Tickle  wrote:
>
> You don't often get email from ianj...@gmail.com. Learn why this is
> important 
>
> This has graphs: https://www.ccp4.ac.uk/html/pxmaths/bmg10.html .
>
> -- Ian
>
>
> On Wed, Feb 14, 2024 at 3:25 PM Winter, Graeme (DLSLtd,RAL,LSCI) <
> 6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
>
>> Absolutely! However
>>
>> "(ie. not mathematics-first)”
>>
>> I was thinking of something with more pictures and graphs in ;-)
>>
>> I had already sent that newsletter but felt it may be a bit heavy going
>> as a first introduction
>>
>> All the best Graeme
>>
>> On 14 Feb 2024, at 15:17, David Waterman  wrote:
>>
>> Norman Stein's article at the back of this newsletter is the one I like!
>> https://legacy.ccp4.ac.uk/newsletters/newsletter47/newsletter47.pdf
>>
>> -- David
>>
>>
>> On Wed, 14 Feb 2024 at 15:14, Winter, Graeme (DLSLtd,RAL,LSCI) <
>> 6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
>>
>>> Good afternoon all,
>>>
>>> Chatting to someone and wanted to provide some pointers on how to
>>> interpret the moments of E from truncate or ctruncate, and realised that I
>>> don't have any good *references*​ for this to hand i.e. what I am
>>> looking for and why, and my google search didn't come up with much that was
>>> useful
>>>
>>> Those of us who have a few orbits under out belts picked up a lot of
>>> this from osmosis but if you are trying to explain to someone new it's a
>>> bit more tricky
>>>
>>> What have I missed? Where would you point people today to understand
>>> e.g. Wilson stats and suchlike, from a user perspective (ie. not
>>> mathematics-first)
>>>
>>> Thanks in advance for any pointers
>>>
>>> Graeme
>>>
>>>
>>> --
>>>
>>> This e-mail and any attachments may contain confidential, copyright and
>>> or privileged material, and are for the use of the intended addressee only.
>>> If you are not the intended addressee or an authorised recipient of the
>>> addressee please notify us of receipt by returning the e-mail and do not
>>> use, copy, retain, distribute or disclose the information in or attached to
>>> the e-mail.
>>> Any opinions expressed within this e-mail are those of the individual
>>> and not necessarily of Diamond Light Source Ltd.
>>> Diamond Light Source Ltd. cannot guarantee that this e-mail or any
>>> attachments are free from viruses and we cannot accept liability for any
>>> damage which you may sustain as a result of software viruses which may be
>>> transmitted in or with the message.
>>> Diamond Light Source Limited (company no. 4375679). Registered in
>>> England and Wales with its registered office at Diamond House, Harwell
>>> Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
>>>
>>>
>>> --
>>>
>>> To unsubscribe from the CCP4BB list, click the following link:
>>> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>>>
>>
>> --
>>
>> To unsubscribe from the CCP4BB list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>>
>>
>>
>>
>> --
>>
>> This e-mail and any attachments may contain confidential, copyright and
>> or privileged material, and are for the use of the intended addressee only.
>> If you are not the intended addressee or an authorised recipient of the
>> addressee please notify us of receipt by returning the e-mail and do not
>> use, copy, retain, distribute or disclose the information in or attached to
>> the e-mail.
>> Any opinions expressed within this e-mail are those of the individual and
>> not necessarily of Diamond Light Source Ltd.
>> Diamond Light Source Ltd. cannot guarantee that this e-mail or any
>> attachments are free from viruses and we cannot accept liability for any
>> damage which you may sustain as a result of software viruses which may be
>> transmitted in or with the message.
>> Diamond Light Source Limited (company no. 4375679). Registered in England
>> and Wales with its registered office at Diamond House, Harwell Science and
>> Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
>>
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Re: [ccp4bb] Truncate / ctruncate / moments of E etc.

[Winter, Graeme (DLSLtd,RAL,LSCI)]

Thanks Ian, that is much more what I was looking for!

