[ccp4bb] Fully funded PhD position in Structural biology/Cryo-EM/AMR available at University of Leicester, UK

[abhinav kv]

Dear all,

A fully funded PhD position is available within my lab (
https://www.akv-lab.com/) at the Department of Molecular and Cell Biology
(MCB) and Leicester Institute of Structural and Chemical Biology (LISCB),
University of Leicester, UK to carry out structural studies on large
macromolecular machines that undertake horizontal gene transfer (HGT) in
bacteria. This project has important implications on global efforts to
fight infections caused by persistent pathogens and combating
antimicrobial-resistance (AMR).



This interdisciplinary project offers the opportunity to work in a vibrant
interdisciplinary research environment and access to world-class research
facilities for structural biology and cryo-electron microscopy (cryo-EM).
It welcomes candidates passionate about structural biology, protein
structure-function, host-pathogen interactions, molecular microbiology, and
infectious diseases. The project provides the opportunity to engage in
interdisciplinary research, combining membrane-protein biochemistry,
molecular biology, biophysics, genomics, cross-linking mass-spectrometry,
bioinformatics, live-cell imaging, and structural biology (X-ray
crystallography and cryo-EM) to understand the molecular mechanisms
associated with these processes. Access to LISCB's cutting-edge microscopy
infrastructure, including the state-of-the-art Titan Krios 300 keV
microscope and a supportive, collaborative work environment enhances this
opportunity.



*Position details:*

This position is funded for 3.5 years and is available from September 2024. The
last date of application is 29th April 2024.



*How to apply: *

More details on the project can be found here:
https://le.ac.uk/study/research-degrees/funded-opportunities/liscb-mcb--akv



To know more, visit our website: https://www.akv-lab.com/.

We are based at the Department of Molecular and Cell Biology
(MCB)/Leicester Institute of Structural and Chemical Biology, University of
Leicester, UK:
https://le.ac.uk/research/institutes/structural-chemical-biology



For informal enquiries, contact Dr. Abhinav KV, MCB/LISCB, University of
Leicester: ak...@leicester.ac.uk.


Regards,

Dr. Abhinav Koyamangalath Vadakkepat,

Lecturer and Group Leader,

MCB/LISCB,

University of Leicester, UK.



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Re: [ccp4bb] twinning or not?

[Phil Evans]

You can get apparent twinning if neighbouring spots are overlapped in any direction, and that may be worse with a home source with larger beam divergence. In that case a weak reflection may be corrupted by a neighbouring strong reflection, leading to intensity statistics characteristic of twinningPhilSent from my iPadOn 25 Mar 2024, at 19:24, Thomas, Leonard M.  wrote:CAUTION: This email originated from outside of the LMB:
.-owner-ccp...@jiscmail.ac.uk-.
Do not click links or open attachments unless you recognize the sender and know the content is safe.If you think this is a phishing email, please forward it to phish...@mrc-lmb.cam.ac.uk
--





Hello,


I have run into a very odd situation.  Upon collection and data processing on a crystal on my home source all pointers seemed to show twinning.  Was not surprised since previous crystals under different but related conditions have showed significant
 twinning though the cell dimensions were different but not the resulting apparent space group.  


Now the odd thing, I sent the crystal to the synchrotron figuring I might be able to get some data that might help figure out what is going on.  Upon processing of the synchrotron data, SSRL 9-2, magically no twining was detected.  A couple of
 other crystals of the same compound though not from the same exact condition showed the twinning.  I processed the data using HKL, which I primarily on my home source data and XDS with similar results.  


In summary, the exact same crystal shows twinning on Cu home source and no twinning at all at the synchrotron.


Any ideas would be welcomed.


Len






Leonard Thomas, Ph.D.
Biomolecular Structure Core, Director
Oklahoma COBRE in Structural Biology
Price
 Family Foundation Institute of Structural Biology
University
 of Oklahoma
Department
 of Chemistry and Biochemistry
101
 Stephenson Parkway
Norman,
 OK 73019-5251
Office:
 (405)325-1126
lmtho...@ou.edu
http://www.ou.edu/structuralbiology/cobre-core-facilities/mcl









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[ccp4bb] Up to two postdoctoral positions in integrative structural biology study of signaling complexes

[Page,Rebecca]

*** Attention: This is an external email. Use caution responding, opening 
attachments or clicking on links. ***

Postdoctoral positions in integrative structural biology study of signaling 
complexes


The Page Laboratory at the University of Connecticut Health Center has an 
immediate opening for up to two postdoctoral candidates to study eukaryotic 
signaling enzymes, with a focus on the function of phosphatases that form large 
signaling complexes and phosphatase drug/inhibitor development (recent 
publications include Nature 
[https://www.nature.com/articles/s41586-023-06870-3], Nature communications 
[https://www.nature.com/articles/s41467-023-37372-5]).


