Hi Patricia,
If the stopping of pump is an artifact and you are interested in getting
parent-metabolite parameters without bias, I would approach in a progressive
manner:
1. I would model parent IV data alone with an eta on Duration and then fix
duration parameter with EBE (for doses that have t
Dear Patricia,
Your infusion time will not be semantically distributed.
I suppose maximum distribution toward planned DUR. But you may have left
half of the distribution curve with maximum value of predetermined infusion
time.
So model is likely to be
D1* (1-abs(THETA(1)*EPA(1)))
On Wed, Au
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