[ccp4bb] JOB IN SCIENTIFIC ILLUSTRATION AT THE MRC LABORATORY OF MOLECULAR BIOLOGY (LMB), CAMBRIDGE
JOB OPPORTUNITY FOR A SCIENTIFIC ILLUSTRATOR AND ANIMATOR AT THE MRC LABORATORY OF MOLECULAR BIOLOGY (LMB), CAMBRIDGE, UKWe are looking for a Scientific Illustrator and Animator to join the VisLab team at the LMB. The role holder will create innovative and intriguing 2D and 3D still and animated graphics for visualisation and communication of the LMB’s exceptional science and research, preferably using Blender. If you have experience or know anybody who has, and are interested to pursue this field and join the team, please contact Shraddha Nayak sna...@mrc-lmb.cam.ac.uk for more details. The goal of the VisLab team is to help visualise and communicate LMB's compelling science On behalf of Shraddha Nayak (sna...@mrc-lmb.cam.ac.uk)Please see attached for more details. To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 LMBVisLab_SciIllustratorAnimator.pdf Description: Adobe PDF document __Dr. David BarfordStructural Studies DivisionMRC Laboratory of Molecular BiologyFrancis Crick AvenueCambridge CB2 0QH, UK.e.mail: dbarf...@mrc-lmb.cam.ac.ukTel. +44 (0)1223 26707507919 927824 (M) To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
[ccp4bb] reminder: MRC-LMB Group Leader position closing date 27th Oct
Dear colleagues, Just a reminder that our position for a Programme Leader at the MRC Laboratory of Molecular Biology (Cambridge, UK) will be closing on Oct 27th. In brief, we are seeking to appoint an outstanding scientist with game-changing ideas for the development and application of novel methods in molecular/cellular structural biology that will lead to solving long-term fundamental questions. More info can be found here: https://www.nature.com/naturecareers/job/programme-leaderprogramme-leader-track-mrc-laboratory-of-molecular-biology-704913 <https://www.nature.com/naturecareers/job/programme-leaderprogramme-leader-track-mrc-laboratory-of-molecular-biology-704913> David ___ Dr. David Barford Structural Studies Division MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH, UK. e.mail: dbarf...@mrc-lmb.cam.ac.uk Tel. +44 (0)1223 267075 To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
[ccp4bb] group leader position at MRC-LMB
Dear colleagues, The MRC Laboratory of Molecular Biology wishes to recruit a new Programme Leader/Programme Leader Track to the Division of Structural Studies. We are seeking to appoint an outstanding scientist with game-changing ideas for the development and application of novel methods in molecular/cellular structural biology that will lead to solving long-term fundamental questions. Potential areas of interest include, but are not limited to: 1. Sample preparation and/or experimental approaches in electron microscopy, including cryo-electron tomography and labelling. 2. Single-molecule and other biophysical techniques to understand macromolecular dynamics. 3. Computational approaches to provide quantitative understanding of macromolecular structure and dynamics. The MRC-LMB is one of the birthplaces of molecular and structural biology and is extremely well equipped for the research envisioned, including crystallography, electron microscopy and NMR, as well as light microscopy and biophysics, supported by electronic and mechanical workshops. We welcome applicants from all scientific disciplines. The appointment will be made at either Programme Leader or Programme Leader-track level, depending on achievements and experience. For informal enquiries please contact David Barford (dbarf...@mrc-lmb.cam.ac.uk <mailto:dbarf...@mrc-lmb.cam.ac.uk>), Lori Passmore (passm...@mrc-lmb.cam.ac.uk <mailto:passm...@mrc-lmb.cam.ac.uk>) or Sjors Scheres (sche...@mrc-lmb.cam.ac.uk <mailto:sche...@mrc-lmb.cam.ac.uk>). https://www.nature.com/naturecareers/job/programme-leaderprogramme-leader-track-mrc-laboratory-of-molecular-biology-704913 <https://www.nature.com/naturecareers/job/programme-leaderprogramme-leader-track-mrc-laboratory-of-molecular-biology-704913> Closing date: 27th Oct, 2019 (not the originally advertised 4th Oct) _______ Dr. David Barford Structural Studies Division MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH, UK. e.mail: dbarf...@mrc-lmb.cam.ac.uk Tel. +44 (0)1223 267075 To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
[ccp4bb] Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge. Closing date 28th Nov
Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laboratory of Molecular Biology (LMB) seeks to appoint a Protein Crystallography Facility Manager. The LMB is one of the birthplaces of structural biology and remains at the forefront of methods development as protein crystallography is a critical technique for understanding the mechanisms of macromolecular complexes, one of the major goals of the LMB. The post-holder will provide support to researchers from all Divisions of the LMB in the collection of X-ray diffraction data using both synchrotrons and in-house X-ray facilities, will maintain and develop the in-house facilities, will provide expert advice and support during subsequent structure determinations, and will act as the coordinator for LMB's synchrotron access. It is expected that there will be the opportunity for collaboration on structural projects with research groups at the LMB. The successful applicant will have several years of post-doctoral experience in the field of protein crystallography including data collection at synchrotrons and all aspects of structure determination. Excellent communication and inter-personal skills are required because the post will involve interacting with a diverse range of scientists with different levels of expertise. Closing date for applications: 28th November 2018 For further details and information on how to apply please visit: Jobs.ac: https://www.jobs.ac.uk/job/BNU298/protein-crystallography-facility-manager-structural-studies <https://www.jobs.ac.uk/job/BNU298/protein-crystallography-facility-manager-structural-studies> Nature: https://www.nature.com/naturecareers/job?id=661643 <https://www.nature.com/naturecareers/job?id=661643> Informal enquires should be addressed to Dr. David Barford. E.mail: dbarf...@mrc-lmb.cam.ac.uk <mailto:dbarf...@mrc-lmb.cam.ac.uk> _______ Dr. David Barford Structural Studies Division MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH, UK. e.mail: dbarf...@mrc-lmb.cam.ac.uk Tel. +44 (0)1223 267075 To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
[ccp4bb] Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge, UK
Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laboratory of Molecular Biology (LMB) seeks to appoint a Protein Crystallography Facility Manager. The LMB is one of the birthplaces of structural biology and remains at the forefront of methods development as protein crystallography is a critical technique for understanding the mechanisms of macromolecular complexes, one of the major goals of the LMB. The post-holder will provide support to researchers from all Divisions of the LMB in the collection of X-ray diffraction data using both synchrotrons and in-house X-ray facilities, will maintain and develop the in-house facilities, will provide expert advice and support during subsequent structure determinations, and will act as the coordinator for LMB's synchrotron access. It is expected that there will be the opportunity for collaboration on structural projects with research groups at the LMB. The successful applicant will have several years of post-doctoral experience in the field of protein crystallography including data collection at synchrotrons and all aspects of structure determination. Excellent communication and inter-personal skills are required because the post will involve interacting with a diverse range of scientists with different levels of expertise. Closing date for applications: 28th November 2018 For further details and information on how to apply please visit: Jobs.ac: https://www.jobs.ac.uk/job/BNU298/protein-crystallography-facility-manager-structural-studies <https://www.jobs.ac.uk/job/BNU298/protein-crystallography-facility-manager-structural-studies> Nature: https://www.nature.com/naturecareers/job?id=661643 <https://www.nature.com/naturecareers/job?id=661643> Informal enquires should be addressed to Dr. David Barford. E.mail: dbarf...@mrc-lmb.cam.ac.uk <mailto:dbarf...@mrc-lmb.cam.ac.uk> To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
[ccp4bb] Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, closing date: 11th June 2018
Dear colleagues, The closing date for applications for the position of Protein Crystallography Facility Manager at the LMB is Monday 11th June. Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laboratory of Molecular Biology (LMB) seeks to appoint a Protein Crystallography Facility Manager. The LMB is one of the birthplaces of structural biology and remains at the forefront of methods development as protein crystallography is a critical technique for understanding the mechanisms of macromolecular complexes, one of the major goals of the LMB. The post-holder will provide support to researchers from all Divisions of the LMB in the collection of X-ray diffraction data using both synchrotrons and in-house X-ray facilities, will maintain and develop the in-house facilities, will provide expert advice and support during subsequent structure determinations, and will act as the coordinator for LMB's synchrotron access. It is expected that there will