I knew I had seen something like this a long time ago

All the best Graeme

On 14 Feb 2024, at 15:36, Ian Tickle 
mailto:ianj...@gmail.com>> wrote:

You don't often get email from ianj...@gmail.com. 
Learn why this is important

This has graphs: https://www.ccp4.ac.uk/html/pxmaths/bmg10.html .

-- Ian


On Wed, Feb 14, 2024 at 3:25 PM Winter, Graeme (DLSLtd,RAL,LSCI) 
<6a19cead4548-dmarc-requ...@jiscmail.ac.uk>
 wrote:
Absolutely! However

"(ie. not mathematics-first)”

I was thinking of something with more pictures and graphs in ;-)

I had already sent that newsletter but felt it may be a bit heavy going as a 
first introduction

All the best Graeme

On 14 Feb 2024, at 15:17, David Waterman 
mailto:dgwater...@gmail.com>> wrote:

Norman Stein's article at the back of this newsletter is the one I like!
https://legacy.ccp4.ac.uk/newsletters/newsletter47/newsletter47.pdf

-- David


On Wed, 14 Feb 2024 at 15:14, Winter, Graeme (DLSLtd,RAL,LSCI) 
<6a19cead4548-dmarc-requ...@jiscmail.ac.uk>
 wrote:
Good afternoon all,

Chatting to someone and wanted to provide some pointers on how to interpret the 
moments of E from truncate or ctruncate, and realised that I don't have any 
good references​ for this to hand i.e. what I am looking for and why, and my 
google search didn't come up with much that was useful

Those of us who have a few orbits under out belts picked up a lot of this from 
osmosis but if you are trying to explain to someone new it's a bit more tricky

What have I missed? Where would you point people today to understand e.g. 
Wilson stats and suchlike, from a user perspective (ie. not mathematics-first)

Thanks in advance for any pointers

Graeme


--

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Re: [ccp4bb] Truncate / ctruncate / moments of E etc.

[Ian Tickle]

This has graphs: https://www.ccp4.ac.uk/html/pxmaths/bmg10.html .

-- Ian


On Wed, Feb 14, 2024 at 3:25 PM Winter, Graeme (DLSLtd,RAL,LSCI) <
6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:

> Absolutely! However
>
> "(ie. not mathematics-first)”
>
> I was thinking of something with more pictures and graphs in ;-)
>
> I had already sent that newsletter but felt it may be a bit heavy going as
> a first introduction
>
> All the best Graeme
>
> On 14 Feb 2024, at 15:17, David Waterman  wrote:
>
> Norman Stein's article at the back of this newsletter is the one I like!
> https://legacy.ccp4.ac.uk/newsletters/newsletter47/newsletter47.pdf
>
> -- David
>
>
> On Wed, 14 Feb 2024 at 15:14, Winter, Graeme (DLSLtd,RAL,LSCI) <
> 6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
>
>> Good afternoon all,
>>
>> Chatting to someone and wanted to provide some pointers on how to
>> interpret the moments of E from truncate or ctruncate, and realised that I
>> don't have any good *references*​ for this to hand i.e. what I am
>> looking for and why, and my google search didn't come up with much that was
>> useful
>>
>> Those of us who have a few orbits under out belts picked up a lot of this
>> from osmosis but if you are trying to explain to someone new it's a bit
>> more tricky
>>
>> What have I missed? Where would you point people today to understand e.g.
>> Wilson stats and suchlike, from a user perspective (ie. not
>> mathematics-first)
>>
>> Thanks in advance for any pointers
>>
>> Graeme
>>
>>
>> --
>>
>> This e-mail and any attachments may contain confidential, copyright and
>> or privileged material, and are for the use of the intended addressee only.
>> If you are not the intended addressee or an authorised recipient of the
>> addressee please notify us of receipt by returning the e-mail and do not
>> use, copy, retain, distribute or disclose the information in or attached to
>> the e-mail.
>> Any opinions expressed within this e-mail are those of the individual and
>> not necessarily of Diamond Light Source Ltd.
>> Diamond Light Source Ltd. cannot guarantee that this e-mail or any
>> attachments are free from viruses and we cannot accept liability for any
>> damage which you may sustain as a result of software viruses which may be
>> transmitted in or with the message.
>> Diamond Light Source Limited (company no. 4375679). Registered in England
>> and Wales with its registered office at Diamond House, Harwell Science and
>> Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
>>
>>
>> --
>>
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>
>
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Re: [ccp4bb] Truncate / ctruncate / moments of E etc.

