[ccp4bb] PostDoctoral Position in Membrane Protein Structural Biology at USC, Los Angeles

[Cornelius Gati]

PostDoctoral Position in Membrane Protein Structural Biology at USC, Los Angeles

The position is available starting immediately in the Department of Biological 
Sciences at the University of Southern California and is initially limited to 2 
years, with possible extension.

Our research focuses on the structural biology of membrane proteins involved in 
synaptic transmission, using single particle cryoEM and X-ray crystallography, 
complemented by functional assays. We are working in close collaboration with 
the group of Prof. Vadim Cherezov (USC) on the structure determination of GPCRs.

USC has a suite of research facilities and has recently commissioned a 
brand-new cryoEM facility:
• CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, 
Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS 
and screening
• Core facility for insect- and mammalian cell expression
• High performance computing for data processing/analysis

Qualified candidates must have a Ph.D. degree with a solid background in 
structural biology and biophysics/biochemistry. Previous work with membrane 
proteins is a plus. A successful candidate is expected to be highly skilled and 
self-motivated and is willing to work in a collaborative environment. The 
Postdoctoral salary depends on qualifications and relevant experiences 
according to USC standards.

Interested candidates should apply directly with Cornelius Gati at 
gati[at]usc.edu. Please attach a cover letter, Curriculum 
Vitae, research statement, publication list and a reference letter. There is no 
deadline for this posting and applications will be evaluated on a rolling basis.

Current group website: https://dornsifecms.usc.edu/labs/gati-lab/


Recent work from our group includes:

H Shaye, A Ishchenko, JH Lam, GW Han, L Xue, P Rondard, JP Pin, V Katritch, C 
Gati*, V. Cherezov*
Structural basis of the activation of a metabotropic GABA receptor. Nature. 
2020.

S Rempel, C Gati*, M Nijland, C Thangaratnarajah, A Karyolaimos, JW de Gier, A 
Guskov*, DJ Slotboom*.
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds. 
Nature. 2020.



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[ccp4bb] PostDoctoral Position in Membrane Protein Structural Biology at USC, Los Angeles

[Cornelius Gati]

PostDoctoral Position in Membrane Protein Structural Biology at USC, Los Angeles

The position is available starting January 2021 in the Department of Biological 
Sciences at the University of Southern California and is initially limited to 2 
years, with possible extension.

Our research focuses on the structural biology of important membrane proteins, 
using single particle cryoEM and X-ray crystallography. We are working in close 
collaboration with the group of Prof. Vadim Cherezov (USC) on the structural 
biology of GPCRs. External collaborations include the group of Prof. Dirk 
Slotboom (Univ. of Groningen) and Prof. K. Chris Garcia (Stanford University).

USC has a suite of research facilities and is in the process of installing a 
new CryoEM center:

  *   Electron microscopy suite: Titan Krios with GIF Quantum energy filter and 
K3 detector, Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry 
holder for NS and screening
  *   Core facility for insect- and mammalian cell expression
  *   High performance computing for data processing/analysis

Qualified candidates must have a Ph.D. degree with a solid background in 
structural biology and biophysics/biochemistry. Previous work with membrane 
proteins is a plus. A successful candidate is expected to be highly skilled and 
self-motivated and is willing to work in a collaborative environment. The 
Postdoctoral salary depends on qualifications and relevant experiences 
according to USC standards.

Interested candidates should apply directly with Cornelius Gati at 
cornelius.gati[at]gmail.com. Please attach a 
cover letter, Curriculum Vitae, research statement, publication list and a 
reference letter. The deadline for the application is September 30th 2020.


Current group website: https://gati-lab.slac.stanford.edu/

Recent work from our group includes:

H Shaye, A Ishchenko, JH Lam, GW Han, L Xue, P Rondard, JP Pin, V Katritch, C 
Gati*, V. Cherezov*
Structural basis of the activation of a metabotropic GABA receptor. Nature. 
2020.

S Rempel, C Gati*, M Nijland, C Thangaratnarajah, A Karyolaimos, JW de Gier, A 
Guskov*, DJ Slotboom*.
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds. 
Nature. 2020.



