PhD Position in structure-based drug design in diabetes at the Institute of
Structural Biology, Helmholtz Zentrum München, Munich (Germany)
Job Details
The need for new and more effective drugs for type 2 diabetes is a major health
concern. The main objective of this project is to discover new
If you show symmetry mates I'm sure the ones Coot found outside your protein
are actually in the sites you are missing.
Nothing to worry, just safe the symmetry mate and read in those coordinates
merge with your current model.
Jürgen
..
Jürgen Bosch
Johns Hopkins University
The Protein Structure Section of the Macromolecular Crystallography Laboratory,
National Cancer Institute, Frederick, Maryland, USA has an immediate opening
for a postdoctoral fellow to join an ongoing research project involving studies
of cytokines, cytokine receptors, and associated kinases.
Dear Giovanna and Bosch:
Thank you for your advices.
I tried the way as you suggested, but not work.
Here is how I did:
1. Center on the ligand density, and Find ligand Right here.
2. Increase Fo-Fc at 3 sigma or reduce 2Fo-Fc maps to 0.8 sigma.
Coot failed to recognize the density.
You do
That's not what I suggested.
you have a tetramer and you have found two ligands within the protein and two
ligands outside your protein - right ?
Now if you merge those 4 found ligands with your protein and then turn on
symmetry mates you will find that the two ligands which were shown outside
Exciting research opportunities in the ion channel structure and mechanism area
are available for two highly motivated post-doctoral fellows at the Weill
Cornell Medical College in New York City, Department of Anesthesiology. The
research focuses on analyzing ion channel function with
Hello everybody,
I'm looking for small proteins (up to 150 aa) that are known to express
reasonably in E. coli, are soluble and folded but failed to crystallize.
Can you provide some examples, especially of proteins that might be
interesting for a broad community?
Thanks,
Karolina
Dear members,
I have one difficult task on hand and would like to ask for your advice.
I want to superpose two enzyme structures just based on several residues
(e.g. 5 residues) which we are interested in. But these two structures do
not have similarity for overall structures. In this case, I
Hi Wenhe,
Superpose allows you to specify residue (as well as Ca/main chain/side chain)
ranges. Also in COOT you can select the range of residues used in the LSQ
superpose calculation.
For superposing parts of the proteins only, a little trick is to cut the
interested fragments from the
Ccp4's Gesamt (new algorithm, interfaced jointly with SSM in ccp4i) should do
what you want -- Eugene
From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] on behalf of Zhijie Li
[zhijie...@utoronto.ca]
Sent: Thursday, October 25, 2012 12:45 AM
To: ccp4bb
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