[ccp4bb] ESRF Users' Meeting 2013 Associated Structural Biology Workshop
Hello Everybody, The ESRF Users' Meeting, to be held in Grenoble from 4-6 February 2013, will focus on plans for Phase II of the ESRF Upgrade Programe. Current proposals include a major upgrade of the existing ESRF storage ring which will boost brilliance by a factor of 30 or more, providing access to flux densities in excess of 10^14 photon/s/micron^2 . In parallel with this year's Users' Meeting we are organising a workshop 'Seeing is believing: the future of Structural Biology'. The aims of the workshop are to present technical details of the proposed upgrade, to outline ideas for new scientific opportunities that will arise, to explore the limits of Structural Biology at a synchrotron source and to promote meaningful discussions between the ESRF and its User Community that will help formulate the scientific case for the future of Structural Biology at the ESRF. The program for the Workshop along with details of how to register for both the workshop and the Users' Meeting can be found at: http://www.esrf.fr/events/conferences/users-meeting-2013-and-workshops/workshop-seeing-is-believing-the-future-of-structural-biology I encourage as many of our current and future users to attend. With very best wishes for 2013. Yours Gordon
Re: [ccp4bb] Collecting small-molecule diffraction on a Macromolecular xtallography beam line
Hi Giorgo, Just to say that we routinely, and often, do these sorts of experiments on ID29 and ID23-1 at the ESRF using an energy of 20 keV (~0.62 Angstrom wavelength) and detector distances that allow collection of data to a resolution of better than 0.7A. Mini-kappa goniometers also allow for the collection of data in more than one crystal orientation in the case of completeness problems. As has already been pointed out by others who have replied to your posting, the processing of the images with MOSFLM or XDS is usually pretty straightforward as is structure solution using direct methods. Hope this helps Gordon At 12:41 08/02/2012, Giorgio Giardina wrote: Hello, I have some interesting small molecule xtals. I was wondering if it is possible to collect a small molecule data-set using a sincrotron macromolecular xtallography beam line, maybe with a very low beam intensity and moving the detector as close as possible? Has anybody experienced that? And if I get the images back home, can I process them using standard macromolecular software or do I need ab-initio special programs? Will MR work for phasing? Thanks in advance, Giorgio
[ccp4bb] 4th Winter School on soft X-rays in Macromolecular Crystallography
Hi Everyone, just a reminder about this. Yours Gordon 4th Winter School on soft X-rays in Macromolecular Crystallography We are pleased to announce that the 4th Winter school on soft X-rays in Macromolecular Crystallography will take place at the European Synchrotron Radiation Facility, Grenoble, France 6th 8th February 2012. An increasing number of new crystal structures of biological macromolecules structures are solved exploiting anomalous signals available at longer wavelengths. The main advantage of using longer wavelengths is that the anomalous signal from innate sulphur, phosphorous or other light atoms (e.g. Ca, K, Cl) can be used to obtain phasing information, thus obviating the need to prepare the derivative crystals usually used in macromolecular crystal structure solution. However, at longer wavelengths currently routinely accessible, such anomalous signals are rather small (usually ~ 1%). Special care must thus be given to experimental setups and data collection protocols. The Winter School brings together experts in the hardware and software required to successfully perform such experiments. The following topics will be covered: Optimised experimental setups for diffraction data collection at longer wavelengths Advanced data collection strategies, taking into account radiation damage Optimised protocols of data processing for longer wavelength experiments Anomalous scattering substructure determination using longer wavelength X-rays The Winter School will being held under the auspices of the ESRF Users Meeting and the number of participants limited to 20. Confirmed speakers at the workshop (see http://www.esrf.fr/events/conferences/users-meeting-2012-workshops/mx-school ) for provisional program) include: M. Cianci, EMBL Hamburg, Germany K. Djinovic-Carugo, Vienna Biocenter, Austria D. de Sanctis, ESRF, Grenoble, France P. Johansson, AstraZeneca Structural Chemistry Laboratory, Molndal, Sweden J. Liu, National Laboratory of Biomacromolecules, Beijing, China R. Giordano, ESRF, Grenoble, France G. Leonard, ESRF, Grenoble, France C. Mueller-Dieckmann, ESRF Grenoble J. Pflugrath, Rigaku, USA A. Popov, ESRF, Grenoble, France I. Uson, IBMB-CSIC, Barcelona, Spain A. Wagner, Diamond Light Source, UK B.C. Wang, University of Georgia, USA M. Wang, Swiss Light Source Villigen, Switzerland M.S. Weiss, Helmholtz-Zentrum für Materialien und Energie, Germany The Winter School registration fee of 150 includes all meals, 4 nights accommodation in the ESRF Guesthouse as well as registration for the ESRF Users' Meeting ( http://www.esrf.fr/events/conferences/users-meeting-2012-workshops/preliminary-programme ). Applications for participation in the Winter School should include a C.V., a letter of motivation, a poster abstract and (where appropriate) a recommendation letter from a PhD supervisor and be sent by Monday 12th December to the Winter School organisers at mx-winterschool2...@esrf.fr Further information concerning the workshop and application procedures can be found at http://www.esrf.fr/events/conferences/users-meeting-2012-workshops/mx-school On behalf of the organizers, Gordon Leonard
[ccp4bb] 4th Winter School on soft X-rays in Macromolecular Crystallography