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[ccp4bb] Postdoctoral position in membrane protein structural biology

[Seok-Yong Lee]

Dear colleagues,

Please pass this ad along any one who might be interested.  Seok-Yong


Applications are invited for a postdoctoral fellow position in the laboratory 
of Seok-Yong Lee at Duke University School of Medicine to work on the structure 
and mechanisms of ion channels and transporters. Please see our web page for 
more details on our research program: https://sites.duke.edu/leelab/ 

 
Candidates must have obtained a Ph.D. degree within the past three years and 
possess a strong background in protein biochemistry (protein expression and 
purification) and structural biology (single particle cryo-electron microscopy 
or X-ray crystallography) and be highly organized. Additional expertise in 
either membrane protein biochemistry or cryo-EM are plus. Strong verbal and 
written communication skills are highly desirable. 

 
The Lee lab is fully equipped for structural studies of membrane proteins and 
has frequent access to the 300 kV Titan Krios TEM with K3 and Falcon III 
detectors in the Duke University. 

 
If you are interested, please email your curriculum vitae, a cover letter 
describing your research experience and interests and contact information for 2 
references to seok-yong@duke.edu





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[ccp4bb] Postdoctoral Position on Membrane Protein Structural Biology at Karolinska Institutet, Sweden

[Madhuranayaki Thulasingam]

Dear bulletin board,


A postdoctoral position is available at the Department of Medical
Biochemistry and Biophysics (MBB), Division of Chemistry 2,  Karolinska
Institute, Stockholm. The project is focused on overexpression,
purification, and crystallization of human integral membrane enzymes
involved in the generation of lipid mediators of inflammation, all of which
are drug targets.


MBB is one of the largest departments at Karolinska Institutet equipped
with a range of state-of-the-art technologies in basic research, in
particular, structural biology, proteomics, imaging, and animal models. It
hosts world-leading groups in areas such as molecular neurobiology, matrix
biology, vascular biology, redox regulation, and lipid mediators of
inflammation, which together create a vibrant research environment.


A prospective candidate should hold a recently obtained PhD in structural
biology, biochemistry or a related area and a strong background in protein
chemistry, crystallization and structure determination by X-ray
crystallography and/or Cryo-EM, specifically membrane proteins. The
position is initially available for 2 years with a possibility of extension.



Interested candidates should send a letter of intention and CV including
references as a single PDF file by email to jesper.haeggst...@ki.se and

 madhuranayaki.thulasin...@ki.se. The position will remain open until
filled.


Best wishes,

Madhu.


Madhuranayaki Thulasingam, PhD
Division of Chemistry II
Department of Medical Biochemistry and Biophysics
Karolinska Institute
Biomedicum 9A
Solnavägen 17165, Solna
Stockholm, Sweden.



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[ccp4bb] Postdoctoral Position of Membrane Protein Structural Biology

[Hu, Jian]

Description:

A postdoctoral research associate position in membrane protein structural 
biology/biochemistry is immediately available in the Department of Biochemistry 
& Molecular Biology at Michigan State University, East Lansing, MI, US. One 
major direction in Dr. Jian Hu’s laboratory is structural biology study of 
metal transporters important in medicine. Previously, we have solved the first 
crystal structure of the extracellular domain of a mammalian ZIP4 zinc 
transporter (Nature Communications, 2016) and the first full length ZIP metal 
transporter (Science Advances, 2017). By employing multidisciplinary approaches 
of structural biology, biochemistry, biophysics and cell biology, we are aiming 
to establish the structural basis and clarify the molecular mechanisms of metal 
homeostasis in eukaryotic cells. The MSU cryo-EM facility will be updated with 
a new transmission and scanning transmission electron microscope by the end of 
2018. The laboratory is well funded by federal agencies, and the position can 
be supported up to four years based on mutual satisfaction. The other ongoing 
projects include biogenesis of the Ni-pincer cofactor, the PIPK lipid kinases 
and the calcium sensing receptor. To obtain more information, please visit our 
website (https://bmb.natsci.msu.edu/faculty/jian-hu/).

The successful candidate must be highly self-motivated with Ph.D. in structural 
biology, biochemistry, biophysics, molecular biology or related fields. 
Hands-on experience in membrane protein biochemistry is required. Experience in 
structural biology (x-ray crystallography/cryo-EM/NMR) is desirable, but not 
necessary. Interested individuals should submit a brief cover letter, CV, and 
the names and the contact information of three referees to Dr. Jian Hu by 
email: huji...@msu.edu.


