Re: [ccp4bb] About the A in AI

2023-05-12 Thread DUMAS Philippe (IGBMC)
Bayesian reasoning: Given the observation of the complete identity of the 2 reports, what is the likelyhood that Bing & ChatGPT arrived at the same result vs. the null hypothesis that Bernhard made a simple "cut & paste" mistake. Philippe Dumas De: "Bruno KLAHOLZ" À: "CCP4BB" Envoyé: V

Re: [ccp4bb] Can twinning be seen in the diffraction pattern?

2021-03-17 Thread DUMAS Philippe (IGBMC)
It seems to me that it is legitimate to refer to what you describe as "twinning". That's the difference between merohedral and non-merohedral twinning. What you describe is non-merohedral twinning. In fact twinning has been (re)discovered by most of the biological community after the remarkable

Re: [ccp4bb] Regarding difference in ITC and structure data

2020-08-01 Thread DUMAS Philippe (IGBMC)
Monika Did you try ITC experiments at different temperatures ? Delta H may be null, or close to zero, at some temperature without implying that there is no binding ! Philippe Dumas De: "monika chandravanshi" À: "CCP4BB" Envoyé: Samedi 1 Août 2020 09:57:24 Objet: [ccp4bb] Regarding diffe

Re: [ccp4bb] disinfecting keyboards

2020-04-29 Thread DUMAS Philippe (IGBMC)
I got a good advice about it: inject WhiteHouse disinfectant right into the cpu. Good to repeat it a couple of times, but wear mask and gloves against possible Cotrump-16-20 last attacks ! Hope it will be helpful. Philippe Dumas (#SupportFauci) - Mail original - De: "Jurgen Bosch" À:

Re: [ccp4bb] CCP4BB vs COVID19

2020-03-22 Thread DUMAS Philippe (IGBMC)
Relevant to the discussion: * Cell, Vol. 110, 551–561, September 6, 2002, Copyright 2002 by Cell Press An RNA Thermosensor Controls Expression of Virulence Genes in Listeria monocytogenes * Bacterial RNA thermometers: molecular zippers and switches Jens Kortmann and Franz Narberhaus NATURE

Re: [ccp4bb] ITC Stoichiometry

2020-02-21 Thread DUMAS Philippe (IGBMC)
Dear Angshu The answer to your question requires to define precisely the term of "stoichiometry". *If you consider the hexamer as "the molecule B", then the expected stoichiometric ratio is 1/1 (one molecule A should bind to 1 hexamer B). *But if you consider the monomer of B as "the molecule"

Re: [ccp4bb] ITC question -dimer vs monomer

2019-10-03 Thread DUMAS Philippe (IGBMC)
Dear Bernhard I share your intuition: we should expect to observe different shapes of titration curves depending on whether A or B2 is in the syringe (titration and reverse titration). I suppose that you want to test your hypothesis that, eventually, you get A2B2. Independently of any kinetic