[Winter, Graeme (DLSLtd,RAL,LSCI)]

Absolutely! However

"(ie. not mathematics-first)”

I was thinking of something with more pictures and graphs in ;-)

I had already sent that newsletter but felt it may be a bit heavy going as a 
first introduction

All the best Graeme

On 14 Feb 2024, at 15:17, David Waterman 
mailto:dgwater...@gmail.com>> wrote:

Norman Stein's article at the back of this newsletter is the one I like!
https://legacy.ccp4.ac.uk/newsletters/newsletter47/newsletter47.pdf

-- David


On Wed, 14 Feb 2024 at 15:14, Winter, Graeme (DLSLtd,RAL,LSCI) 
<6a19cead4548-dmarc-requ...@jiscmail.ac.uk>
 wrote:
Good afternoon all,

Chatting to someone and wanted to provide some pointers on how to interpret the 
moments of E from truncate or ctruncate, and realised that I don't have any 
good references​ for this to hand i.e. what I am looking for and why, and my 
google search didn't come up with much that was useful

Those of us who have a few orbits under out belts picked up a lot of this from 
osmosis but if you are trying to explain to someone new it's a bit more tricky

What have I missed? Where would you point people today to understand e.g. 
Wilson stats and suchlike, from a user perspective (ie. not mathematics-first)

Thanks in advance for any pointers

Graeme


--

This e-mail and any attachments may contain confidential, copyright and or 
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please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.
Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd.
Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.
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Re: [ccp4bb] Truncate / ctruncate / moments of E etc.

[David Waterman]

Norman Stein's article at the back of this newsletter is the one I like!
https://legacy.ccp4.ac.uk/newsletters/newsletter47/newsletter47.pdf

-- David


On Wed, 14 Feb 2024 at 15:14, Winter, Graeme (DLSLtd,RAL,LSCI) <
6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:

> Good afternoon all,
>
> Chatting to someone and wanted to provide some pointers on how to
> interpret the moments of E from truncate or ctruncate, and realised that I
> don't have any good *references*​ for this to hand i.e. what I am looking
> for and why, and my google search didn't come up with much that was useful
>
> Those of us who have a few orbits under out belts picked up a lot of this
> from osmosis but if you are trying to explain to someone new it's a bit
> more tricky
>
> What have I missed? Where would you point people today to understand e.g.
> Wilson stats and suchlike, from a user perspective (ie. not
> mathematics-first)
>
> Thanks in advance for any pointers
>
> Graeme
>
>
>
> --
>
> This e-mail and any attachments may contain confidential, copyright and or
> privileged material, and are for the use of the intended addressee only. If
> you are not the intended addressee or an authorised recipient of the
> addressee please notify us of receipt by returning the e-mail and do not
> use, copy, retain, distribute or disclose the information in or attached to
> the e-mail.
> Any opinions expressed within this e-mail are those of the individual and
> not necessarily of Diamond Light Source Ltd.
> Diamond Light Source Ltd. cannot guarantee that this e-mail or any
> attachments are free from viruses and we cannot accept liability for any
> damage which you may sustain as a result of software viruses which may be
> transmitted in or with the message.
> Diamond Light Source Limited (company no. 4375679). Registered in England
> and Wales with its registered office at Diamond House, Harwell Science and
> Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
>
>
> --
>
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[ccp4bb] Truncate / ctruncate / moments of E etc.

