[NMusers] qPharmetra is hiring!
qPharmetra is hiring! Are you curious, motivated to share your knowledge with colleagues and clients, do you care about consistency and reproducibility in work product, and do you thrive when working in a collaborative environment? How about an exciting opportunity to join our group of enthusiastic pharmacometricians across the US and EU? At qPharmetra we are looking to expand our team with appropriate candidates! We are looking for skilled pharmacometricians as well as for a Data Programmer & PK Analyst for NCA. We prefer candidates with relevant educational background (Pharmaceutical Sciences, Medicine, Bioengineering, Statistics, etc.), and 5+ years' work experience, and having the skills to use our key tools (NONMEM, R, LaTeX, etc.). You might join our US offices in Boston Massachusetts or Research Triangle Park, North Carolina, or our European offices in Stockholm, Sweden and Nijmegen, the Netherlands. Alternatively, you might work from your home. Please get in touch and share with us your enthusiasm and motivation to join our ranks! Adding a resume will be highly appreciated. PS: No recruiters please. PS2: this is a resend of a previous email that had a problem in the signature and thus may have not have reached you (blocked) or been sent to you with an error message. Apologies for this. ____ Klaas Prins, PhD Vice President EU +31 618 802 292 (M) +31 248 457 290 (O) klaas.pr...@qpharmetra.com<mailto:klaas.pr...@qpharmetra.com> | www.qpharmetra.com<http://www.qpharmetra.com/>
[NMusers] qPharmetra is hiring!
qPharmetra is hiring! Are you curious, motivated to share your knowledge with colleagues and clients, do you care about consistency and reproducibility in work product, and do you thrive when working in a collaborative environment? How about an exciting opportunity to join our group of enthusiastic pharmacometricians across the US and EU? At qPharmetra we are looking to expand our team with appropriate candidates! We are looking for skilled pharmacometricians as well as for a Data Programmer & PK Analyst for NCA. We prefer candidates with relevant educational background (Pharmaceutical Sciences, Medicine, Bioengineering, Statistics, etc.), and 5+ years' work experience, and having the skills to use our key tools (NONMEM, R, LaTeX, etc.). You might join our US offices in Boston Massachusetts or Research Triangle Park, North Carolina, or our European offices in Stockholm, Sweden and Nijmegen, the Netherlands. Alternatively, you might work from your home. Please get in touch and share with us your enthusiasm and motivation to join our ranks! Adding a resume will be highly appreciated. PS: No recruiters please. ____ Klaas Prins, PhD Vice President EU qPharmetra, LLC +31 618 802 292 (M) +31 248 457 290 (O) klaas.pr...@qpharmetra.com<mailto:kevin.dyks...@qpharmetra.com> | www.qpharmetra.com<http://www.qpharmetra.com/>
RE: [NMusers] variation of time values in output data
If you subtract (DATE-1) * 24 from TIME in the output file it will match TIME in input file. NONMEM reads DATE as a DATE data item, that’s why. I suspect you won’t have this if you choose another column name for DATE (e.g. DAY). Note that this may also have an effect on the estimation process and thus your parameter estimates may change as well (for the better). Best regards, Klaas From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Diane-Charlotte Imbs Sent: Tuesday, April 21, 2015 11:47 AM To: Leonid Gibiansky Cc: nmusers@globomaxnm.com Subject: Re: [NMusers] variation of time values in output data Thank you, Leonid, for your answer but you can see (below) it’s not a rounding issue ; there are udge variations of time ?!!! INPUT FILE : ID DATE TIME DV AMT RATE MDV EVID 3 1 00 2000-2 1 1 3 1 2.6 1060 . . 0 0 3 1 170.117 331 . . 0 0 3 2 170.117 . 2000 -2 1 1 3 2 172.117 1220 . . 0 0 3 2 326.333 220 . . 0 0 3 3 326.55 . 2000-2 1 1 3 3 328.617 964 . . 0 0 3 3 504.833 1260 . . 0 0 OUTPUT FILE : ID DATE TIME IPREDCL D1 V1 IWRES 3 1 0 0 1.7711 113.17 35.2170 3 1 2.61223 1.7711 113.17 35.217 -0.13328 3 1 170.12 567.29 1.7711 113.17 35.217 -0.41653 3 2 194.12 169.68 1.7711 112.49 35.217 -1 3 2 196.12 1114 1.7711 112.49 35.217 0.09514 3 2 350.33 1110 1.7711 112.49 35.217 -0.80181 3 3 374.55 328.36 1.7711 140.63 35.217 -1 3 3 376.62 1089.8 1.7711 140.63 35.217 -0.11542 3 3 552.83 1208.1 1.7711 140.63 35.217 0.04297 Loïc FIEVET Interne IPR en pharmacocinétique Institut Universitaire du Cancer Toulouse - Oncopole 1 avenue Irène Joliot-Curie 31059 TOULOUSE Cedex 9 2015-04-20 19:21 GMT+02:00 Leonid Gibiansky lgibian...@quantpharm.commailto:lgibian...@quantpharm.com: it could be rounding issue when the precision of the TIME in the data file exceeds the precision of the TIME in the output of the table. You could increase precision of the output using format statement (see manual). Other than that, NONMEM should not change TIME variable. Leonid -- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web:www.quantpharm.comhttp://www.quantpharm.com e-mail: LGibiansky at quantpharm.comhttp://quantpharm.com tel:(301) 767 5566 On 4/20/2015 12:12 PM, Diane-Charlotte Imbs wrote: Dear nonmem users, We used the option “-2 RATE” of NONMEM (actual rate of infusion is unknown): within the control stream: D1=THETA(1) Moreover, since several infusions are given to the same patients, we have added an inter-occasion variability on D1 (see code below)* We obtained nice fit BUT in the OUTPUT DATA: TIME values corresponding to blood samples (and DV) are not identical to the actual TIME values of the INPUT data !? It seems that NONMEM program adjusts rate values, their interoccasion variability, and sampling times to have a good fit *How to fix TIME value corresponding to blood samples ? Indeed, we do not know the actual infusion rate but we do know the sampling times.* ** Can anyone tell me if I chose the right model or help me resolving this? Thanks in advance, *$PK OCC1=0 OCC2=0 IF(DATE.EQ.1) OCC1=1 IF(DATE.EQ.2) OCC2=1 D1=THETA(1)*EXP(ETA(3)+ETA(4)*OCC1+ETA(5)*OCC2) $THETA (0,168,);D1 $OMEGA .1 ; iiv d1 $OMEGA BLOCK(1) .01 ; iov ETA4 OCC1 $OMEGA BLOCK(1) SAME ; iov ETA5 OCC2 *Loïc FIEVET* */Interne IPR en pharmacocinétique (1^er semestre)/* *Institut Universitaire du Cancer Toulouse - Oncopole* 1 avenue Irène Joliot-Curie 31059 TOULOUSE Cedex 9
Re: [NMusers] Question about interoccation variability
I think I would try IOV on F1 first before putting it on KA like Jean suggested but above all I think there is an essential element missing in your code. IOV is variability between occasions on top of inter individual variability. So do something like: F1=1 F1=THETA(1)*EXP(ETA(6)+BOVKA) $OMEGA 0.25 ; IIV F1 Furthermore, there may be other elements contributing to the inability to predict Cmax well, such as more complex absorption features. I think we lack info to comment on that. HTH, Klaas On 10 jul. 2012, at 23:56, Lavigne, Jean jean.lavi...@celerion.com wrote: KA=THETA(1)*EXP(BOVKA)
