Re: [Freesurfer] Designing Constrats for 3 Group 1 Covariate Analysis

[Douglas N. Greve]

Have you looked at this page?
https://surfer.nmr.mgh.harvard.edu/fswiki/FsgdExamples
You should be able to generalize the two groups, one covariate, to three 
groups


On 08/24/2018 01:06 PM, O'Dell, Ryan wrote:
>
> External Email - Use Caution
>
> Dear freesurfers,
>
>
> I have what is likely a basic question but I'm new not only to 
> FreeSurfer but contrast matrix design and group analysis as well, and 
> was hoping for some help/clarification.
>
>
> Basically I want to run a GLM on our structural/functional data in 
> order to determine if there's any significant correlation between 
> cortical thickness and cortical amyloid deposition (measured by PiB), 
> factoring in any potential effects of APOE genotype (e3e3, e3e4, 
> e4e4). This means I want to construct an FSGD file with a 3 groups 
> (the 3 APOE genotypes) and 1 covariate (our calculated cortical 
> composite PiB value) for this analysis. However, I'm struggling with 
> the proper contrast designs which test the various hypotheses in such 
> a setup.
>
>
> Any answers, thoughts, or insights would be greatly appreciated. I 
> know this type of analysis is also likely QDEC-able, but I think the 
> FSGD approach would be more beneficial for my understanding of 
> contrast matrix design. Please let me know if I've left out any 
> information that could potentially help clarify my question/request.
>
>
> Best,
>
>
> Ryan O'Dell MD/PhD
>
> PGY2 Psychiatry Resident, NRTP
>
> Yale University
>
>
>
>
> ___
> Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

___
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer


The information in this e-mail is intended only for the person to whom it is
addressed. If you believe this e-mail was sent to you in error and the e-mail
contains patient information, please contact the Partners Compliance HelpLine at
http://www.partners.org/complianceline . If the e-mail was sent to you in error
but does not contain patient information, please contact the sender and properly
dispose of the e-mail.

[Freesurfer] Designing Constrats for 3 Group 1 Covariate Analysis

[O'Dell, Ryan]

External Email - Use Caution

Dear freesurfers,


I have what is likely a basic question but I'm new not only to FreeSurfer but 
contrast matrix design and group analysis as well, and was hoping for some 
help/clarification.


Basically I want to run a GLM on our structural/functional data in order to 
determine if there's any significant correlation between cortical thickness and 
cortical amyloid deposition (measured by PiB), factoring in any potential 
effects of APOE genotype (e3e3, e3e4, e4e4). This means I want to construct an 
FSGD file with a 3 groups (the 3 APOE genotypes) and 1 covariate (our 
calculated cortical composite PiB value) for this analysis. However, I'm 
struggling with the proper contrast designs which test the various hypotheses 
in such a setup.


Any answers, thoughts, or insights would be greatly appreciated. I know this 
type of analysis is also likely QDEC-able, but I think the FSGD approach would 
be more beneficial for my understanding of contrast matrix design. Please let 
me know if I've left out any information that could potentially help clarify my 
question/request.


Best,


Ryan O'Dell MD/PhD

PGY2 Psychiatry Resident, NRTP

Yale University

___
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer


The information in this e-mail is intended only for the person to whom it is
addressed. If you believe this e-mail was sent to you in error and the e-mail
contains patient information, please contact the Partners Compliance HelpLine at
http://www.partners.org/complianceline . If the e-mail was sent to you in error
but does not contain patient information, please contact the sender and properly
dispose of the e-mail.