[Winter, Graeme (DLSLtd,RAL,LSCI)]

Good afternoon all,

Chatting to someone and wanted to provide some pointers on how to interpret the 
moments of E from truncate or ctruncate, and realised that I don't have any 
good references​ for this to hand i.e. what I am looking for and why, and my 
google search didn't come up with much that was useful

Those of us who have a few orbits under out belts picked up a lot of this from 
osmosis but if you are trying to explain to someone new it's a bit more tricky

What have I missed? Where would you point people today to understand e.g. 
Wilson stats and suchlike, from a user perspective (ie. not mathematics-first)

Thanks in advance for any pointers

Graeme

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[ccp4bb] EMBO practical course (8th-12th July, 2024) on time-resolved serial macromolecular crystallography (TR-SX) at Grenoble, France

[Shibom Basu]

Dear CCP4,

We are organizing an EMBO practical course dedicated to "Time-resolved 
macromolecular serial crystallography" at the EPN campus, Grenoble, 
France, from *8*_*th – 12th July, 2024*_. The course aims to train next 
generation researchers in the field of TR-SX with hands-on training from 
micro-crystallization, TR-SX data collection, processing to difference 
electron density map. We have a diverse and excellent list of 
speakers/trainers from the field.


Please take a look at the course webpage: 
https://www.embl.org/about/info/course-and-conference-office/events/ser24-01/


Advanced PhD students and postdocs are highly encouraged to apply and we 
will select 20 participants based on motivational letters/CV.


Application deadline: *15th April, 2024.
*

The course will offer plenty of time for discussion and opportunities 
for interactions from all career levels. Distinct events are 
incorporated to help participants for network and further their 
opportunities.


Best,

shibom

--
Shibom Basu, PhD.
Staff Scientist
European Molecular Biology Laboratory (EMBL)
71 avenue des Martyrs, CS 90181,
38042 Grenoble Cedex 9
France
Ph: +33-(0)-4 76 20 78 75



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[ccp4bb] Research Fellow in Biochemistry and Biophysics of Chaperone Function in Leeds

[Ville Uski]

-- Forwarded message -
From: Helen McAllister 
Date: Mon, 12 Feb 2024 at 17:13
Subject: [CCP4] Please could you advertise a post for us? FBSAS1073
To: c...@listserv.stfc.ac.uk 


Dear Sirs,



Please could you possibly advertise this post for us?



FBSAS1073 Research Fellow in Biochemistry and Biophysics of Chaperone
Function - Jobs at the University of Leeds




*Location: *

Leeds - Main Campus

*Faculty/Service: *

Faculty of Biological Sciences

*School/Institute: *

School of Molecular & Cellular Biology / Astbury Centre for Structural
Molecular Biology

*Category: *

Research

*Grade: *

Grade 7

*Salary: *

£37,099 to £44,263 p.a.

Due to funding limitations it is unlikely an appointment will be made above
£40,521

*Working Time: *

100% FTE - We are open to discussing flexible working arrangements

*Post Type: *

Full Time

*Contract Type: *

Fixed Term (available for 39 months from 1st April 2024, subject to start
date.)

*Release Date: *

Thursday 08 February 2024

*Closing Date: *

Sunday 03 March 2024

*Interview Date: *

To be confirmed

*Reference: *

FBSAS1073

*Downloads: *

Candidate Brief





Very many thanks for any help you can give.



Best wishes



*Helen*



Helen McAllister (Mrs), h.mcallis...@leeds.ac.uk

PA to Professor Sheena Radford, OBE, FRS, FMedSci

School of Cellular and Molecular Biology, Faculty of Biological Sciences

The University of Leeds, Leeds LS2 9JT

Working at home 4 days, and usually on campus on Fridays



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[ccp4bb] Mprocovid.com

[Duangrudee Tanramluk]

Happy Valentine's Day from Wi. 

My fullname "Duangrudee" means "a heart". I did my research on the main 
protease of SAR-CoV-2 which has a heart shape.