be the opportunity for collaboration on structural projects with research groups at the LMB. The successful applicant will have several years of post-doctoral experience in the field of protein crystallography including data collection at synchrotrons and all aspects of structure determination. Excellent communication and inter-personal skills are required because the post will involve interacting with a diverse range of scientists with different levels of expertise. Closing date for applications: 11th June 2018 For further details and information on how to apply please visit: https://mrc.tal.net/vx/appcentre-ext/candidate/post/1707/en-GB <https://mrc.tal.net/vx/appcentre-ext/candidate/post/1707/en-GB> Informal enquires should be addressed to Dr. David Barford. E.mail: dbarf...@mrc-lmb.cam.ac.uk <mailto:dbarf...@mrc-lmb.cam.ac.uk> Dr. Jan Löwe. E.mail: j...@mrc-lmb.cam.ac.uk <mailto:j...@mrc-lmb.cam.ac.uk> To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
[ccp4bb] Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge, UK
Dear colleagues, Please see below an advert for the position of Protein Crystallography Facility Manager at the MRC Laboratory of Molecular Biology. Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laboratory of Molecular Biology (LMB) seeks to appoint a Protein Crystallography Facility Manager. The LMB is one of the birthplaces of structural biology and remains at the forefront of methods development as protein crystallography is a critical technique for understanding the mechanisms of macromolecular complexes, one of the major goals of the LMB. The post-holder will provide support to researchers from all Divisions of the LMB in the collection of X-ray diffraction data using both synchrotrons and in-house X-ray facilities, will maintain and develop the in-house facilities, will provide expert advice and support during subsequent structure determinations, and will act as the coordinator for LMB's synchrotron access. It is expected that there will be the opportunity for collaboration on structural projects with research groups at the LMB. The successful applicant will have several years of post-doctoral experience in the field of protein crystallography including data collection at synchrotrons and all aspects of structure determination. Excellent communication and inter-personal skills are required because the post will involve interacting with a diverse range of scientists with different levels of expertise. Closing date for applications: 11th June 2018 For further details and information on how to apply please visit: https://mrc.tal.net/vx/appcentre-ext/candidate/post/1707/en-GB <https://mrc.tal.net/vx/appcentre-ext/candidate/post/1707/en-GB> Informal enquires should be addressed to Dr. David Barford. E.mail: dbarf...@mrc-lmb.cam.ac.uk <mailto:dbarf...@mrc-lmb.cam.ac.uk> Dr. Jan Löwe. E.mail: j...@mrc-lmb.cam.ac.uk <mailto:j...@mrc-lmb.cam.ac.uk> _______ Dr. David Barford Structural Studies Division MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH, UK. e.mail: dbarf...@mrc-lmb.cam.ac.uk Tel. +44 (0)1223 267075
[ccp4bb] Post-doctoral position at the LMB, Cambridge, UK
MRC Laboratory of Molecular Biology, Cambridge, UK Post-doctoral Scientist Position We seek to appoint a postdoctoral researcher to the Division of Structural Studies to undertake protein crystallographic analysis of the anaphase promoting complex (APC/C) and its subunits. This is an Investigator Scientist position funded by Cancer Research UK for 3 years and is located at the MRC Laboratory of Molecular Biology in Cambridge, UK within the group of David Barford. The Investigator Scientist will join a team investigating the structure and mechanism of the anaphase promoting complex (APC/C), a large macro-molecular assembly that regulates progression through the cell cycle. The project will focus on crystal structure determination of the whole APC/C and APC/C subunits and sub-complexes. This project extends our existing 11 Å resolution structure determined using single particle electron microscopy and takes advantage of our recombinant over-expression system for reconstituting APC/C (da Fonseca et al., (2011) and Schreiber et al., (2011)). The project would suit a highly motivated and committed scientist interested in molecular mechanisms of the cell cycle, cancer biology and structural biology. The successful applicant will hold at least a PhD (or equivalent) in a biological/physical science. Experience with protein crystallography is essential and experience with protein crystallisation and purification would be an advantage. The post is available from 1st October 2013 (or earlier). The starting salary will be set within £26,282 to £31,686. However, the full salary range for a position of this type is from £26,282 - £37,040. Informal enquires may be made to David Barford (david.barf...@icr.ac.uk<mailto:david.barf...@icr.ac.uk>). The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
