Dear all,
Does anyone happen to know examples of 2 ligands bind to a single protein /
each monomer protein in 2 different ligand binding pockets?
I know the following example:
(1). phosphofructokinase, which binds ATP as both a ligand and a feedback
inhibitor in different sites
(2). 2 cAMP bound t
Dear Wei,
The enzyme ribonucleotide reductase can, depending on organism and class, bind
ATP as a substrate in the active site (c), as an allosteric regulator of
substrate specificity at another site (s) and as an overall activity regulator
at a third site (a)! It can also bind dATP at the seco
Hi,
Another example is the Shiga-like toxin B-subunit pentamer (i.e. the
cell-surface binding component of this A-B toxin), which binds 3 Gb3
trisaccharides per monomer:
http://pdbe.org/1bos
http://www.ncbi.nlm.nih.gov/pubmed/9485303
Best wishes,
Randy Read
On 4 Mar 2014, at 10:41, Derek Log
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Dear Wei,
if you are not restricted to 2 ligands, you can also look at human
serum albumin, http://pdb.org/pdb/101/motm.do?momID=37
Best regards,
Tim
On 03/04/2014 04:48 AM, Wei Shi wrote:
> Dear all, Does anyone happen to know examples of 2 ligands
Thank you all so much!
Best,
Wei
On Tue, Mar 4, 2014 at 7:51 AM, Tim Gruene wrote:
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> Dear Wei,
>
> if you are not restricted to 2 ligands, you can also look at human
> serum albumin, http://pdb.org/pdb/101/motm.do?momID=37
>
> Best regards,
>