All studies combine cryo-EM, NMR and/or X-ray crystallography with biochemical 
and cellular experiments, allowing postdocs to augment their training in those 
techniques that are new. Applicants with strong backgrounds in biochemical 
techniques, and especially eukaryotic protein expression and protein 
crystallization or cryoEM, are encouraged to apply.


The Page laboratory is housed in a newly renovated ~250,000 sq. ft. research 
laboratory in Farmington, CT. The laboratories are open-lab-space facilities 
and allow close interaction with the adjunct structural biology and 
molecular/cell biology groups at UConn Health. The Page laboratory is equipped 
with all necessary infrastructure to produce (E. coli, mammalian, insect), 
purify and analyze protein and protein complexes (ITC, SPR etc.) and 
crystallization robotics for crystal production (Art Robbins Gryphon LCP 
nano-liter crystallization robot; Art Robbins CrysCam) as well as all needed 
equipment for cryo-EM sample preparation and data evaluation.


UCHC facilities include a Bruker Venture D8 system (IμS Diamond source) with a 
Photon III M14 detector and cold stream is available for crystal screening and 
data collection for in-house data collection, synchrotron access at NSLS-II, 
SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz NMR 
spectrometers). Cryo-EM instrument includes a TFS Vitrobot IV and a TFS 
Tundra/Falcon C) that allows for rapid screening of auto-grid/clipped samples 
of sample conditions. Access to Krios instruments for data collection is 
readily available.


UCHC has a welcoming, collaborative and vibrant environment for structural, 
biochemical and translational research. Farmington, CT, is located in New 
England between Boston (90 min.) and New York City (90 min). Laboratory alumni 
are successful, including alums that have their own academic faculty positions, 
are directors/chief scientists in pharma and startups, gone into public policy, 
among others.


Starting date, salary and project details are very competitive and negotiable.


Please e-mail a Cover Letter and CV to Rebecca Page (rp...@uchc.edu)

Rebecca Page, PhD
Professor
UConn Health | Cell Biology (L5080)
263 Farmington Avenue | Farmington, CT 06030
rp...@uchc.edu

Page laboratory website



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Re: [ccp4bb] twinning or not?

[Kay Diederichs]

Hi Len,

a possible theory: your crystals may be macroscopically twinned, i.e. 
consisting of single crystals attached to each other in the way that the twin 
operation describes.
At your home source, you employ a rather big beam that hits more than one 
single crystal. So the data appear twinned. At the synchrotron however, the 
beam is way smaller, and may hit only a single crystal. Hence, untwinned data.

HTH, Kay

On Mon, 25 Mar 2024 19:22:54 +, Thomas, Leonard M.  wrote:

>Hello,
>
>I have run into a very odd situation.  Upon collection and data processing on 
>a crystal on my home source all pointers seemed to show twinning.  Was not 
>surprised since previous crystals under different but related conditions have 
>showed significant twinning though the cell dimensions were different but not 
>the resulting apparent space group.
>
>Now the odd thing, I sent the crystal to the synchrotron figuring I might be 
>able to get some data that might help figure out what is going on.  Upon 
>processing of the synchrotron data, SSRL 9-2, magically no twining was 
>detected.  A couple of other crystals of the same compound though not from the 
>same exact condition showed the twinning.  I processed the data using HKL, 
>which I primarily on my home source data and XDS with similar results.
>
>In summary, the exact same crystal shows twinning on Cu home source and no 
>twinning at all at the synchrotron.
>
>Any ideas would be welcomed.
>
>Len
>
>Leonard Thomas, Ph.D.
>Biomolecular Structure Core, Director
>Oklahoma COBRE in Structural Biology
>Price Family Foundation Institute of Structural Biology
>University of Oklahoma
>Department of Chemistry and Biochemistry
>101 Stephenson Parkway
>Norman, OK 73019-5251
>Office: (405)325-1126
>lmtho...@ou.edu
>http://www.ou.edu/structuralbiology/cobre-core-facilities/mcl
>
>
>
>
>To unsubscribe from the CCP4BB list, click the following link:
>https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>
>This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing 
>list hosted by www.jiscmail.ac.uk, terms & conditions are available at 
>https://www.jiscmail.ac.uk/policyandsecurity/
>



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[ccp4bb] twinning or not?

[Thomas, Leonard M.]