Our server http://mprocovid.com shown below use AI to help Covid-19 Drug Design 
based on active site boundary and frequently occurring atoms obtained from 
hundreds of SARS-CoV-2 Main Proteases' crystal structure.
See details in our paper:

https://www.nature.com/articles/s41598-023-34305-6

Best wishes, 
Duangrudee



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Re: [ccp4bb] Combating disinformation in science and other areas

[Bryan Lepore]

The idea of "Global Sustainability" can be found in the documents for the noted 
projects, so the United Nations "Sustainable Development Goals" appear to be 
worth reviewing as background - even though it appears the UN or UNESCO (below) 
is irrelevant to them :

“Transformation is the red thread running through all the Sustainable 
Development Goals, the United Nations’ agenda for responding to global 
challenges facing humanity and the planet. Setting our world on a more 
sustainable course requires radical shifts in current development paradigms 
that are exacerbating inequalities and imperilling [sic] our common future. 
This transition is dependent on new knowledge, research and competences that 
only higher education institutions are in a position to provide, rooted in 
their historic role of service to society.”
[...]
“In 1964, inspiring the 1968-student revolt a couple of years later, Herbert 
Marcuse wrote a key text against “one dimensional man”, urging universities and 
campuses around the world to become places that resisted reductionism. ”

Source:

Parr, et. al.

“Knowledge-driven actions: transforming higher education for global 
sustainability”

2022
UNESCO
https://doi.org/10.54675/YBTV1653


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Re: [ccp4bb] Combating disinformation in science and other areas

[John R Helliwell]

Dear Focco,Thankyou for drawing attention to this important domain, and I will look at your initiative with interest.Dear Colleagues on CCP4bb,I (virtually) attended the recent, excellent, USA National Academy of Sciences, Engineering and Medicine+Nobel Foundation Symposium entitled Truth, Trust and Hope details of which are here https://www.nationalacademies.org/our-work/nobel-prize-summit-2023-truth-trust-and-hope including recordings. It is a general interest level event, not crystallography per se, but is something we can take a useful interest in I think.Greetings,JohnEmeritus Professor John R Helliwell DScOn 13 Feb 2024, at 23:16, Focco van den Akker  wrote:Dear all,

 

As fellow
scientists specializing in structural biology, it's disheartening to witness a
decline in society's trust in science; perhaps many of you have come across the
remarkable book "The Deadly Rise of Anti-science: A Scientist's
Warning" by Dr. Peter Hotez. To help restore this trust, we co-founded a non-profit
and launched an educational app. If you are concerned as well, please read on
(the app even touches on structural biology):

 

As you know,
scientists and other fact-finding professions like journalism currently face
significant challenges. Our crucial work as reputable sources and the
scientific consensus we build can be readily undermined by misinformation and
conspiracy theories.

 

There is
probably no bigger problem in today’s world than the battle between facts and
mis- and disinformation, a conflict that not only fuels other large global
struggles such as vaccine hesitancy and climate change denial but also leads to
societal division and its consequential challenges. These dynamics collectively
contribute to heightened stress and suffering, both on individual and global
scales.

 

It's unlikely
that any of the world's biggest challenges can be solved as long as people
remain so easily swayed by misinformation and disinformation. To address this
pressing issue, we co-founded the non-profit organization Knowledge Advances
Inc., dedicated to educating individuals on navigating the complex ecosystem of
information and misinformation. We assert that information of higher
reliability is a basic human need, akin to water, food, and shelter.

 

To initiate our
efforts, we recently launched an app called Advance: Life training. The
app employs a comprehensive, active learning approach through quizzes to teach
users how to identify sources of higher reliability, discern information of
greater credibility, and understand biases.

 

For additional
details and to download the free Advance: Life Training app, please
visit our website: https://knowledgeadvances.org/

 

If our approach
and app resonate with you, we kindly ask you to support us by rating our
application on the app stores and sharing this information with your friends
and colleagues.

 

Please feel
free to contact us for further information or feedback.

 

Best regards,

 

Focco

 

Focco van den
Akker, Ph.D.

President,
Knowledge Advances Inc.

Associate
Professor, Dept. Biochemistry, Case Western Reserve University

Email:
focco.vandenak...@knowledgeadvances.org

https://knowledgeadvances.org/

https://case.edu/medicine/biochemistry/faculty/focco-van-den-akker


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