Dear Jacob,
Citrate synthase is another early (historically) case, and GAPDH (on binding
NAD).
Andrew
On 27 Feb 2014, at 19:43, Keller, Jacob kell...@janelia.hhmi.org wrote:
Dear Crystallographers,
Does anyone know of good examples of large, reversible conformational changes
occurring
Dear Jacob,
We recently solved crystal structures of apo and ligand bound forms of a
cofactor S-adenosyl-methionine (SAM) dependent methyltransferase RlmJ
(http://nar.oxfordjournals.org/content/41/20/9537.long). Comparison of the
structures revealed that binding of the cofactor and a substrate
I think it may well be a problem with the scaling.
It is hard to get a reasonable estimate of the Wilson B at 3A -
especially in a small cell.
Look at the Log Graph plots - one associated with R factor gives you
Fobs and Fcalc v resolution. They SHOULD overlap pretty well, but
sometimes they dont
Abbas Ourmazd who is physics professor at Milwaukee has asked me to post
this job advert on CCP4bb:
http://jobs.sciencecareers.org/job/325225/assistant-or-associate-professor-in-biophysics/
George
--
Prof. George M. Sheldrick FRS
Dept. Structural Chemistry,
University of Goettingen,
Dear CCP4 Users,
An update for the CCP4-6.4.0 series has just been released, consisting
of the following changes:
* areaimol
- Fix to atom records of output pdb.
* mrbump
- Several fixes including bug fixes to allow SHELXE to run when
submitting jobs to a cluster.
* theseus
-
A Postdoctoral Scholar position in structural biology is available in the
laboratory of Dr. Oleg Tsodikov at the Department of Pharmaceutical
Sciences at the University of Kentucky (
Jacob,
Many enzymes do this, not quite as dramatic as calmodulin, but especially
hexokinase, and this is important because it was the origin of Koshland's
induced fit idea. Glycogen phosphorylase, aspartate transcarbamylase, and
phosphofructokinase also do radical things involving subunit
Dear CCP4 community -
In case anyone missed this, one interesting example of large conformational
changes associated with ligand binding event(s) is T7 RNA polymerase,
involved in the initiation, elongation and termination of mRNA synthesis
following promoter recognition.
Tom Steitz' review from
Scientist or Research Assistant Professor
A scientist or research assistant professor position (depending on experience
and qualifications) is available to develop intelligent software for advanced
protein crystallography experiments at the Shanghai synchrotron in
collaboration with
The Eighth International Workshop on X-ray Radiation Damage to Biological
Crystalline Samples will be held at the EMBL and DESY, Hamburg, Germany from
April 10th (13:00) to April 12th (13:00) 2014.
The full programme for this Workshop can now be found at:
10 matches
Mail list logo