~~

Jian Hu, PhD
Assistant Professor,
Department of Biochemistry and Molecular Biology &
Department of Chemistry,
Michigan State University,
603 Wilson Rd., East Lansing, MI 48824
https://bmb.natsci.msu.edu/faculty/jian-hu/



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[ccp4bb] Postdoctoral position in membrane protein structural biology at CSHL

[Furukawa, Hiro]

­

Postdoctoral position in membrane protein structural biology and 
electrophysiology

The laboratory of Hiro Furukawa at Cold Spring Harbor Laboratory (CSHL) is 
seeking an enthusiastic postdoc (NIH funded) with dynamic interests in solving 
questions in neuropharmacology using biochemical and biophysical techniques. We 
conduct structural biology (cryo-EM and x-ray crystallography) on transmembrane 
proteins to understand basic mechanisms of ion and substrate transport and on 
fragments of water soluble domains to answer specific pharmacological 
questions. We use diverse techniques to address protein functions including 
electrophysiology (two-electrode voltage clamp/patch-clamp/bilayer), imaging, 
calorimetry, and phage-display. We also attempt to understand critical 
protein-protein interactions in signal transduction cascades in neurons using a 
combination of proteomics, cryo-EM, and x-ray crystallography. CSHL will be 
equipped with Titan-Krios/K2 detector this summer. Importantly, it offers a 
unique scientific environment to interact with scientists within the institute 
as well as from outside at the prestigious CSHL courses and meetings (including 
the famous 2-week course, “X-ray Methods in Structural Biology” and the newly 
installed cryo-EM course). A desired candidate should hold or soon expected to 
hold (within ~0.5yr) Ph.D. in the area of cryo-EM, x-ray crystallography, or 
electrophysiology (biophysics). Please visit and see the lab website 
(http://furukawalab.labsites.cshl.edu/) before you apply and send CV with a 
brief research statement as well as 2-3 contacts for references to 
furuk...@cshl.edu.

Thank you.

[ccp4bb] Postdoctoral position in membrane protein structural biology

[Ieva Vasiliauskaite]

Labex Epigenmed Postdoctoral Scientist -Membrane Protein Structural Biology- 
Montpellier, France 



A two years post-doctoral position, funded by the Labex Epigenmed 
(https://www.epigenmed.fr/index.php/accueil/labex-overview), is available in 
the Granier lab at the “Institut de Génomique Fonctionnelle” (UMR 5203 CNRS, 
U1191 INSERM, Montpellier 
University,http://www.igf.cnrs.fr/granier/?page_id=57=en).

The position will be opened, from January 1st 2017, to study the structural 
pharmacology of a viral G-protein coupled receptor (vGPCR) involved in 
tumorigenesis. The work will involve protein biochemistry, biophysics and x-ray 
crystallography. The aim is to understand the vGPCR signal transduction 
mechanisms at the molecular level to enable the rational design of 
vGPCR-targeted antiviral drugs.

Candidates should have a strong background in protein biochemistry with the 
ability to characterize protein expression and purification from a large 
variety of systems. Candidates should also have a solid knowledge of structural 
biology methods (crystallography, electron microscopy, NMR or any combination 
thereof), as well as an excellent publication record for his/her career stage.

For more informations and to apply please contact Dr Sébastien GRANIER and Dr 
Cédric Leyrat

sebastien.gran...@igf.cnrs.fr ; cedric.ley...@igf.cnrs.fr

Interested candidates should forward a Curriculum Vitae (CV in english), and 
two or three letters of reference or e-mail contacts. 

[ccp4bb] Postdoctoral Position in Membrane Protein Structural Biology

[Noinaj, Nicholas (NIH/NIDDK) [E]]

Two postdoctoral positions in structural biology are available starting in 
August in my new laboratory within the Biological Sciences department at Purdue 
University. As part of the Markey Center for Structural Biology, my lab will 
integrate electron microscopy and X-ray crystallography with biochemical 
methods to study the biogenesis of beta-barrel membrane proteins in 
Gram-negative bacteria with a focus on eventual therapeutic development against 
pathogenic strains of bacteria (See Noinaj et al., Structure (in press, 2014), 
Nature, 501:385-390 (2013), and Nature, 483:53-58 (2012)).