Hello,

I have run into a very odd situation.  Upon collection and data processing on a 
crystal on my home source all pointers seemed to show twinning.  Was not 
surprised since previous crystals under different but related conditions have 
showed significant twinning though the cell dimensions were different but not 
the resulting apparent space group.

Now the odd thing, I sent the crystal to the synchrotron figuring I might be 
able to get some data that might help figure out what is going on.  Upon 
processing of the synchrotron data, SSRL 9-2, magically no twining was 
detected.  A couple of other crystals of the same compound though not from the 
same exact condition showed the twinning.  I processed the data using HKL, 
which I primarily on my home source data and XDS with similar results.

In summary, the exact same crystal shows twinning on Cu home source and no 
twinning at all at the synchrotron.

Any ideas would be welcomed.

Len

Leonard Thomas, Ph.D.
Biomolecular Structure Core, Director
Oklahoma COBRE in Structural Biology
Price Family Foundation Institute of Structural Biology
University of Oklahoma
Department of Chemistry and Biochemistry
101 Stephenson Parkway
Norman, OK 73019-5251
Office: (405)325-1126
lmtho...@ou.edu
http://www.ou.edu/structuralbiology/cobre-core-facilities/mcl




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[ccp4bb] Postdoc in the group of Aneika Leney at U. Birmingham

[Klaus Futterer]

Please, see the postdoctoral position advertised below in the broad context of 
structural biology research using mass spectrometry.

For informal inquiries contact my colleague Dr Aneika Leney (a.le...@bham.ac.uk)

Klaus

===
Klaus Fütterer, PhD
Reader in Structural Biology


School of Biosciences
LES CollegeEmail: 
k.futte...@bham.ac.uk
University of Birmingham Phone: +44 - 121 - 414 5895
Birmingham, B15 2TT, UK(voice mail messages will 
forward to my email inbox)

My normal working hours are Mon - Fri 9.00 - 6.00 pm.
For my office hours, please contact me by email

How to pronounce my 
name

===

From: Aneika Leney (Biosciences) 
Sent: 18 March 2024 13:31

Hi all,

We are currently advertising a 3-year post-doc position. 
https://www.jobs.ac.uk/job/DGL324/research-fellow-in-structural-biology. I'm 
looking for either a structural biologist or a mass spectrometrist (or someone 
with both expertise). They would work on finding a new molecular switch to 
enhance photosynthetic control.

Thanks,

Aneika





Dr Aneika Leney
Associate Professor in Biomolecular Mass Spectrometry
School of Biosciences
College of Life and Environmental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT, UK





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[ccp4bb] 2024 ACA Meeting - Abstract and Travel Grants Deadline Friday 3/29/2024

[Sarah Bowman]

Hi everyone,
The 2024 Annual ACA Meeting will be in Denver, CO from July 7 - July 11, 2024!  
Program details https://www.acameeting24.com/sessionlist.

The abstract submission deadline is this Friday March 29, 2024!

There is a great lineup of sessions and abstracts are still being accepted – 
check out the list of sessions below.  To submit an abstract: 
https://www.acameeting24.com/callforabstracts.

There are also resources available for students and early-career structural 
scientists – travel award deadline is also Friday March 29, 2024!  Info: 
https://www.acameeting24.com/studentresources

Please join us in Denver this summer.

Cheers,
Sarah (on behalf of the ACA Meeting Committee)

Sunday 7/7/2024
Workshops

Monday 7/8/2024
1.1.1 Advances in In situ cryo-electron tomography
1.1.2 Provenance, Workflow & Responsibility for X-Rays, Neutrons and Electrons 
– Part 1
1.1.3 Utilizing In Situ & Operando Techniques To Elucidate Complex Systems
1.1.4 Structure Visualization
1.1.5 SAS In Biotherapeutics & Drug Development: SAXS/SANS/Hybrid Methods
1.2.1 New Sample Preparation Technology for Cryo-EM & Cryo-ET
1.2.2 Provenance, Workflow & Responsibility for X-Rays, Neutrons and Electrons 
– Part 2
1.2.3 Extreme Biophysical & Biochemical Environments
1.2.4 Home-Built Software & Hardware
1.2.5 Hot Structures

