I think I would try IOV on F1 first before putting it on KA like Jean suggested but above all I think there is an essential element missing in your code. IOV is variability between occasions on top of inter individual variability.
So do something like: F1=1 F1=THETA(1)*EXP(ETA(6)+BOVKA) $OMEGA 0.25 ; IIV F1 Furthermore, there may be other elements contributing to the inability to predict Cmax well, such as more complex absorption features. I think we lack info to comment on that. HTH, Klaas On 10 jul. 2012, at 23:56, "Lavigne, Jean" <jean.lavi...@celerion.com> wrote: > KA=THETA(1)*EXP(BOVKA)