The Markey Center for Structural Biology at Purdue is recognized worldwide for 
its leadership in structural biology of viruses, membrane proteins, receptors, 
signaling proteins and enzymes in addition to methods development in 
crystallography, NMR and electron microscopy. My lab is located within the 
Hockmeyer Hall of Structural Biology which boasts state-of-the-art shared 
resources including a Titan Krios cryo-TEM, Bruker Avance-III 800 MHz NMR, 
Rigaku X-ray generators and detectors, and other advanced instrumentation 
available at the Bindley Bioscience Center, the Birck Nanotechnology Center, 
and the new Center for Drug Discovery. In addition, Purdue is in close 
proximity to the Advanced Photon Source at Argonne National Lab for convenient 
access to synchrotron data collection.

The successful candidate(s) should be highly motivated, have strong written and 
communication skills, have (or expect) a recent PhD in structural biology, 
biophysics, biochemistry, or other related field of study and have previous 
experience in working with membrane proteins and/or X-ray crystallography or 
electron microscopy.

Applicants should send a CV, names of three referees and a statement describing 
your interests and relevant work experience to Nicholas Noinaj at 
nicholas.noi...@gmail.commailto:nicholas.noi...@gmail.com.



Nicholas Noinaj
Purdue University
Department of Biological Sciences
333 Hockmeyer Hall
915 W State St
West Lafayette, IN 47907

[ccp4bb] Postdoctoral position in membrane protein structural biology and pharmacology

[Hiro Furukawa]

---
Postdoctoral position in membrane protein structural biology and pharmacology
---

The laboratory of Hiro Furukawa at Cold Spring Harbor Laboratory (CSHL) is 
seeking an enthusiastic postdoc with dynamic interests in solving problems in 
neurological diseases and cancer using biochemical and biophysical techniques. 
We conduct x-ray crystallography on transmembrane proteins to understand basic 
mechanisms of ion and substrate transport and on fragments of water soluble 
domains to answer specific pharmacological questions. We use diverse techniques 
to address protein functions including electrophysiology, imaging, calorimetry, 
and phage-display. We also attempt to understand critical protein-protein 
interactions in signal transduction cascades in neurons and cancer cells using 
a combination of proteomics, electron microscopy, and x-ray crystallography. 
Other projects involve structure-based protein engineering of therapeutic 
antibodies. We have a state-of-the-art equipment to conduct membrane protein 
biochemistry and crystallography such as Mosquito LCP, frequent access to 
synchrotron light sources including NSLS and APS, and excellent facility for 
phage-display, proteomics, and microscopy. CSHL offers a unique scientific 
environment to interact with scientists within the institute as well as from 
outside at the prestigious CSHL courses and meetings (including the famous 
2-week course, “X-ray Methods in Structural Biology”). Highly interactive and 
educative nature of CSHL has traditionally created many successful independent 
scientists with unique and innovative visions. A qualified candidate should 
hold or soon expected to hold (within ~1yr) Ph.D. in the area of 
crystallography, electron microscopy, and biochemistry and have experiences in 
basic molecular biology, biochemistry, and protein expression. Experience in 
x-ray crystallography or electron microscopy is desired but not necessary. 
Please see the lab website (http://www.cshl.edu/public/SCIENCE/furukawa.html - 
will be updated soon) for further information and send CV with a brief research 
statement as well as 2-3 contacts for references to furuk...@cshl.edu. Thanks.

[ccp4bb] Postdoctoral Position on Membrane Protein Structural Biology

[Vadim Cherezov]

The Cherezov laboratory at The Scripps Research Institute 
(http://cherezov.scripps.edu) is looking for an exceptional and highly 
motivated candidate to work on the development of new technologies for membrane 
protein crystallization in lipidic environment as well as carry out 
crystallographic data collection and processing at synchrotron and 
free-electron laser sources. Prior experience with handling membrane proteins 
and demonstrated success are desired.
Please apply by sending a cover letter describing your intent and experience, a 
CV with a full list of publications, and 3 references to Vadim Cherezov 
(vcher...@scripps.edu).