[ccp4bb] X-ray crystallography manager position - The Institute of Cancer Research
The Institute of Cancer Research (University of London) Section of Structural Biology, Chelsea, London X-RAY CRYSTALLOGRAPHY MANAGER The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organisation. In the 2008 Higher Education Funding Councils' Research Assessment Exercise, The ICR received the highest percentage of research assessed as four stars, world leading, in the areas of biological sciences and cancer studies. We came top of the Times Higher Education overall table of HEIs that submitted to more than one UoA - ranking it as the UK's leading academic research centre. Research in the Section of Structural Biology is aimed at understanding the structural basis for the function and regulation of proteins and complexes implicated in cancer. Our research programmes are complemented by close links with groups elsewhere in The Institute, and provide the mechanistic and structural framework for developing new therapeutics targeted at cancer. The Section is well equipped for structural biology with state of the art X-ray equipment, robotics and computational infrastructure. We seek to appoint an X-ray Crystallography Manager to facilitate the research programmes of the Section of Structural Biology and other groups within the Institute, particularly the Section of Cancer Therapeutics. The key roles of the post will be (i) to take direct responsibility for the overall crystallographic and crystallisation infrastructure of the Section, (ii) to coordinate and conduct crystallographic data collection experiments at synchrotron radiation sources, (iii) to assist PhD students and post-doctoral scientists to determine structures using X-ray crystallography, and (iv) contribute to the scientific output of the Section through protein crystal structure determination and analysis. The successful applicant will hold a PhD (or equivalent) in protein crystallography and have considerable post-doctoral experience. The position is non-timed limited, and the appointment will be at the Senior Scientific Officer level with a starting salary in the range £37,241 to £44,336 p.a. with a start date of 1st July or as soon as possible thereafter. Appointment will require clear evidence of contribution to published work. Informal enquires may be made to the Section Chairman, Professor David Barford (david.barf...@icr.ac.uk). Details of the Sections’ research activities can be found on http://www.icr.ac.uk/research/research_sections/structural_biology/index.shtml Please do not send your application direct to Professor Barford, CVs must be submitted in line with the instructions below. For further particulars and details of how to apply, please visit our website at www.icr.ac.uk. Alternatively you may call our 24 hour recruitment line on 020 7153 5475 quoting reference number C356. Closing date: 15th June 2010 __ Professor David Barford Section of Structural Biology Institute of Cancer Research Chester Beatty Laboratories 237 Fulham Road London, SW3 6JB United Kingdom Tel. +44 (0)20 7153 5420 FAX +44 (0)20 7153 5457 PA (Sonia Malkani) +44 (0)20 7153 5443 E. mail: david.barf...@icr.ac.uk http://www.icr.ac.uk/research/research_sections/structural_biology/teams/barford_team/index.shtml The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
[ccp4bb] Post doctoral position at the Institute of Cancer Research, London
Post Doctoral Training Fellow - David Barford's team - Section of Structural Biology - Institute of Cancer Research - London Applications are invited for a post-doctoral training fellow to join a team investigating the structure and mechanism of proteins that regulate the cell cycle and signal transduction processes implicated in cancer. The aim of this project is to apply X-ray crystallographic techniques to determine the structure and mechanism of RAS converting enzyme (RCE1), a novel intramembrane protease responsible for post-translational processing of the C-terminal CAAX motif of RAS and a range of other signalling proteins. This work will provide a framework for initiating high-throughput structure-based inhibitor design to develop novel anti-cancer therapies targeted at RAS signalling pathways. Based within Prof. David Barford’s group the project involves a combination of biochemical, structural and inhibitor design approaches. The project would suit a highly motivated and committed scientist interested in molecular mechanisms of signal transduction and cancer biology, membrane proteins and drug discovery. The successful applicant will hold a PhD in X-ray crystallography and have experience with molecular biology, protein expression, purification and crystallisation, preferably of membrane proteins. The position is offered on a fixed term contract available from Jan 2010 up to 30th Sep 2012 in the first instance with a starting salary in the range £29,695 to £34,353 p.a. according to experience. Informal enquires may be made to D. Barford (Tel:+44(0)20 7153 5420 / Email: david.barf...