This can be done automatically using either SADAPT or PDX-MC-PEM.
Both programs will give you also at the end an output summary (bias,
imprecision, etc...)
Serge
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Leonid Gibiansky
Sent:
Do you bootstrap the individual patients X times and then fit the model
to these new datasets or do you simulate datasets based on the final
population characteristics you already established? Both options are
also automated in the PDX-MC-PEM program and I think also in SADAPT.
Best
Serge
___
When you perform a population analysis, the program returns the
population means as well as the individual parameter estimates (mode of
the individual conditional distributions). If you plug the population
means values into your model and for each patient, you will get back the
population predicted
Greetings! I am looking for a clarification/explaination of the difference
between population-predicted values (say for concentration) and
individual-predicted values. Thank you to anyone who can provide this!
Susan Hudachek, M.S., Ph.D.
Animal Cancer Center
Veterinary Teaching Hospital
Colorado
Hi Robm
the simulatio step runs fine as I checked by using SIMONLY
the termination says
"0PROGRAM TERMINATED BY OBJ
ERROR IN NCONTR WITH INDIVIDUAL 16 ID=0.1600E+02
NUMERICAL HESSIAN OF OBJ. FUNC. FOR COMPUTING CONDITIONAL ESTIMATE
IS NON POSITIVE DEFINITE
MESSAGE ISSUED FROM ESTIMATION ST
The "distribution lag" is not a function of ICON Development Solutions.
It is a function of several issues, the foremost of which are net
traffic and timing and corporate/net provider processing. Messages sent
before 8am US Eastern time can be distributed relatively quickly. Those
sent in the mid
Dear Martin and Elodie and others,
Thanks for pointing out this nice function of PsN-- I think I will give it a
try this time.
From: Martin Bergstrand
To: Sebastian Ueckert ; Ethan Wu
Cc: nmusers@globomaxnm.com
Sent: Friday, February 6, 2009 5:52:09
This is not from nmusers. One of the list recipients (or the company
hosting his or her mail) is treating nmusers messages as spam.
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Ethan Wu
Sent: Thursday, February 05, 2009 7:
Hi Ethan,
If think you get the message "message issued from estimation step" you still
have the $ESTIMATION block in your control stream, although you're using
SIMONLY option. Try removing the $ESTIMATION block and try again. Perhaps you
could post your control stream as well?
Sincerely,
Rob
Yes, it is fixed in Nonmem VII.
Katya
--
Ekaterina Gibiansky
Senior Director, PKPD, Modeling & Simulation
ICON Development Solutions
ekaterina.gibian...@iconplc.com
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Be
Dear all,
My apologies for sending redundant messages. The reason this often
happens is a distribution lag of about half an hour* (at least for me).
By the time the message reaches other nmusers it is already obsolete
because someone else answered before. Is there any way that Globomax can
incr
Hi,
I dont understand why this wasn't fixed in NONMEM VI. It was a well
known bug in NONMEM V and has caused lots of grief for users.
I hope the NONMEM VII developers have got this high on their list of
NONMEM bugs that need to be fixed.
Nick
Dear users,
I am trying to compare several s
Ethan,
As Leonid suggests, you may want to control NONMEM runs using an
external tool and an INFN routine for extraction of results. MIfuns,
an open-source R package, provides functions for this sort of
automation. Template INFN codes are provided as well. It's a free
download:
http://met
Dear all,
PsN is useful tool for this purpose but I think that the functionality that
should be used is called "Stochastic Simulation and Estimation (SSE)". The
Bootstrap functionality is primarily used for obtaining parameter
uncertainties. A detailed userguide for the SSE functionality is
Dear Ethan,
Have you tried removing the $ESTIMATION step and replace all values with your
final estimations? What does your result file say after termination?
Sincerely
Rob
>>> Sebastian Ueckert 02/06/09 10:51 >>>
On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu wrote:
> Dear users,
> I am t
Ethan,
Sebastian is right that a non-parametric bootstrap may be suitable for
determining the uncertainty in the population parameters. However, I got
the impression that you wanted to investigate possible study designs on
how informative they are for a future model-based analysis? If you would
Dear Ethan,
Perl-speaks-NONMEM (PsN) is a free program developed by Uppsala Research
Pharmacometrics group. We recently added a module performing Stochastic
Simulations followed by re-Estimations (SSE). The purpose is to investigate
aspects related to simulation or estimation methods, models, s
Dear Ethan,
the simplest solution to solve your problem would be to use the bootstrap
command of PSN (http://psn.sourceforge.net/). With PSN installed you would
simply do:
bootstrap final_model.mod -samples=200
PSN would take care of unsuccessful runs and provide a nice summary of the
individual
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