Tuesday 7/9/2024
2.1.1 General Interest - Part 1
2.1.2 Light Sources Through the Decades - Part 1
2.1.3 Structural Biology in Pharma/Biotech - Part 1
2.1.4 Algorithms & Computational Methods in CryoEM
2.1.5 Tips & Tricks for Modern Structural Methods
2.1.6 Mathematical, Theoretical & Computational Crystallography
2.2.1 General Interest - Part 2
2.2.2 Light Sources Through the Decades - Part 2
2.2.3 Structural Biology in Pharma/Biotech - Part 2
2.2.4 Symmetry and Emergent Orders in Quantum and Strongly Correlated Materials
2.2.5 Using Microed at Your Institution: How Microed & Cryo-EM Can Coexist
2.2.6 Growth of Metal Oxide Structure & Assembly of Nanomaterials
2.3.1 Career Odysseys

Wednesday 7/10/2024
3.1.1 Engaging Students with Crystallography
3.1.2 Structure of Nucleic Acids - Part 1: CryoEM
3.1.3 Recent Developments in Membrane Protein Structural Biology
3.1.4 Data Analysis Software & Applications
3.1.5 Structural Characterizations ff Emerging Energy Materials
3.1.6 Developments in Data Collection & Automation In Microed
3.2.1 Flexibility, Dynamics, And The Secret Lives Of Proteins
3.2.2 Structure of Nucleic Acids - Part 2: SAS/Hybrid Approaches
3.2.3 MicroED for Small Molecules
3.2.4 Serial Crystallography
3.2.5 A Hitchhiker’s Guide to Peer Review
3.2.6 Alternative Methods for Structure Determination
3.3.1 Would You Publish This?
3.3.2 DEI Session: #IAmRemarkable

Thursday 7/11/2024
4.1.1 Biological Structures from Artificial Intelligence
4.1.2 Totally Total Scattering
4.1.3 Macromolecular Microcrystal Electron Diffraction
4.1.4 Structural Biology of Metallobiomolecules
4.1.5 Latest Developments, Applications & Experiences Featuring Quantum 
Crystallography
4.1.6 Advances in SAS Instrumentation
4.2.1 AI in Modern Crystallography
4.2.2 Cool Structures
4.2.3 Hybrid, Multimodal & Ancillary Methods
4.2.4 Super-charging experiments using real-time analysis: crystallography in 
the high data rate age
4.2.5 Recent Advances in Fiber Diffraction
4.2.6 Biomolecular Dynamics & Frontiers in SAS

Sarah EJ Bowman PhD
Associate Investigator | Hauptman-Woodward Medical Research Institute
Director | National High-Throughput Crystallization Center
Associate Research Professor | University at Buffalo Department of Biochemistry

Member | US National Committee for Crystallography

p: +1 716 898 8623
e: sbowman at hwi.buffalo.edu

Research Webpage
Crystallization Center Webpage

Hauptman-Woodward Medical Research Institute
700 Ellicott Street | Buffalo, NY 14203



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[ccp4bb] Multiple Positions available UK

[Panne, Daniel (Prof.)]

Dear all,

We currently have several positions open at different levels! The project is 
part of an interdisciplinary, collaborative and international project involving 
groups in Imperial College London, the Netherlands Cancer Institute (NKI) 
Amsterdam, the University of Oxford, and the University of Leicester.

This project focuses on understanding molecular mechanisms that control the 
regulation of 3D genome organisation. The 3D genome organization refers to the 
spatial arrangement of chromatin within the nucleus, including the positioning 
of chromosomes, formation of chromatin loops, and interactions between 
regulatory elements such as promoters and enhancers. The dysregulation of 3D 
genome organization has been increasingly recognized as a significant factor in 
cancer development and progression. We aim to understand the molecular 
mechanisms that enable control of 3D genome organization. Understanding these 
control mechanisms will be essential for identifying novel therapeutic 
strategies.

We offer:

  *   Collaborative and supportive research environment
  *   State-of-the-art laboratory facilities
  *   Mentorship from experienced researchers and professors
  *   Access to a vibrant scientific community
  *   Opportunities for national and international collaborations


You will play a pivotal role in conducting experiments, analysing data, and 
interpreting results. You will engage in interdisciplinary research that 
combines structural biology, molecular biology, genomics, and bioinformatics to 
gain a holistic understanding of molecular mechanisms that enable control of 3D 
genome organisation.

1. Postdoc 
level:
 The initial closing date for applications is 8th April 2024, however 
applications will be reviewed and interviewed on an ongoing basis until this 
vacancy is filled.

2. Research Assistant 
level: The 
successful candidate should have a BSc, MSc or PhD Degree in a relevant field. 
The closing date is 18 Apr 2024

3. PhD 
Studentship:
 The closing date is Monday 29th April.


Should you have any questions, please do not hesitate to contact me.

Daniel Panne
Department of Molecular and Cell Biology
University of Leicester
Wellcome Trust Investigator







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