@icr.ac.uk). http://www.icr.ac.uk/research/research_profiles/2958.shtml Please Note - this email address is for enquiries only; CVs must be submitted in line with the instructions below. To apply, please send two copies of your CV and covering letter addressing where you meet the person specification (incl. the names and addresses of two referees) together with a completed Equal Opportunities Monitoring Form to the HR Office, The Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP quoting job Ref C259. Closing date for applications: 2 October 2009 http://www.icr.ac.uk/jobs/current_vacancies/13649.shtml The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
[ccp4bb] Symposium in Honour of Louise Johnson, September 2007
Announcement of a Symposium in honour of Professor Dame Louise Johnson, Oxford University, Sep 2nd to 5th 2007 Themes of the symposium will include protein structure, signal transduction, protein phosphorylation, the cell cycle, enzymatic mechanisms, synchrotron radiation, electron microscopy, drug design, and some historical recollections. Speakers include: Tom Blundell, Cambridge Iain Campbell, Oxford Philip Cohen, Dundee Elizabeth Duke, Diamond Light Source David Eisenberg, UCLA, Los Angeles Elspeth Garman, Oxford Eddy Fischer, Seattle Janos Hajdu, Stanford/Uppsala Richard Henderson, Cambridge Tim Hunt, CR-UK London Research Institute, Clare Hall Tony Hunter, Salk Institute, La Jolla Louise Johnson, Oxford John Kuriyan, Berkeley Michael James, Edmonton Jennifer Martin, Brisbane Kim Nasmyth, Oxford Herbie Newell, Newcastle Nikos Oikonomakos, Athens David Owen, Cambridge Richard Perham, Cambridge Gregory Petsko, Brandeis University, Waltham David Rice, Sheffield Mark Sansom, Oxford John Scott, Portland, Oregon David Stuart, Oxford Janet Thornton, Cambridge Soichi Wakatsuki, Photon Factory, Japan Matthias Wilmanns, EMBL, Hamburg Ian Wilson, San Diego Keith Wilson, York Stephen Withers, Vancouver Further information and on-line registration is available via: http://www.bioch.ox.ac.uk/lnjsymposium/Welcome.html Organising Committee Ravi Acharya David Barford Jane Endicott Janos Hajdu ___ David Barford Chester Beatty Laboratories Institute of Cancer Research 237 Fulham Road London, SW3 6JB United Kingdom Tel. +44 (0)20 7153 5420 FAX +44 (0)20 7153 5457 PA (Sonia Malkani) +44 (0)20 7153 5443 E. mail: [EMAIL PROTECTED] http://www.icr.ac.uk/research/research_sections/structural_biology/teams/barford_team/index.shtml The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
[ccp4bb] Team Leader in Structure-Based Drug Design
Team Leader in Structure-Based Drug Design Institute of Cancer Research, London The Institute of Cancer Research is seeking to appoint a Team Leader, who will spearhead the establishment and development of high-throughput approaches to structure-based drug design within The Institute of Cancer Research, and build a thriving research team developing and applying structure-based drug design techniques to therapeutic targets of relevance to the treatment of cancer. This new post will be a joint appointment between the Section of Structural Biology and the Cancer Research UK Centre for Cancer Therapeutics to establish in-house expertise in structure-based design. The successful applicant will have practical expertise in X-ray crystallography with a proven track record in structure determination and analysis of protein-ligand complexes, and a strong research interest in developing and applying high-throughput experimental and virtual ligand screening techniques. The Team Leader will be expected to interact closely with biologists and medicinal chemists throughout The Institute, and contribute to the development and management of emerging drug programmes. Further information is available on http://www.icr.ac.uk/jobs/(ref HAD135). For informal enquiries please contact either David Barford ([EMAIL PROTECTED]) or Laurence Pearl ([EMAIL PROTECTED]). ___ David Barford Institute of Cancer Research 237 Fulham Road London, SW3 6JB United Kingdom Tel. +44 (0)20 7153 5420 FAX +44 (0)20 7153 5457 E. mail: [EMAIL PROTECTED] http://www.icr.ac.uk/research/research_sections/structural_biology/teams/barford_team/index.shtml The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
