[NMusers] Why are my posts not appearing on nmusers?

I sent two posts to nmusers this morning (NZ time). The first never showed up but the second one did. I tried sending the first post two more times and they did not appear on nmusers. This is a test post to see if all my posts are being blocked. -- Nick Holford, Professor Clinical Pharmacology

Re: [NMusers] OMEGA matrix

Dear Pavel, With regard how to handle this differently in Monolix, you probably better ask their developers (or perhaps Marc is listening in...). It would not surprise me if it would because of statistical reasons rather than practical ones. On the subject of shrinkage: the sampling I was talki

Re: [NMusers] OMEGA matrix

Hi, As pointed out by others I agree it is essential to consider the existence of random effect correlations if you wish to make model predictions e.g. to use a VPC to evaluate a model. I agree with Jeroen that this should be primarily be an informed choice based on physiology/pharmacology.

RE: [NMusers] OMEGA matrix

Hi Jeroen, I think we might be on the same page but I wanted to get clarification about your suggestion that we “not apply the concept of over-parameterization” with respect to evaluating the omega structure. I’m assuming by ‘over-parameterization’ you mean a model that has more elements in

Re: [NMusers] OMEGA matrix

Sorry Jeroen, I have to correct you name in the email:   Dear Jeroen and the NONMEM Team,   Your email is definitely informative.    1. "Off-diagonal elements (as explained by Bob Bauer) are available as sample correlations and do not have to be separately computed in contrast to

Re: [NMusers] OMEGA matrix

Dear Joren and the NONMEM Team,   Your email is definitely informative.    1. "Off-diagonal elements (as explained by Bob Bauer) are available as sample correlations and do not have to be separately computed in contrast to linearization approaches such as FOCE."  It may explain the

[NMusers] Register of ACoP5, October 12 - 15, Las Vegas, Nevada

Registration fees are increasing on October 1st - Register Now! We're less than a month away from the much anticipated ACoP5 meeting. Space is limited and filling up fast with less than 50 spaces available. Take a few moments to secure your spot at this scientific event for professionals dedicated

[NMusers] Intro to Phoenix WinNonlin Training in Sunnyvale, CA

Register today! 20% early registration discount (Expires October 1, 2014) 30% off of groups 50% off for students Introduction to Phoenix WinNonlin December 2-4, 2014 Sunnyvale, CA This class provides new and current WinNonlin users the experience to use