4th Winter School on soft X-rays in Macromolecular Crystallography We are pleased to announce that the 4th Winter school on soft X-rays in Macromolecular Crystallography will take place at the European Synchrotron Radiation Facility, Grenoble, France 6th 8th February 2012. An increasing number of new crystal structures of biological macromolecules structures are solved exploiting anomalous signals available at longer wavelengths. The main advantage of using longer wavelengths is that the anomalous signal from innate sulphur, phosphorous or other light atoms (e.g. Ca, K, Cl) can be used to obtain phasing information, thus obviating the need to prepare the derivative crystals usually used in macromolecular crystal structure solution. However, at longer wavelengths currently routinely accessible, such anomalous signals are rather small (usually ~ 1%). Special care must thus be given to experimental setups and data collection protocols. The Winter School brings together experts in the hardware and software required to successfully perform such experiments. The following topics will be covered: Optimised experimental setups for diffraction data collection at longer wavelengths Advanced data collection strategies, taking into account radiation damage Optimised protocols of data processing for longer wavelength experiments Anomalous scattering substructure determination using longer wavelength X-rays The Winter School will being held under the auspices of the ESRF Users Meeting and the number of participants limited to 20. Confirmed speakers at the workshop (see http://www.esrf.fr/events/conferences/users-meeting-2012-workshops/mx-school ) for provisional program) include: M. Cianci, EMBL Hamburg, Germany K. Djinovic-Carugo, Vienna Biocenter, Austria D. de Sanctis, ESRF, Grenoble, France P. Johansson, AstraZeneca Structural Chemistry Laboratory, Molndal, Sweden J. Liu, National Laboratory of Biomacromolecules, Beijing, China R. Giordano, ESRF, Grenoble, France G. Leonard, ESRF, Grenoble, France C. Mueller-Dieckmann, ESRF Grenoble J. Pflugrath, Rigaku, USA A. Popov, ESRF, Grenoble, France I. Uson, IBMB-CSIC, Barcelona, Spain A. Wagner, Diamond Light Source, UK B.C. Wang, University of Georgia, USA M. Wang, Swiss Light Source Villigen, Switzerland M.S. Weiss, Helmholtz-Zentrum für Materialien und Energie, Germany The Winter School registration fee of 150 includes all meals, 4 nights accommodation in the ESRF Guesthouse as well as registration for the ESRF Users' Meeting ( http://www.esrf.fr/events/conferences/users-meeting-2012-workshops/preliminary-programme ). Applications for participation in the Winter School should include a C.V., a letter of motivation, a poster abstract and (where appropriate) a recommendation letter from a PhD supervisor and be sent by Monday 12th December to the Winter School organisers at mx-winterschool2...@esrf.fr Further information concerning the workshop and application procedures can be found at http://www.esrf.fr/events/conferences/users-meeting-2012-workshops/mx-school On behalf of the organizers, Gordon Leonard
[ccp4bb] Scientific Coordinator for the Partnership for Structural Biology, Grenoble
Apologies (once again) for the non-CCP4 nature of the advertisement below - Gordon The Partnership for Structural Biology (PSB) is an international consortium comprising the European Synchrotron Radiation Facility, the European Molecular Biology Laboratory, the Institut Laue Langevin, the Institut de Biologie Structurale and the University Joseph Fourier, in Grenoble, France (see http://psb.esrf.fr for more information). The goal of the PSB is to provide a comprehensive and integrated state-of-the-art environment to enable the study of challenging problems in structural biology, building on the complementary contributions of each of the Partner Institutes. To foster the development of the PSB we are now recruiting a Scientific Coordinator (m/f) for the Partnership for Structural Biology a 3-year contract THE FUNCTION: You will be a key figure in guiding the scientific programme of PSB. You will: · Coordinate, promote, stimulate and participate in the scientific activities of the PSB, · Act as point of contact for the PSB and ensure efficient implementation of policy decisions, · Coordinate grant applications and grant reporting by the PSB, · Assist in the organisation of the various PSB technical platforms and supervision of PSB core staff, · Prepare and monitor, together with the building manager and finance officer, the annual budget for the PSB, · Act as secretary to the different committees of the PSB. QUALIFICATIONS AND EXPERIENCE: You should hold a PhD in molecular, structural or cell biology and should have experience in scientific research. Experience and interest in administration and communication related to science is also required. Fluency in English is essential; fluency in French is a significant advantage. ADDITIONAL INFORMATION: You will work with all Partners to achieve the goals of the PSB, but will be employed by the ESRF. The ESRF offers an exciting opportunity in an international atmosphere. Installation allowances will be given to new staff coming from outside the Grenoble area, and an expatriation allowance can be given according to specific internal regulations. If you are interested, please send us a fax (+33 (0)4 76 88 24 60) or an e-mail ([EMAIL PROTECTED]) with your address, and we will provide you with an application form. You can also print out an application form on the World Wide Web http://www.esrf.fr/. Further information concerning the position available can be obtained from Prof. Sine Larsen ([EMAIL PROTECTED]) or Dr. Sean McSweeney ([EMAIL PROTECTED]). Ref. 2319 - Deadline for returning application forms: 15 December 2007 Applications received after the deadline may be considered for the selected vacancy if not filled or for future similar positions.
