[Freesurfer] Building a model

2022-02-09 Thread Marina Fernández
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Dear experts,

We run the following analysis in Freesurfer:

*Group* (2 levels) x *X1* (continuous IV) x *X2 *(continuous IV) +
*Sex *(categorical
covariate) + *Age* (continuous covariate)

We exported the vertex with the maximum statistic after applying FWE
correction to replicate the analysis in R. We want to make sure about the
structure of the model to later do a Bayesian analysis using the same
structure.

We got significant results for most of our analyses but not for all of
them, likely because we are not doing exactly the same thing.

We have fitted several models in R, but the one that gave the closest
results was the following:

model  <-  lm (vertex ~ NewFactor (4 levels: Group*Sex) + X1X2 (resulting
from X1*X2) * Group + Age*NewFactor, data=mydata)

How should we introduce the interaction term in order to make the models
fitted by Freesurfer and R comparable?

Thanks a lot in advance,

Marina
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Re: [Freesurfer] Building a model

2022-02-13 Thread Douglas N. Greve
Sorry, I don't understand the R terminology. in the FSGD, you will have 
(4+1)*3 = 15 columns to the design matrix (4=2x2=number of classes, 3 = 
no of continuous variables). Each column will mean something. How many 
columns will you have in your R analysis and what will they mean? If you 
can make R spit out a design matrix, you can just use that via the --X 
option to mri_glmfit.


On 2/9/2022 6:59 AM, Marina Fernández wrote:


External Email - Use Caution

Dear experts,

We run the following analysis in Freesurfer:

*Group* (2 levels) x *X1* (continuous IV) x *X2 *(continuous IV) + 
*Sex *(categorical covariate) + *Age* (continuous covariate)


We exported the vertex with the maximum statistic after applying FWE 
correction to replicate the analysis in R. We want to make sure about 
the structure of the model to later do a Bayesian analysis using the 
same structure.


We got significant results for most of our analyses but not for all of 
them, likely because we are not doing exactly the same thing.


We have fitted several models in R, but the one that gave the closest 
results was the following:


model  <-  lm (vertex ~ NewFactor (4 levels: Group*Sex) + X1X2 
(resulting from X1*X2) * Group + Age*NewFactor, data=mydata)


How should we introduce the interaction term in order to make the 
models fitted by Freesurfer and R comparable?


Thanks a lot in advance,

Marina


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Freesurfer@nmr.mgh.harvard.edu
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