Re: [MBZ] COVID-19 Vaccines and study sizes

[Rick Knoble via Mercedes]

>People who know 1000x more than me on this subject say that mRNA is totally 
>safe and highly effective.


Okay.

https://youtu.be/ZJZxiNxYLpc

Rick
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Re: [MBZ] COVID-19 Vaccines and study sizes

[Mitch Haley via Mercedes]

On 2021-03-13 10:03, Tony Wirtel via Mercedes wrote:


I'll echo what was said before- if you can get a shot, take what you 
can

get.  The differences in efficacy are minor compared to the risk of
covid...esp w/the new variants swimming around.


I don't have a good personal track record with live viral culture vax, 
so JJ is a no-go for me.
People who know 1000x more than me on this subject say that mRNA is 
totally safe and highly effective.


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Re: [MBZ] COVID-19 Vaccines and study sizes

[Peter Frederick via Mercedes]

Another thing to consider is that ALL of them protect against severe disease.  
Feeling crappy for a few days vs intensive care and lung damage, etc, I'll take 
the feeling crappy.

Get whatever you can.  I suspect we will be getting boosters for this for a 
while, just like flu shots.
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Re: [MBZ] COVID-19 Vaccines and study sizes

[Tony Wirtel via Mercedes]

Long time without a post!

Given info from US FDA on size of phase 3 clinical trials the Pfizer study
is a close second to J&J.  Phase 3 is the last step to collect data before
one could apply for clearance to use in the US:

Pfizer: 43.651 (Combined phase 2/3)
https://www.fda.gov/media/144416/download (Table

Moderna: 30,418
https://www.fda.gov/media/144434/download  (Table 1)

J&J/Janssen: 44.325
https://www.fda.gov/media/146217/download   (Table 5)

While the Pfizer study was a combined phase 2/3 study (w/FDA blessing),
phase 2 studies are relatively small- for example, ~2k people in the
Moderna Phase 2.   If you have good data and are addressing an urgent need
you can ask FDA to combine a phase 2 and phase 3.  If they like your data,
they're likely to give you the green light.

While not common, this approach has been used with previous disease states
and drugs.

I'll echo what was said before- if you can get a shot, take what you can
get.  The differences in efficacy are minor compared to the risk of
covid...esp w/the new variants swimming around.

Tony Wirtel
...still Benzless


On Fri, Mar 12, 2021 Kaleb Striplin wrote

> To: Mercedes Discussion List 
> Subject: Re: [MBZ] OT - COVID Vaccine
> Message-ID: <17918ba0-945d-4369-80af-5e9f34b56...@striplin.net>
> Content-Type: text/plain; charset=utf-8
>
> I think that Pfizer one was tested on a very small sample which determined
> its effectiveness and the moderna was more fully tested, or so I was told.
>
> Sent from my iPhone
>
> > On Mar 12, 2021, at 7:18 AM, Dan Penoff via Mercedes <
> mercedes@okiebenz.com> wrote:
> >
> > ?I?ll take what they?re giving, as long as it works. A couple of
> percentage points either way isn?t going to make a difference.
> >
> > -D
> >
> >> On Mar 12, 2021, at 8:15 AM, Buggered Benzmail via Mercedes <
> mercedes@okiebenz.com> wrote:
> >>
> >> Either one is fine
> >>
> >> --FT
> >> Sent from iPhone
> >>
>
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